Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women.

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Published in Immunity on January 09, 2017

Authors

Christina Gosmann1, Melis N Anahtar1, Scott A Handley2, Mara Farcasanu3, Galeb Abu-Ali4, Brittany A Bowman3, Nikita Padavattan5, Chandni Desai2, Lindsay Droit2, Amber Moodley6, Mary Dong7, Yuezhou Chen8, Nasreen Ismail5, Thumbi Ndung'u9, Musie S Ghebremichael1, Duane R Wesemann8, Caroline Mitchell10, Krista L Dong7, Curtis Huttenhower4, Bruce D Walker11, Herbert W Virgin2, Douglas S Kwon12

Author Affiliations

1: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Harvard Medical School, Boston, MA 02115, USA.
2: Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
3: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA.
4: Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
5: HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, 4001, South Africa.
6: Females Rising through Education, Support, and Health, Durban, KwaZulu-Natal, 4066, South Africa.
7: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Females Rising through Education, Support, and Health, Durban, KwaZulu-Natal, 4066, South Africa.
8: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
9: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; HIV Pathogenesis Programme, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, KwaZulu-Natal, 4001, South Africa.
10: Vincent Obstetrics & Gynecology, Massachusetts General Hospital, Boston, MA 02115, USA.
11: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02115, USA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
12: Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Cambridge, MA 02139, USA; Harvard Medical School, Boston, MA 02115, USA; Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02115, USA. Electronic address: dkwon@mgh.harvard.edu.

Associated clinical trials:

Microbiome in Preterm Birth | NCT04489056

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