Published in Cell Death Dis on February 02, 2017
Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Front Oncol (2017) 0.75
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids. J Exp Clin Cancer Res (2017) 0.75
Obesity and Cancer Metabolism: A Perspective on Interacting Tumor-Intrinsic and Extrinsic Factors. Front Oncol (2017) 0.75
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet (2008) 20.62
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev (2001) 15.97
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol (2011) 15.71
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Autophagy regulates lipid metabolism. Nature (2009) 13.33
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature (2002) 8.77
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium. Gastroenterology (2011) 6.36
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer (2012) 6.14
Cancer metabolism: fatty acid oxidation in the limelight. Nat Rev Cancer (2013) 2.59
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature (2016) 2.50
Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene (2008) 2.48
Defective regulation of autophagy upon leucine deprivation reveals a targetable liability of human melanoma cells in vitro and in vivo. Cancer Cell (2011) 2.24
Obesity is an independent prognostic variable in colon cancer survivors. Clin Cancer Res (2010) 2.18
Metabolic control of autophagy. Cell (2014) 1.90
Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta (2013) 1.85
Regulation of lipid stores and metabolism by lipophagy. Cell Death Differ (2012) 1.80
Retaining cell-cell contact enables preparation and culture of spheroids composed of pure primary cancer cells from colorectal cancer. Proc Natl Acad Sci U S A (2011) 1.63
Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer Sci (2010) 1.49
Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol (2009) 1.36
Adiposity and cancer risk: new mechanistic insights from epidemiology. Nat Rev Cancer (2015) 1.32
Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice. Proc Natl Acad Sci U S A (1997) 1.29
Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol (2012) 1.25
Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy. Cancer (2013) 1.25
Complete deletion of Apc results in severe polyposis in mice. Oncogene (2009) 1.16
PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. Gastroenterology (2014) 1.13
Obesity and cancer: local and systemic mechanisms. Annu Rev Med (2015) 1.09
Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res (1998) 1.06
Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovasc Res (2008) 0.97
Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. Mol Cell Biol (2013) 0.94
Autophagosomes contribute to intracellular lipid distribution in enterocytes. Mol Biol Cell (2013) 0.89
Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice. Int J Obes (Lond) (2011) 0.88
Wnt signaling in cancer stem cells and colon cancer metastasis. F1000Res (2016) 0.84
Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer. Cancer Res (2016) 0.82
Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochim Biophys Acta (2015) 0.80
Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells. Endocrinology (2007) 0.76
Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells. Oncotarget (2015) 0.81
PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells. Oncotarget (2016) 0.79
Ketogenesis contributes to intestinal cell differentiation. Cell Death Differ (2016) 0.75