Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy.

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Published in Cell Mol Gastroenterol Hepatol on June 17, 2015

Authors

Atsushi Ono1, Akihiro Fujimoto2, Yujiro Yamamoto3, Sakura Akamatsu1, Nobuhiko Hiraga4, Michio Imamura4, Tomokazu Kawaoka4, Masataka Tsuge4, Hiromi Abe1, C Nelson Hayes1, Daiki Miki5, Mayuko Furuta3, Tatsuhiko Tsunoda6, Satoru Miyano7, Michiaki Kubo8, Hiroshi Aikata4, Hidenori Ochi1, Yoshi-Iku Kawakami4, Koji Arihiro9, Hideki Ohdan10, Hidewaki Nakagawa3, Kazuaki Chayama1

Author Affiliations

1: Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan; Liver Research Project Center, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan.
2: Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan; Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
3: Laboratory for Genome Sequencing Analysis, RIKEN Center for Integrative Medical Sciences, Tokyo, Japan.
4: Department of Gastroenterology and Metabolism, Applied Life Science, Institute of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan; Liver Research Project Center, Hiroshima University, Hiroshima, Japan.
5: Liver Research Project Center, Hiroshima University, Hiroshima, Japan; Laboratory for Digestive Diseases, RIKEN Center for Integrative Medical Sciences, Hiroshima, Japan.
6: Laboratory for Medical Science Mathematics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
7: Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
8: Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
9: Department of Anatomical Pathology, Hiroshima University School of Medicine, Hiroshima, Japan.
10: Department of Gastroenterological Surgery, Hiroshima University School of Medicine, Hiroshima, Japan.

Associated clinical trials:

Analysis of cfDNA in Patients With Hepatocarcinoma and Treated by Sorafenib or Regorafenib (HELP) | NCT03956940

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