β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance.

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🔗 View Article (PMID 27863248)

Published in Cell on November 17, 2016

Authors

Boris Novakovic1, Ehsan Habibi1, Shuang-Yin Wang1, Rob J W Arts2, Robab Davar1, Wout Megchelenbrink1, Bowon Kim1, Tatyana Kuznetsova1, Matthijs Kox3, Jelle Zwaag3, Filomena Matarese1, Simon J van Heeringen4, Eva M Janssen-Megens1, Nilofar Sharifi1, Cheng Wang1, Farid Keramati1, Vivien Schoonenberg1, Paul Flicek5, Laura Clarke5, Peter Pickkers3, Simon Heath6, Ivo Gut6, Mihai G Netea2, Joost H A Martens1, Colin Logie1, Hendrik G Stunnenberg7

Author Affiliations

1: Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
2: Department of Internal Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases (RCI), 6525 GA Nijmegen, the Netherlands.
3: Department of Intensive Care Medicine, Radboud University Medical Center, Radboud Center for Infectious Diseases (RCI), 6500 HB Nijmegen, the Netherlands.
4: Department of Molecular Developmental Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
5: European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
6: Centro Nacional de Análisis Genómico (CNAG), Parc Científic de Barcelona, 08028 Barcelona, Spain.
7: Department of Molecular Biology, Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. Electronic address: h.stunnenberg@ncmls.ru.nl.

Associated clinical trials:

Transcriptional and Immine Parameters of Response to Belinumab | NCT04570306