Published in Cell Metab on April 07, 2010
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance. Cell Metab (2012) 2.76
Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. J Clin Invest (2010) 2.32
Central neural regulation of brown adipose tissue thermogenesis and energy expenditure. Cell Metab (2014) 1.85
Endocannabinoids in liver disease. Hepatology (2011) 1.27
The case for peripheral CB₁ receptor blockade in the treatment of visceral obesity and its cardiometabolic complications. Br J Pharmacol (2011) 1.21
Alterations in the hippocampal endocannabinoid system in diet-induced obese mice. J Neurosci (2010) 1.19
2-arachidonoylglycerol signaling in forebrain regulates systemic energy metabolism. Cell Metab (2012) 1.09
The thrifty lipids: endocannabinoids and the neural control of energy conservation. Trends Neurosci (2012) 1.08
New insights on the role of the endocannabinoid system in the regulation of energy balance. Int J Obes (Lond) (2015) 1.00
Central endocannabinoid signaling regulates hepatic glucose production and systemic lipolysis. Diabetes (2011) 1.00
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The highs and lows of cannabinoid receptor expression in disease: mechanisms and their therapeutic implications. Pharmacol Rev (2011) 0.99
Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB₁ receptor blockade. Proc Natl Acad Sci U S A (2013) 0.96
Central nervous system regulation of brown adipose tissue. Compr Physiol (2014) 0.93
Neuroendocrine circuits governing energy balance and stress regulation: functional overlap and therapeutic implications. Cell Metab (2014) 0.92
Endocannabinoids - at the crossroads between the gut microbiota and host metabolism. Nat Rev Endocrinol (2015) 0.92
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Intestinal lipid-derived signals that sense dietary fat. J Clin Invest (2015) 0.85
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Cannabinoid receptor 1 in the vagus nerve is dispensable for body weight homeostasis but required for normal gastrointestinal motility. J Neurosci (2012) 0.83
Stress regulates endocannabinoid-CB1 receptor signaling. Semin Immunol (2014) 0.82
CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin. Mol Metab (2014) 0.82
Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. PLoS One (2012) 0.81
Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors. PLoS One (2014) 0.81
Beneficial metabolic effects of CB1R anti-sense oligonucleotide treatment in diet-induced obese AKR/J mice. PLoS One (2012) 0.80
Multiple sleep alterations in mice lacking cannabinoid type 1 receptors. PLoS One (2014) 0.80
Nonhuman primates and other animal models in diabetes research. J Diabetes Sci Technol (2012) 0.79
Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity. Sci Rep (2015) 0.79
Developmental role for endocannabinoid signaling in regulating glucose metabolism and growth. Diabetes (2013) 0.79
Perspectives of CB1 Antagonist in Treatment of Obesity: Experience of RIO-Asia. J Obes (2010) 0.79
Diacylglycerol Lipase α Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Front Endocrinol (Lausanne) (2015) 0.79
A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proc Natl Acad Sci U S A (2014) 0.79
Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression. Int J Neuropsychopharmacol (2015) 0.78
Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation. J Lipid Res (2016) 0.78
Lipid signaling and fat storage in the dark-eyed junco. Gen Comp Endocrinol (2017) 0.75
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Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus. Mol Metab (2017) 0.75
Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling. Pharmacol Ther (2017) 0.75
Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome. Mol Metab (2016) 0.75
New horizons on the role of cannabinoid CB1 receptors in palatable food intake, obesity and related dysmetabolism. Int J Obes Suppl (2014) 0.75
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat Genet (2009) 8.11
Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science (2006) 7.35
The endogenous cannabinoid system controls extinction of aversive memories. Nature (2002) 7.19
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (2003) 6.66
Endocannabinoid-mediated control of synaptic transmission. Physiol Rev (2009) 5.56
CB1 cannabinoid receptors and on-demand defense against excitotoxicity. Science (2003) 5.22
Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science (2002) 4.78
The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron (2006) 4.12
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology (2004) 4.05
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest (2003) 3.62
The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Neuron (2010) 3.28
Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice. J Clin Invest (2008) 3.13
Paracrine activation of hepatic CB1 receptors by stellate cell-derived endocannabinoids mediates alcoholic fatty liver. Cell Metab (2008) 2.91
The emerging role of the endocannabinoid system in endocrine regulation and energy balance. Endocr Rev (2005) 2.90
Results of a multicenter study of 1,057 cases of rectal cancer treated by laparoscopic surgery. Surg Endosc (2008) 2.88
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci (2007) 2.78
