Published in Cell Physiol Biochem on November 18, 2016
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Prevalence and control of diabetes in Chinese adults. JAMA (2013) 11.73
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol (2006) 6.45
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell (2006) 5.10
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Dev Cell (2008) 4.26
Safety and immunogenicity of an inactivated adjuvanted whole-virion influenza A (H5N1) vaccine: a phase I randomised controlled trial. Lancet (2006) 4.22
Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol (2013) 4.04
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
The way forward. Lancet (2007) 3.28
Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest (2013) 3.25
Immunohistochemical localization of programmed death-1 ligand-1 (PD-L1) in gastric carcinoma and its clinical significance. Acta Histochem (2006) 3.24
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc Natl Acad Sci U S A (2012) 3.22
Nanospring behaviour of ankyrin repeats. Nature (2006) 3.02
Health effects of the 2003 Southern California wildfires on children. Am J Respir Crit Care Med (2006) 2.81
C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell (2010) 2.68
AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. Cell (2005) 2.68
Abandon the mouse research ship? Not just yet! Shock (2014) 2.60
CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. Cancer Res (2012) 2.50
Readers of histone modifications. Cell Res (2011) 2.40
Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs. Nat Biotechnol (2009) 2.36
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res (2011) 2.36
A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35
Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer (2008) 2.35
Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep (2013) 2.10
TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell (2012) 2.03
Myotube assembly on nanofibrous and micropatterned polymers. Nano Lett (2006) 2.00
Ultrasound-targeted gene delivery induces angiogenesis after a myocardial infarction in mice. JACC Cardiovasc Imaging (2009) 1.94
Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. J Biol Chem (2008) 1.89
EBF2 determines and maintains brown adipocyte identity. Cell Metab (2013) 1.85
Surgical management of thymic epithelial tumors: a retrospective review of 204 cases. Ann Thorac Surg (2005) 1.82
Cerebral oxygen saturation-time threshold for hypoxic-ischemic injury in piglets. Anesth Analg (2009) 1.82
Efficient feeder-free episomal reprogramming with small molecules. PLoS One (2011) 1.79
St John's wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther (2004) 1.79
Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metab (2013) 1.76
The multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily. Eur J Biochem (2003) 1.76
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood (2011) 1.74
Cryopreservation of complex systems: the missing link in the regenerative medicine supply chain. Rejuvenation Res (2006) 1.73
Enamel microstructure--a truly three-dimensional structure. J Hum Evol (2003) 1.73
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
Efficient and accurate bypass of N2-(1-carboxyethyl)-2'-deoxyguanosine by DinB DNA polymerase in vitro and in vivo. Proc Natl Acad Sci U S A (2008) 1.70
Influenza-associated mortality in temperate and subtropical Chinese cities, 2003-2008. Bull World Health Organ (2012) 1.69
Chromosome 9p21 haplotypes and prognosis in white and black patients with coronary artery disease. Circ Cardiovasc Genet (2011) 1.69
Urinary interleukin 18 for detection of acute kidney injury: a meta-analysis. Am J Kidney Dis (2013) 1.68
Estimation of cancer incidence and mortality attributable to smoking in China. Cancer Causes Control (2010) 1.68
The role of erythropoietin in regulating angiogenesis. Dev Biol (2004) 1.66
Antitumor activity of targeting SRC kinases in endothelial and myeloid cell compartments of the tumor microenvironment. Clin Cancer Res (2010) 1.64
Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A (2013) 1.64
MicroRNA patterns associated with clinical prognostic parameters and CNS relapse prediction in pediatric acute leukemia. PLoS One (2009) 1.62
Genome of the long-living sacred lotus (Nelumbo nucifera Gaertn.). Genome Biol (2013) 1.59
HTQC: a fast quality control toolkit for Illumina sequencing data. BMC Bioinformatics (2013) 1.58
