Published in J Physiol on March 22, 2017
Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science (2000) 15.16
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol (2010) 3.91
PIP2 is a necessary cofactor for ion channel function: how and why? Annu Rev Biophys (2008) 3.89
The neurobiology of itch. Nat Rev Neurosci (2006) 3.25
TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch. Nat Neurosci (2011) 3.05
TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms. Proc Natl Acad Sci U S A (2009) 2.96
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nat Med (2004) 2.71
TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J Neurosci (2007) 2.69
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem (2006) 2.65
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48
Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 2.47
Behavioral differentiation between itch and pain in mouse. Pain (2008) 2.37
Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology (2010) 2.18
Dissection of the components for PIP2 activation and thermosensation in TRP channels. Proc Natl Acad Sci U S A (2007) 2.02
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Phospholipase Cbeta 3 mediates the scratching response activated by the histamine H1 receptor on C-fiber nociceptive neurons. Neuron (2006) 1.84
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation. Proc Natl Acad Sci U S A (2010) 1.80
Aiming drug discovery at lysophosphatidic acid targets. Br J Pharmacol (2010) 1.73
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. Cell (2013) 1.71
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron (2015) 1.69
Phospholipase D: enzymology, functionality, and chemical modulation. Chem Rev (2011) 1.66
Neural processing of itch. Neuroscience (2013) 1.32
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
Mammalian phospholipase C. Annu Rev Physiol (2012) 1.28
The TGR5 receptor mediates bile acid-induced itch and analgesia. J Clin Invest (2013) 1.27
Short-chain phosphatidates are subtype-selective antagonists of lysophosphatidic acid receptors. Mol Pharmacol (2001) 1.27
Lysophospholipid receptor nomenclature review: IUPHAR Review 8. Br J Pharmacol (2014) 1.21
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol (2013) 1.18
Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site. Nat Chem Biol (2011) 1.16
Facial injections of pruritogens and algogens excite partly overlapping populations of primary and second-order trigeminal neurons in mice. J Neurophysiol (2010) 1.15
Direct activation of transient receptor potential vanilloid 1(TRPV1) by diacylglycerol (DAG). Mol Pain (2008) 1.15
Phospholipase C mediated modulation of TRPV1 channels. Mol Neurobiol (2008) 1.15
Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons. Proc Natl Acad Sci U S A (2011) 1.10
Tricyclodecan-9-yl-xanthogenate (D609) mechanism of actions: a mini-review of literature. Neurochem Res (2011) 1.03
Itch mechanisms and circuits. Annu Rev Biophys (2014) 1.01
Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proc Natl Acad Sci U S A (2013) 0.99
Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model. Neurosci Lett (2010) 0.98
New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? Pflugers Arch (2013) 0.97
Measurement of plasma lysophosphatidic acid concentration in healthy subjects: strong correlation with lysophospholipase D activity. Ann Clin Biochem (2008) 0.95
The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice. Gastroenterology (2014) 0.93
Purification of a phosphatidic-acid-hydrolysing phospholipase A2 from rat brain. Biochem J (1995) 0.92
HTR7 Mediates Serotonergic Acute and Chronic Itch. Neuron (2015) 0.92
A ménage à trois made in heaven: G-protein-coupled receptors, lipids and TRP channels. Cell Calcium (2011) 0.86
Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice. Biol Pharm Bull (2008) 0.85
Potentiation of the transient receptor potential vanilloid 1 channel contributes to pruritogenesis in a rat model of liver disease. J Biol Chem (2013) 0.83
TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂. Nat Commun (2014) 0.82
Itch-scratch responses induced by lysophosphatidic acid in mice. Pharmacology (2004) 0.81
Targeting TRP ion channels for itch relief. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.78