Prognostic relevance of 18-F FDG PET/CT in newly diagnosed multiple myeloma patients treated with up-front autologous transplantation. Blood (2011) 2.74
Irinotecan plus S-1 (IRIS) versus fluorouracil and folinic acid plus irinotecan (FOLFIRI) as second-line chemotherapy for metastatic colorectal cancer: a randomised phase 2/3 non-inferiority study (FIRIS study). Lancet Oncol (2010) 2.73
Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia. J Clin Endocrinol Metab (2006) 2.72
Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron (2005) 2.66
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum. J Neurosci (2006) 2.66
Complementary roles of cholecystokinin- and parvalbumin-expressing GABAergic neurons in hippocampal network oscillations. J Neurosci (2005) 2.64
Mucosal immune activation in irritable bowel syndrome: gender-dependence and association with digestive symptoms. Am J Gastroenterol (2009) 2.57
The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest (2004) 2.52
Release probability of hippocampal glutamatergic terminals scales with the size of the active zone. Nat Neurosci (2012) 2.49
Leucovorin, fluorouracil, and oxaliplatin plus bevacizumab versus S-1 and oxaliplatin plus bevacizumab in patients with metastatic colorectal cancer (SOFT): an open-label, non-inferiority, randomised phase 3 trial. Lancet Oncol (2013) 2.45
Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2013) 2.43
Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J Clin Invest (2006) 2.38
Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum. J Neurosci (2007) 2.32
Cbln1 is essential for synaptic integrity and plasticity in the cerebellum. Nat Neurosci (2005) 2.29
Chronic intestinal pseudo-obstruction. World J Gastroenterol (2008) 2.29
A 5-year experience of benign pancreatic hyperenzymemia. Pancreas (2014) 2.27
Hardwiring the brain: endocannabinoids shape neuronal connectivity. Science (2007) 2.21
Absence of intestinal microbiota does not protect mice from diet-induced obesity. Br J Nutr (2010) 2.17
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J Biol Chem (2004) 2.17
Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nat Neurosci (2012) 2.15
Open versus laparoscopic resection of primary tumor for incurable stage IV colorectal cancer: a large multicenter consecutive patients cohort study. Ann Surg (2012) 2.12
Laparoscopy-assisted pancreas- and spleen-preserving total gastrectomy for gastric cancer as compared with open total gastrectomy. Surg Endosc (2009) 2.12
Genetic dissection of behavioural and autonomic effects of Delta(9)-tetrahydrocannabinol in mice. PLoS Biol (2007) 2.08
Diffusion-weighted imaging of malignant breast tumors: the usefulness of apparent diffusion coefficient (ADC) value and ADC map for the detection of malignant breast tumors and evaluation of cancer extension. J Comput Assist Tomogr (2005) 2.05
Pharmacological management of obesity: an endocrine Society clinical practice guideline. J Clin Endocrinol Metab (2015) 2.05
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
ADC mapping of benign and malignant breast tumors. Magn Reson Med Sci (2005) 2.02
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab (2010) 2.02
Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1. Nat Neurosci (2011) 2.00
SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses. Nat Neurosci (2008) 1.97
Introducing the German Mouse Clinic: open access platform for standardized phenotyping. Nat Methods (2005) 1.93
The London Classification of gastrointestinal neuromuscular pathology: report on behalf of the Gastro 2009 International Working Group. Gut (2010) 1.89
Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy. J Nucl Med (2009) 1.87
Pregnenolone can protect the brain from cannabis intoxication. Science (2014) 1.85
Is there a role for ¹¹C-choline PET/CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase <1.5 ng/ml? Eur J Nucl Med Mol Imaging (2010) 1.85
T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat Neurosci (2008) 1.79
Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci (2009) 1.77
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain (2010) 1.77
Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity. J Clin Endocrinol Metab (2005) 1.73
Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription. Stroke (2008) 1.72
Diagnostic accuracy of 18F-FDG PET/CT in characterizing ovarian lesions and staging ovarian cancer: correlation with transvaginal ultrasonography, computed tomography, and histology. Nucl Med Commun (2007) 1.72
Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J Inorg Biochem (2005) 1.71
Two distinct classes of muscarinic action on hippocampal inhibitory synapses: M2-mediated direct suppression and M1/M3-mediated indirect suppression through endocannabinoid signalling. Eur J Neurosci (2004) 1.71
Deamidated gliadin peptide antibodies as a routine test for celiac disease: a prospective analysis. J Clin Gastroenterol (2010) 1.70
Identity, distribution, and development of polydendrocytes: NG2-expressing glial cells. J Neurocytol (2003) 1.70
Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J Neurosci (2004) 1.70
Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. J Neurosci (2007) 1.70
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med (2007) 1.69