A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. Hum Mol Genet (2009) 1.56
An adult uterine hemangioblast: evidence for extramedullary self-renewal and clonal bilineage potential. Blood (2010) 1.56
Analyses of differential proteome of human synovial fibroblasts obtained from arthritis. Clin Rheumatol (2008) 1.56
Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. J Biol Chem (2006) 1.53
Analysis of a genomic island housing genes for DNA S-modification system in Streptomyces lividans 66 and its counterparts in other distantly related bacteria. Mol Microbiol (2007) 1.53
Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice. J Hepatol (2012) 1.51
The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells. Cancer Biol Ther (2008) 1.50
Relationship between co-stimulatory molecule B7-H3 expression and gastric carcinoma histology and prognosis. World J Gastroenterol (2006) 1.50
Assessing uncertainty in spatial exposure models for air pollution health effects assessment. Environ Health Perspect (2007) 1.45
Two-year follow-up evaluation of surgical treatment for thoracolumbar fracture-dislocation. Spine (Phila Pa 1976) (2014) 1.44
Aged human cells rejuvenated by cytokine enhancement of biomaterials for surgical ventricular restoration. J Am Coll Cardiol (2012) 1.42
Protective effects of hydrogen-rich saline against erectile dysfunction in a streptozotocin induced diabetic rat model. J Urol (2012) 1.42
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity. Hum Mol Genet (2005) 1.42
Myocardial protection of MCI-186 in rabbit ischemia-reperfusion. Life Sci (2002) 1.40
Myometrial cells induce angiogenesis and salvage damaged myocardium. Am J Physiol Heart Circ Physiol (2006) 1.40
A glucagon-like peptide-1 analog reverses the molecular pathology and cardiac dysfunction of a mouse model of obesity. Circulation (2012) 1.39
Pachyonychia congenita with corneal dystrophy. J Dermatol (2013) 1.39
Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus. PLoS One (2013) 1.38
Prospective study of chemotherapy in combination with cytokine-induced killer cells in patients suffering from advanced non-small cell lung cancer. Anticancer Res (2009) 1.38
Clinical study on the treatment of liver fibrosis due to hepatitis B by IFN-alpha(1) and traditional medicine preparation. World J Gastroenterol (1999) 1.38
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol (2009) 1.36
Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice. Circulation (2004) 1.36
Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains. PLoS Biol (2013) 1.35
COOH-terminal truncated HBV X protein plays key role in hepatocarcinogenesis. Clin Cancer Res (2008) 1.34
BCR-ABL-transformed GMP as myeloid leukemic stem cells. Proc Natl Acad Sci U S A (2008) 1.34
Cryopreservation of organs by vitrification: perspectives and recent advances. Cryobiology (2004) 1.31
Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1. Gut (2010) 1.31
Drinking behaviour among men and women in China: the 2007 China Chronic Disease and Risk Factor Surveillance. Addiction (2011) 1.31
Observation of the nonlocal spin-orbital effective field. Nat Commun (2013) 1.31
The Magnaporthe oryzae avirulence gene AvrPiz-t encodes a predicted secreted protein that triggers the immunity in rice mediated by the blast resistance gene Piz-t. Mol Plant Microbe Interact (2009) 1.30
Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels. Cancer Res (2011) 1.30
Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A (2013) 1.30
Regulation of PRAK subcellular location by p38 MAP kinases. Mol Biol Cell (2003) 1.30
Development and validation of reagents and assays for EZH2 peptide and nucleosome high-throughput screens. J Biomol Screen (2012) 1.30
Judging egocentric distance on the ground: occlusion and surface integration. Perception (2004) 1.29
Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family. J Biol Chem (2003) 1.28
Improved vitrification solutions based on the predictability of vitrification solution toxicity. Cryobiology (2004) 1.28
Efficacy of adjuvant immunotherapy with cytokine-induced killer cells in patients with locally advanced gastric cancer. Cancer Immunol Immunother (2012) 1.27
Prevalence of polycystic ovary syndrome in women in China: a large community-based study. Hum Reprod (2013) 1.27
Antioxidant activity of sulfated polysaccharide fractions extracted from Undaria pinnitafida in vitro. Int J Biol Macromol (2009) 1.26
Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res (2006) 1.25