Published in Nat Commun on December 08, 2016
Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature (2004) 11.59
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature (2007) 7.72
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48
mTOR is a key modulator of ageing and age-related disease. Nature (2013) 5.40
Age-associated characteristics of murine hematopoietic stem cells. J Exp Med (2000) 4.65
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche. Blood (2007) 4.49
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal (2009) 3.94
Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. Nat Med (2014) 2.99
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature (2014) 2.67
A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature (2013) 2.62
p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice. Nat Med (2014) 2.60
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell (2012) 2.60
Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b. Mol Cell (2002) 2.51
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein. Nat Med (2003) 2.42
Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell (2014) 2.24
The ageing haematopoietic stem cell compartment. Nat Rev Immunol (2013) 2.15
VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene (2003) 2.08
Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat Med (2014) 2.05
Isothermal titration calorimetry of protein-protein interactions. Methods (1999) 2.03
Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging. Cell Stem Cell (2013) 1.97
Mechanisms that regulate stem cell aging and life span. Cell Stem Cell (2013) 1.73
SIRT3 reverses aging-associated degeneration. Cell Rep (2013) 1.65
MAPK signaling pathways in the regulation of hematopoiesis. J Leukoc Biol (2009) 1.60
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase. J Exp Med (2006) 1.53
Causes, consequences, and reversal of immune system aging. J Clin Invest (2013) 1.50
Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres. Blood (2014) 1.46
p38MAPK controls expression of multiple cell cycle inhibitors and islet proliferation with advancing age. Dev Cell (2009) 1.40
Selectivity of docking sites in MAPK kinases. J Biol Chem (2009) 1.36
SALL4 is a robust stimulator for the expansion of hematopoietic stem cells. Blood (2011) 1.34
VDUP1 is required for the development of natural killer cells. Immunity (2005) 1.31
Reactive oxygen species and hematopoietic stem cell senescence. Int J Hematol (2011) 1.24
HIF-1α deletion partially rescues defects of hematopoietic stem cell quiescence caused by Cited2 deficiency. Blood (2012) 1.10
Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev (2011) 1.09
Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging (Albany NY) (2014) 0.99
Inhibition of p38 MAPK activity promotes ex vivo expansion of human cord blood hematopoietic stem cells. Ann Hematol (2012) 0.98
Thioredoxin-interacting protein regulates hematopoietic stem cell quiescence and mobilization under stress conditions. J Immunol (2009) 0.96
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence. J Clin Invest (2014) 0.95
TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells. Blood (2010) 0.93
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein. Nat Commun (2014) 0.87
TXNIP maintains the hematopoietic cell pool by switching the function of p53 under oxidative stress. Cell Metab (2013) 0.83
Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxid Med Cell Longev (2015) 0.82
Loss of SPARC protects hematopoietic stem cells from chemotherapy toxicity by accelerating their return to quiescence. Blood (2014) 0.81
Hematopoietic stem cells: an overview. Transfus Apher Sci (2014) 0.81
Expansion of human and murine hematopoietic stem and progenitor cells ex vivo without genetic modification using MYC and Bcl-2 fusion proteins. PLoS One (2014) 0.80
Enhanced hematopoietic stem cell function mediates immune regeneration following sex steroid blockade. Stem Cell Reports (2015) 0.80
Inhibition of inflammation by a p38 MAP kinase targeted cell permeable peptide. Med Chem (2008) 0.79
Thioredoxin-interacting protein, hematopoietic stem cells, and hematopoiesis. Curr Opin Hematol (2014) 0.77
The potential role of cell penetrating peptides in the intracellular delivery of proteins for therapy of erythroid related disorders. Pharmaceuticals (Basel) (2013) 0.76