Published in Genes Cancer on March 01, 2012
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Rearrangement of mitochondrial pyruvate dehydrogenase subunit dihydrolipoamide dehydrogenase protein-protein interactions by the MDM2 ligand nutlin-3. Proteomics (2016) 0.75
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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science (2004) 24.42
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P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol (2008) 2.43
Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell (2007) 2.42
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An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell (2010) 1.91
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Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell (2009) 1.60
The conformationally flexible S9-S10 linker region in the core domain of p53 contains a novel MDM2 binding site whose mutation increases ubiquitination of p53 in vivo. J Biol Chem (2002) 1.50
The identification of an internal ribosomal entry site in the 5'-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. Oncogene (2006) 1.41
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The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell (2012) 1.30
Expression of p53 and p53/47 are controlled by alternative mechanisms of messenger RNA translation initiation. Oncogene (2006) 1.18
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin. Dev Biol (2011) 1.13
Applications of bioluminescence- and fluorescence resonance energy transfer to drug discovery at G protein-coupled receptors. Eur J Pharm Sci (2004) 1.11
P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2. FEBS Lett (2002) 1.10
Human proteome-scale structural modeling of E2-E3 interactions exploiting interface motifs. J Proteome Res (2012) 1.05
Drug discovery and mutant p53. Trends Cell Biol (2010) 1.04
MDM2 chaperones the p53 tumor suppressor. J Biol Chem (2007) 1.04
A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. J Biol Chem (2009) 1.01
Structural and functional comparison of the RING domains of two p53 E3 ligases, Mdm2 and Pirh2. J Biol Chem (2010) 1.00
Nucleolar localization and mobility analysis of the NF-kappaB repressing factor NRF. J Cell Sci (2004) 0.95
Regulation of the E3 ubiquitin ligase activity of MDM2 by an N-terminal pseudo-substrate motif. J Chem Biol (2009) 0.90
Turning the RING domain protein MdmX into an active ubiquitin-protein ligase. J Biol Chem (2010) 0.86
Expansion of protein interaction maps by phage peptide display using MDM2 as a prototypical conformationally flexible target protein. J Mol Biol (2004) 0.86
ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1. FEBS J (2008) 0.85
Nanosensing protein allostery using a bivalent mouse double minute two (MDM2) assay. Proc Natl Acad Sci U S A (2012) 0.80
First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors. Biotechnol J (2011) 0.79
Using BRET to study chemical compound-induced disruptions of the p53-HDM2 interactions in live cells. Biotechnol J (2010) 0.79
p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol (2002) 2.93
Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1. Science (2003) 2.46
P53 mRNA controls p53 activity by managing Mdm2 functions. Nat Cell Biol (2008) 2.43
Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation. Proc Natl Acad Sci U S A (2011) 1.40
The p53 mRNA-Mdm2 interaction controls Mdm2 nuclear trafficking and is required for p53 activation following DNA damage. Cancer Cell (2012) 1.30
Endoplasmic reticulum stress induces G2 cell-cycle arrest via mRNA translation of the p53 isoform p53/47. Mol Cell (2010) 1.26
M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation. Proc Natl Acad Sci U S A (2013) 1.10
Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway. Proc Natl Acad Sci U S A (2013) 1.08
Gly-Ala repeats induce position- and substrate-specific regulation of 26 S proteasome-dependent partial processing. J Biol Chem (2008) 1.08
Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. J Biol Chem (2008) 1.06
MDM2 chaperones the p53 tumor suppressor. J Biol Chem (2007) 1.04
beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53. Proc Natl Acad Sci U S A (2007) 1.03
Allosteric effects mediate CHK2 phosphorylation of the p53 transactivation domain. EMBO Rep (2003) 1.01
Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. J Mol Biol (2004) 1.00
mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1. J Virol (2008) 1.00
Stress-dependent changes in the properties of p53 complexes by the alternative translation product p53/47. Cell Cycle (2008) 0.97
The p53 mRNA-Mdm2 interaction. Cell Cycle (2009) 0.97
Data-independent proteomic screen identifies novel tamoxifen agonist that mediates drug resistance. J Proteome Res (2011) 0.97
Epstein Barr virus-encoded EBNA1 interference with MHC class I antigen presentation reveals a close correlation between mRNA translation initiation and antigen presentation. PLoS Pathog (2010) 0.91
Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway. Biochem J (2013) 0.87
An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis. J Proteome Res (2012) 0.87
The role of mRNA translation in direct MHC class I antigen presentation. Curr Opin Immunol (2012) 0.86
Identification of a dominant negative functional domain on DAPK-1 that degrades DAPK-1 protein and stimulates TNFR-1-mediated apoptosis. J Biol Chem (2007) 0.86
Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation. J Am Soc Mass Spectrom (2011) 0.84
Adaptive evolution of a stress response protein. PLoS One (2007) 0.84
Searching for the Holy Grail; protein-protein interaction analysis and modulation. EMBO Rep (2012) 0.83
Technology insight: the application of proteomics in gastrointestinal disease. Nat Clin Pract Gastroenterol Hepatol (2007) 0.81
Tuberous sclerosis-2 (TSC2) regulates the stability of death-associated protein kinase-1 (DAPK) through a lysosome-dependent degradation pathway. FEBS J (2010) 0.81
Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4. Anal Chem (2008) 0.81
The novel platinum(IV) complex LA-12 induces p53 and p53/47 responses that differ from the related drug, cisplatin. Anticancer Drugs (2008) 0.80
Epstein-Barr virus-encoded EBNA1 and ZEBRA: targets for therapeutic strategies against EBV-carrying cancers. J Pathol (2015) 0.79
A germ line mutation in the death domain of DAPK-1 inactivates ERK-induced apoptosis. J Biol Chem (2007) 0.79
A novel ataxia-telangiectasia mutated autoregulatory feedback mechanism in murine embryonic stem cells. J R Soc Interface (2009) 0.79
Using BRET to study chemical compound-induced disruptions of the p53-HDM2 interactions in live cells. Biotechnol J (2010) 0.79
The alternative translated MDMX(p60) isoform regulates MDM2 activity. Cell Cycle (2015) 0.79
An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing. FEBS J (2008) 0.78
Inhibition of p53-dependent, but not p53-independent, cell death by U19 protein from human herpesvirus 6B. PLoS One (2013) 0.78
Human herpesvirus-6B protein U19 contains a p53 BOX I homology motif for HDM2 binding and p53 stabilization. Virology (2013) 0.78
A yeast-based assay identifies drugs that interfere with immune evasion of the Epstein-Barr virus. Dis Model Mech (2014) 0.77
[Self-inhibition of EBNA1 protein to escape from immune recognition]. Med Sci (Paris) (2004) 0.75
Chek2ing out the p53 pathway: can Puma lead the way? Cell Cycle (2011) 0.75
RNA-assisted protein folding. Biotechnol J (2008) 0.75
An animal model to evaluate the function and regulation of the adaptively evolving stress protein SEP53 in oesophageal bile damage responses. Cell Stress Chaperones (2008) 0.75