Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity.

DNA Repair Interacts with Autophagy To Regulate Inflammatory Responses to Pulmonary Hyperoxia. J Immunol (2017) 0.75

Commentary: Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity. Front Microbiol (2017) 0.75

CRISPR control of virulence in Pseudomonas aeruginosa. Cell Res (2017) 0.75

RNA-guided genetic silencing systems in bacteria and archaea. Nature (2012) 17.12

Common virulence factors for bacterial pathogenicity in plants and animals. Science (1995) 11.22

Establishment of Pseudomonas aeruginosa infection: lessons from a versatile opportunist. Microbes Infect (2000) 7.50

Global analysis of mRNA decay and abundance in Escherichia coli at single-gene resolution using two-color fluorescent DNA microarrays. Proc Natl Acad Sci U S A (2002) 6.93

CRISPR-based adaptive and heritable immunity in prokaryotes. Trends Biochem Sci (2009) 5.54

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors. Proc Natl Acad Sci U S A (1999) 5.10

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci U S A (2011) 4.58

Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis. Am J Respir Crit Care Med (2010) 3.83

Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system. EMBO J (2011) 3.81

An updated evolutionary classification of CRISPR-Cas systems. Nat Rev Microbiol (2015) 3.74

In vivo negative selection screen identifies genes required for Francisella virulence. Proc Natl Acad Sci U S A (2007) 3.73

The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol (2009) 3.56

Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure (2009) 3.47

Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa. J Bacteriol (2008) 3.32

Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins. Nature (2015) 2.94

Self-targeting by CRISPR: gene regulation or autoimmunity? Trends Genet (2010) 2.62

A CRISPR/Cas system mediates bacterial innate immune evasion and virulence. Nature (2013) 2.44

Non-identity-mediated CRISPR-bacteriophage interaction mediated via the Csy and Cas3 proteins. J Bacteriol (2011) 2.02

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems. Mol Cell (2015) 1.89

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A (2014) 1.53

CRISPR-Cas systems: beyond adaptive immunity. Nat Rev Microbiol (2014) 1.51

LasR, a transcriptional activator of Pseudomonas aeruginosa virulence genes, functions as a multimer. J Bacteriol (2002) 1.36

RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Mol Cell (2014) 1.32

Cholesterol-rich membrane rafts and Lyn are involved in phagocytosis during Pseudomonas aeruginosa infection. J Immunol (2008) 1.31

Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One (2009) 1.31

A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barré syndrome. Eur J Clin Microbiol Infect Dis (2012) 1.24

Interference with histidyl-tRNA synthetase by a CRISPR spacer sequence as a factor in the evolution of Pelobacter carbinolicus. BMC Evol Biol (2010) 1.23

The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae. MBio (2013) 1.18

Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa. Nucleic Acids Res (2015) 1.17

Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression. Nucleic Acids Res (2014) 1.13

The role of CRISPR-Cas systems in virulence of pathogenic bacteria. Microbiol Mol Biol Rev (2014) 1.12

A method to purify bacteria-containing phagosomes from infected macrophages. Methods Cell Sci (2000) 1.05

The three major types of CRISPR-Cas systems function independently in CRISPR RNA biogenesis in Streptococcus thermophilus. Mol Microbiol (2014) 1.02

Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs. J Immunol (2004) 1.01

MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits. Nat Commun (2014) 0.98

A small-molecule compound targeting CCR5 and CXCR3 prevents airway hyperresponsiveness and inflammation. Eur Respir J (2007) 0.97

Association between Pseudomonas aeruginosa type III secretion, antibiotic resistance, and clinical outcome: a review. Crit Care (2014) 0.96

Role of CFTR, Pseudomonas aeruginosa and Toll-like receptors in cystic fibrosis lung inflammation. Biochem Soc Trans (2009) 0.94

An evolutionary link between natural transformation and CRISPR adaptive immunity. MBio (2012) 0.94

miR-155 suppresses bacterial clearance in Pseudomonas aeruginosa-induced keratitis by targeting Rheb. J Infect Dis (2014) 0.93

TLR4-mediated MyD88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in cortex in mice. Biomed Pharmacother (2008) 0.90

Correlation of Klebsiella pneumoniae comparative genetic analyses with virulence profiles in a murine respiratory disease model. PLoS One (2014) 0.89

Lyn mitigates mouse airway remodeling by downregulating the TGF-β3 isoform in house dust mite models. J Immunol (2013) 0.86

Structure of a highly phosphorylated lipopolysaccharide core in the Delta algC mutants derived from Pseudomonas aeruginosa wild-type strains PAO1 (serogroup O5) and PAC1R (serogroup O3). Carbohydr Res (2003) 0.86

IL-4 inhibits the melanogenesis of normal human melanocytes through the JAK2-STAT6 signaling pathway. J Invest Dermatol (2012) 0.85

Enhancing the potency of HBV DNA vaccines using fusion genes of HBV-specific antigens and the N-terminal fragment of gp96. J Gene Med (2007) 0.84

Lyn Delivers Bacteria to Lysosomes for Eradication through TLR2-Initiated Autophagy Related Phagocytosis. PLoS Pathog (2016) 0.81

The role of Cas8 in type I CRISPR interference. Biosci Rep (2015) 0.81

Annexin A2 Regulates Autophagy in Pseudomonas aeruginosa Infection through the Akt1-mTOR-ULK1/2 Signaling Pathway. J Immunol (2015) 0.81

Genes as early responders regulate quorum-sensing and control bacterial cooperation in Pseudomonas aeruginosa. PLoS One (2014) 0.80

A novel chemosynthetic peptide with β-sheet motif efficiently kills Klebsiella pneumoniae in a mouse model. Int J Nanomedicine (2015) 0.78

Epinephrine enhances the response of macrophages under LPS stimulation. Biomed Res Int (2014) 0.75