Published in PLoS One on January 26, 2017
Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet (1998) 3.96
An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature (1997) 3.87
Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene. Proc Natl Acad Sci U S A (1985) 3.24
Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem (2006) 2.07
Purification and characterization of a complex containing matriptase and a Kunitz-type serine protease inhibitor from human milk. J Biol Chem (1999) 1.93
Trypsin-pancreatic trypsin inhibitor association. Dynamics of the interaction and role of disulfide bridges. Biochemistry (1972) 1.76
Characterization of matriptase expression in normal human tissues. J Histochem Cytochem (2003) 1.74
The activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitor. J Biol Chem (2003) 1.71
HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. Am J Physiol Cell Physiol (2005) 1.56
Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second protease. Am J Physiol Renal Physiol (2014) 1.52
Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway. Proc Natl Acad Sci U S A (2007) 1.52
Regulation of the activity of matriptase on epithelial cell surfaces by a blood-derived factor. Eur J Biochem (2001) 1.49
Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1. J Am Soc Nephrol (2006) 1.48
Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene (2006) 1.47
Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. J Biol Chem (2001) 1.43
Serpin-protease complexes are trapped as stable acyl-enzyme intermediates. J Biol Chem (1995) 1.40
Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development (2009) 1.38
Characterization of a novel, membrane-bound, 80-kDa matrix-degrading protease from human breast cancer cells. Monoclonal antibody production, isolation, and localization. J Biol Chem (1997) 1.36
Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. J Biol Chem (1995) 1.35
Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. FEBS Lett (2005) 1.34
Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (2007) 1.32
Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem (2008) 1.31
Biochemical characterization of prostasin, a channel activating protease. Biochem Biophys Res Commun (2004) 1.30
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. Am J Physiol Cell Physiol (2004) 1.29
Matriptase activation, an early cellular response to acidosis. J Biol Chem (2009) 1.24
Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. J Biol Chem (1997) 1.24
Regulation of prostasin expression and function in the prostate. Prostate (2004) 1.23
Distribution of hepatocyte growth factor activator inhibitor type 1 (HAI-1) in human tissues. Cellular surface localization of HAI-1 in simple columnar epithelium and its modulated expression in injured and regenerative tissues. J Histochem Cytochem (1999) 1.22
Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol (2009) 1.20
Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation. J Biol Chem (2010) 1.19
Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea. Lancet (1985) 1.18
Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet (2012) 1.16
Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Am J Hum Genet (2009) 1.15
Regulation of electroneutral NaCl absorption by the small intestine. Annu Rev Physiol (2011) 1.15
A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation. J Biol Chem (2013) 1.09
Congenital Na+ diarrhea: a new type of secretory diarrhea. J Pediatr (1985) 1.03
Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains. J Biol Chem (1997) 1.03
TMPRSS2, a serine protease expressed in the prostate on the apical surface of luminal epithelial cells and released into semen in prostasomes, is misregulated in prostate cancer cells. Am J Pathol (2010) 0.97
Mechanisms for the control of matriptase activity in the absence of sufficient HAI-1. Am J Physiol Cell Physiol (2011) 0.92
Increased matriptase zymogen activation in inflammatory skin disorders. Am J Physiol Cell Physiol (2010) 0.89
Conserved expression of hepatocyte growth factor activator inhibitor type-2/placental bikunin in human colorectal carcinomas. Cancer Lett (2000) 0.88
The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem (2014) 0.86
Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. J Invest Dermatol (2013) 0.84
Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation. PLoS One (2016) 0.84
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. PLoS One (2014) 0.83
Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cells. PLoS One (2015) 0.83
Case of syndromic tufting enteropathy harbors SPINT2 mutation seen in congenital sodium diarrhea. Clin Dysmorphol (2010) 0.81
The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition. FASEB J (2014) 0.81
Pre-existence of the active site in zymogens, the interaction of trypsinogen with the basic pancreatic trypsin inhibitor (Kunitz). FEBS Lett (1976) 0.81
N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental Bikunin. PLoS One (2015) 0.81
Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin. J Biol Chem (2015) 0.78
Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin. Development (2016) 0.76
Matriptase regulates proliferation and early, but not terminal, differentiation of human keratinocytes. J Invest Dermatol (2013) 0.84
Matriptase autoactivation is tightly regulated by the cellular chemical environments. PLoS One (2014) 0.80
Natural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner. PLoS One (2016) 0.75