Published in J Am Chem Soc on April 07, 2010
New insights into the formation of fungal aromatic polyketides. Nat Rev Microbiol (2010) 1.59
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
A fungal ketoreductase domain that displays substrate-dependent stereospecificity. Nat Chem Biol (2012) 1.17
Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs. J Biol Chem (2010) 1.17
Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol (2013) 1.11
Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase. J Am Chem Soc (2012) 1.10
Analysis of intact and dissected fungal polyketide synthase-nonribosomal peptide synthetase in vitro and in Saccharomyces cerevisiae. J Am Chem Soc (2010) 1.07
Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation. Chem Biol (2012) 0.99
Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases. Proc Natl Acad Sci U S A (2014) 0.95
Complexity generation in fungal polyketide biosynthesis: a spirocycle-forming P450 in the concise pathway to the antifungal drug griseofulvin. ACS Chem Biol (2013) 0.94
Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase. Chembiochem (2012) 0.92
LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis. Angew Chem Int Ed Engl (2013) 0.92
Genomics-driven discovery of the pneumocandin biosynthetic gene cluster in the fungus Glarea lozoyensis. BMC Genomics (2013) 0.88
Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. J Am Chem Soc (2015) 0.86
Aflatoxin and deconstruction of type I, iterative polyketide synthase function. Nat Prod Rep (2014) 0.86
Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA. ACS Chem Biol (2015) 0.86
Fungal polyketide synthase product chain-length control by partnering thiohydrolase. ACS Chem Biol (2014) 0.85
Insights into the biosynthesis of 12-membered resorcylic acid lactones from heterologous production in Saccharomyces cerevisiae. ACS Chem Biol (2014) 0.85
Investigation of fungal iterative polyketide synthase functions using partially assembled intermediates. J Am Chem Soc (2013) 0.84
Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi. Front Microbiol (2015) 0.82
Recent progress regarding the bioactivities, biosynthesis and synthesis of naturally occurring resorcinolic macrolides. Acta Pharmacol Sin (2014) 0.80
Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products. Toxins (Basel) (2015) 0.79
Production of New Cladosporin Analogues by Reconstitution of the Polyketide Synthases Responsible for the Biosynthesis of this Antimalarial Agent. Angew Chem Int Ed Engl (2015) 0.78
Three New Non-reducing Polyketide Synthase Genes from the Lichen-Forming Fungus Usnea longissima. Mycobiology (2014) 0.76
Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem (2015) 0.75
Biosynthesis: An HR-PKS stereo surprise. Nat Chem Biol (2012) 0.75
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Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets. Org Biomol Chem (2007) 3.37
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J Am Chem Soc (2009) 2.45
Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase. Proc Natl Acad Sci U S A (2006) 2.35
Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae. Appl Environ Microbiol (2006) 1.79
Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol (2007) 1.78
Targeted covalent inactivation of protein kinases by resorcylic acid lactone polyketides. Proc Natl Acad Sci U S A (2006) 1.73
A gene cluster encoding malonyl-CoA decarboxylase (MatA), malonyl-CoA synthetase (MatB) and a putative dicarboxylate carrier protein (MatC) in Rhizobium trifolii--cloning, sequencing, and expression of the enzymes in Escherichia coli. Eur J Biochem (1998) 1.66
Two different polyketide synthase genes are required for synthesis of zearalenone in Gibberella zeae. Mol Microbiol (2005) 1.65
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Initial characterization of a type I fatty acid synthase and polyketide synthase multienzyme complex NorS in the biosynthesis of aflatoxin B(1). Chem Biol (2002) 1.47
Chemistry and biology of mycotoxins and related fungal metabolites. Chem Rev (2009) 1.46
Dissecting non-ribosomal and polyketide biosynthetic machineries using electrospray ionization Fourier-Transform mass spectrometry. Nat Prod Rep (2006) 1.39
Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia. Appl Environ Microbiol (2008) 1.37
Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii. Chem Biol (2008) 1.35
Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect". Chembiochem (2008) 1.16
Molecular modeling and crystal structure of ERK2-hypothemycin complexes. J Struct Biol (2008) 0.99
Drug discovery and natural products: end of an era or an endless frontier? Science (2009) 7.54
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep (2013) 5.38
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell (2002) 5.11
Negative regulation of the deacetylase SIRT1 by DBC1. Nature (2008) 4.29
ncRNA- and Pc2 methylation-dependent gene relocation between nuclear structures mediates gene activation programs. Cell (2011) 4.26
A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods (2006) 3.89
Mass spectral molecular networking of living microbial colonies. Proc Natl Acad Sci U S A (2012) 3.56
Improved graft mesenchymal stem cell survival in ischemic heart with a hypoxia-regulated heme oxygenase-1 vector. J Am Coll Cardiol (2005) 3.40
Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease. Nat Neurosci (2009) 3.24
Discovery of a widely distributed toxin biosynthetic gene cluster. Proc Natl Acad Sci U S A (2008) 3.20
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One (2011) 2.73
Complete reconstitution of a highly reducing iterative polyketide synthase. Science (2009) 2.68
Image-based genome-wide siRNA screen identifies selective autophagy factors. Nature (2011) 2.58
Translating metabolic exchange with imaging mass spectrometry. Nat Chem Biol (2009) 2.47
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem (2002) 2.45
Tembusu virus in ducks, china. Emerg Infect Dis (2011) 2.30
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages. Proc Natl Acad Sci U S A (2008) 2.23
MS/MS networking guided analysis of molecule and gene cluster families. Proc Natl Acad Sci U S A (2013) 2.12
Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein. J Biol Chem (2008) 2.12
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. Nat Chem Biol (2011) 2.05
Imaging mass spectrometry in microbiology. Nat Rev Microbiol (2011) 2.04
A novel intracellular protein delivery platform based on single-protein nanocapsules. Nat Nanotechnol (2009) 1.94
Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc Natl Acad Sci U S A (2010) 1.90
Thuricin CD, a posttranslationally modified bacteriocin with a narrow spectrum of activity against Clostridium difficile. Proc Natl Acad Sci U S A (2010) 1.89
Phosphorylation of Tip60 by GSK-3 determines the induction of PUMA and apoptosis by p53. Mol Cell (2011) 1.87
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. Stem Cells Dev (2009) 1.87
Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis. Proc Natl Acad Sci U S A (2006) 1.80
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A (2014) 1.78
Two-peptide bacteriocins produced by lactic acid bacteria. Biochimie (2002) 1.72
Molecular basis for chloronium-mediated meroterpene cyclization: cloning, sequencing, and heterologous expression of the napyradiomycin biosynthetic gene cluster. J Biol Chem (2007) 1.71
Tgf-Beta signaling in development. Sci STKE (2007) 1.70
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry (2003) 1.70
Structural characterization of lacticin 3147, a two-peptide lantibiotic with synergistic activity. Biochemistry (2004) 1.61
Molecular networking as a dereplication strategy. J Nat Prod (2013) 1.57
Interspecies interactions stimulate diversification of the Streptomyces coelicolor secreted metabolome. MBio (2013) 1.56
Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc (2007) 1.55
Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants. Chem Biol (2012) 1.55
Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology (2005) 1.55
Microbial metabolic exchange--the chemotype-to-phenotype link. Nat Chem Biol (2011) 1.55
A polyketide macrolactone synthase from the filamentous fungus Gibberella zeae. Proc Natl Acad Sci U S A (2008) 1.54
Deconvolution and database search of complex tandem mass spectra of intact proteins: a combinatorial approach. Mol Cell Proteomics (2010) 1.53
Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum. Chem Biol (2010) 1.51
Protection from ischemic heart injury by a vigilant heme oxygenase-1 plasmid system. Hypertension (2004) 1.50
Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives. Biochemistry (2004) 1.50
Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature (2011) 1.50
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression. Ann Neurol (2005) 1.48
Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Mol Biosyst (2008) 1.47
Interkingdom metabolic transformations captured by microbial imaging mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.46
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway. Mech Ageing Dev (2005) 1.46
The evolving field of imaging mass spectrometry and its impact on future biological research. J Mass Spectrom (2011) 1.43
Tailoring nanocarriers for intracellular protein delivery. Chem Soc Rev (2011) 1.42
Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum. J Am Chem Soc (2011) 1.41
Extracellular matrix metalloproteinase inducer (CD147) confers resistance of breast cancer cells to Anoikis through inhibition of Bim. J Biol Chem (2006) 1.41
Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods (2009) 1.41
Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. J Am Chem Soc (2005) 1.40
Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A (2011) 1.40
A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20. Nat Med (2012) 1.40
Magnetic sensors for protease assays. Angew Chem Int Ed Engl (2003) 1.39
Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry (2002) 1.39
Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem (2009) 1.37
Navigating the fungal polyketide chemical space: from genes to molecules. J Org Chem (2012) 1.36
A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis. Proc Natl Acad Sci U S A (2008) 1.36
The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene (2005) 1.35
Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry (2003) 1.35
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Top-down mass spectrometry on low-resolution instruments: characterization of phosphopantetheinylated carrier domains in polyketide and non-ribosomal biosynthetic pathways. Bioorg Med Chem Lett (2007) 1.33
Molecular characterization of propionyllysines in non-histone proteins. Mol Cell Proteomics (2008) 1.33
Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A (2010) 1.33
Cyclophosphamide increases transgene expression mediated by an oncolytic adenovirus in glioma-bearing mice monitored by bioluminescence imaging. Mol Ther (2006) 1.32
Redirecting the cyclization steps of fungal polyketide synthase. J Am Chem Soc (2007) 1.32
Expansion of the mycobacterial "PUPylome". Mol Biosyst (2009) 1.31
Bacterial biosynthesis and maturation of the didemnin anti-cancer agents. J Am Chem Soc (2012) 1.29
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J Biol Chem (2010) 1.28
Ablation of Smurf2 reveals an inhibition in TGF-β signalling through multiple mono-ubiquitination of Smad3. EMBO J (2011) 1.27
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol (2004) 1.27
Marinopyrrole A target elucidation by acyl dye transfer. J Am Chem Soc (2009) 1.26
Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum. J Biol Chem (2010) 1.25
Serine and threonine beta-lactones: a new class of hepatitis A virus 3C cysteine proteinase inhibitors. J Org Chem (2002) 1.25
A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. J Biol Chem (2010) 1.23
Primer on agar-based microbial imaging mass spectrometry. J Bacteriol (2012) 1.22
Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase. J Am Chem Soc (2011) 1.22
Metabolic engineering for the production of natural products. Annu Rev Chem Biomol Eng (2011) 1.22
A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells. J Biol Chem (2006) 1.22
Incorporation of nonmethyl branches by isoprenoid-like logic: multiple beta-alkylation events in the biosynthesis of myxovirescin A1. Chem Biol (2007) 1.21
Imaging mass spectrometry of natural products. Nat Prod Rep (2009) 1.20
Isolation and characterization of carnocyclin a, a novel circular bacteriocin produced by Carnobacterium maltaromaticum UAL307. Appl Environ Microbiol (2008) 1.19
Geographical, seasonal and gender differences in folate status among Chinese adults. J Nutr (2003) 1.19
Regeneration of the cavernous nerve by Sonic hedgehog using aligned peptide amphiphile nanofibers. Biomaterials (2010) 1.18
Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol (2011) 1.18
Acyltransferase mediated polyketide release from a fungal megasynthase. J Am Chem Soc (2009) 1.18