Published in Oncotarget on February 07, 2017
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature (1998) 15.09
DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res (2007) 13.94
Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem (1999) 11.87
A gene network regulating lysosomal biogenesis and function. Science (2009) 7.17
Cathepsin-D in primary breast cancer: prognostic evaluation involving 2810 patients. Br J Cancer (1999) 5.47
Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell (2001) 5.12
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol (2011) 4.96
Lysosomes behave as Ca2+-regulated exocytic vesicles in fibroblasts and epithelial cells. J Cell Biol (1997) 3.31
Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis. Int J Biochem Cell Biol (2006) 3.24
Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol (2013) 3.13
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy (2012) 2.87
Transcriptional activation of lysosomal exocytosis promotes cellular clearance. Dev Cell (2011) 2.71
Membrane proximal lysosomes are the major vesicles responsible for calcium-dependent exocytosis in nonsecretory cells. J Cell Biol (2002) 2.65
Regulated secretion of conventional lysosomes. Trends Cell Biol (2000) 2.34
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis. Cancer Lett (2005) 2.10
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase. Cancer Cell (2013) 2.09
Heparanase as mediator of angiogenesis: mode of action. FASEB J (2001) 2.04
Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB. Nat Cell Biol (2015) 1.88
Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res (2005) 1.76
Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy. Cancer Res (2015) 1.59
Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? Trends Biochem Sci (1991) 1.57
Actin filaments and myosin I alpha cooperate with microtubules for the movement of lysosomes. Mol Biol Cell (2001) 1.56
Lysosomal cell death at a glance. J Cell Sci (2013) 1.50
Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J Biol Chem (2013) 1.49
Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood (2006) 1.48
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Cathepsin L is responsible for processing and activation of proheparanase through multiple cleavages of a linker segment. J Biol Chem (2008) 1.43
Lysosomal sequestration of sunitinib: a novel mechanism of drug resistance. Clin Cancer Res (2011) 1.40
A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis. Dev Cell (2013) 1.36
Lysosomal physiology. Annu Rev Physiol (2015) 1.34
Cathepsin D: a cellular roadmap. Biochem Biophys Res Commun (2008) 1.33
Heparanase accelerates wound angiogenesis and wound healing in mouse and rat models. FASEB J (2005) 1.32
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene (2001) 1.19
Heterodimer formation is essential for heparanase enzymatic activity. Biochem Biophys Res Commun (2003) 1.17
Activation, processing and trafficking of extracellular heparanase by primary human fibroblasts. J Cell Sci (2002) 1.12
Lysosomal sequestration of amine-containing drugs: analysis and therapeutic implications. J Pharm Sci (2007) 1.11
Cancer-associated lysosomal changes: friends or foes? Oncogene (2012) 1.10
The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics. Front Oncol (2014) 1.08
Depletion of major vault protein increases doxorubicin sensitivity and nuclear accumulation and disrupts its sequestration in lysosomes. Mol Cancer Ther (2007) 1.07
Lysosomal sequestration (trapping) of lipophilic amine (cationic amphiphilic) drugs in immortalized human hepatocytes (Fa2N-4 cells). Drug Metab Dispos (2013) 1.06
Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity? Biochimie (2010) 1.05
Combating apoptosis and multidrug resistant cancers by targeting lysosomes. Cancer Lett (2010) 1.05
Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. PLoS One (2014) 1.04
P-glycoprotein mediates drug resistance via a novel mechanism involving lysosomal sequestration. J Biol Chem (2013) 1.01
Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability. Eur J Biochem (1995) 1.00
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B. J Biochem (2006) 1.00
Heparanase regulates murine hair growth. Am J Pathol (2005) 0.97
Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers. Cell Death Dis (2012) 0.95
Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate. J Immunol (2004) 0.89
Efficacy of ST1968 (namitecan) on a topotecan-resistant squamous cell carcinoma. Biochem Pharmacol (2010) 0.88
High-affinity small molecule-phospholipid complex formation: binding of siramesine to phosphatidic acid. J Am Chem Soc (2008) 0.88
Transport of anthracyclines and mitoxantrone across membranes by a flip-flop mechanism. Biochem Pharmacol (2005) 0.87
Heparanase: a rainbow pharmacological target associated to multiple pathologies including rare diseases. Future Med Chem (2016) 0.87
Optogenetic acidification of synaptic vesicles and lysosomes. Nat Neurosci (2015) 0.85
Lysosomal and cytosolic pH as regulators of exocytosis in mouse macrophages. Acta Physiol Scand (1997) 0.84
Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation. Mol Pharmacol (2005) 0.84
Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance. Oncotarget (2015) 0.84
Regulated lysosomal exocytosis mediates cancer progression. Sci Adv (2015) 0.83
Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration. Mol Pharmacol (1999) 0.83
Lysosomes as mediators of drug resistance in cancer. Drug Resist Updat (2015) 0.83
Lysosomes in cancer-living on the edge (of the cell). Curr Opin Cell Biol (2016) 0.77
ATP release through lysosomal exocytosis from peripheral nerves: the effect of lysosomal exocytosis on peripheral nerve degeneration and regeneration after nerve injury. Biomed Res Int (2014) 0.76
Western blotting and isoform analysis of cathepsin D from normal and malignant human breast cell lines. Breast Cancer Res Treat (1995) 0.76
Structural characterisation and dehydration behaviour of siramesine hydrochloride. J Pharm Sci (2009) 0.76
Lysosomes as mediators of drug resistance in cancer. Drug Resist Updat (2015) 0.83
Binding of a Smad4/Ets-1 complex to a novel intragenic regulatory element in exon12 of FPGS underlies decreased gene expression and antifolate resistance in leukemia. Oncotarget (2014) 0.79
Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics. Drug Resist Updat (2016) 0.77
The importance of breast cancer resistance protein to the kidneys excretory function and chemotherapeutic resistance. Drug Resist Updat (2017) 0.76
A mechanopharmacology approach to overcome chemoresistance in pancreatic cancer. Drug Resist Updat (2017) 0.75