Natural products as mediators of disease.

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Published in Nat Prod Rep on November 22, 2016

Authors

Neha Garg1, Tal Luzzatto-Knaan, Alexey V Melnik, Andrés Mauricio Caraballo-Rodríguez, Dimitrios J Floros, Daniel Petras, Rachel Gregor, Pieter C Dorrestein, Vanessa V Phelan

Author Affiliations

1: Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, La Jolla, San Diego, CA 92093, USA. pdorrestein@ucsd.edu vanessa.phelan@ucdenver.edu.

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Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes. Infect Immun (1987) 6.47

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