SYN-004 (ribaxamase), an oral β-lactamase designed to protect the gut microbiome from the deleterious effects of certain intravenously administered β-lactam antibiotics, degrades ceftriaxone excreted into the intestine in Phase 2a clinical studies.

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Published in Antimicrob Agents Chemother on January 04, 2017

Authors

John F Kokai-Kun1, Tracey Roberts2, Olivia Coughlin2, Eric Sicard3, Marianne Rufiange3, Richard Fedorak4, Christian Carter4, Marijke H Adams5, James Longstreth6, Heidi Whalen2, Joseph Sliman2

Author Affiliations

1: Synthetic Biologics, Inc., Rockville, MD jkokai-kun@syntheticbiologics.com.
2: Synthetic Biologics, Inc., Rockville, Maryland, USA.
3: Algorithme Pharma, Laval, Quebec, Canada.
4: University of Alberta/Alberta Health Service, Edmonton, Alberta, Canada.
5: MH Adams & Associates, Inc., Davie, Florida, USA.
6: Longstreth and Associates, Inc., Mundelein, Illinois, USA.

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