Published in PLoS One on March 09, 2017
Structure of 20S proteasome from yeast at 2.4 A resolution. Nature (1997) 12.73
A gated channel into the proteasome core particle. Nat Struct Biol (2000) 5.42
Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell (2010) 4.45
MHC class I expression in mice lacking the proteasome subunit LMP-7. Science (1994) 3.17
Structural basis for the activation of 20S proteasomes by 11S regulators. Nature (2000) 3.04
The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell (2001) 2.91
Identification, purification, and characterization of a protein activator (PA28) of the 20 S proteasome (macropain). J Biol Chem (1992) 2.48
Ongoing enterovirus-induced myocarditis is associated with persistent heart muscle infection: quantitative analysis of virus replication, tissue damage, and inflammation. Proc Natl Acad Sci U S A (1992) 2.38
Purification of an 11 S regulator of the multicatalytic protease. J Biol Chem (1992) 2.35
A role for the proteasome regulator PA28alpha in antigen presentation. Nature (1996) 2.30
PA200, a nuclear proteasome activator involved in DNA repair. EMBO J (2002) 2.15
Host and virus determinants of picornavirus pathogenesis and tropism. Nat Rev Microbiol (2005) 2.15
Interferon-gamma induces different subunit organizations and functional diversity of proteasomes. J Biochem (1994) 2.06
Hexameric assembly of the proteasomal ATPases is templated through their C termini. Nature (2009) 1.97
Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis. J Biol Chem (2000) 1.83
Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity. Cell (2012) 1.83
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68
Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta. EMBO J (2001) 1.65
The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J (2000) 1.62
A fluorescent broad-spectrum proteasome inhibitor for labeling proteasomes in vitro and in vivo. Chem Biol (2006) 1.54
Different proteasome subtypes in a single tissue exhibit different enzymatic properties. J Mol Biol (2000) 1.52
Pyrrolidine dithiocarbamate reduces coxsackievirus B3 replication through inhibition of the ubiquitin-proteasome pathway. J Virol (2005) 1.50
Proteasome activator 11S REG or PA28: recombinant REG alpha/REG beta hetero-oligomers are heptamers. Biochemistry (1999) 1.49
PA28αβ reduces size and increases hydrophilicity of 20S immunoproteasome peptide products. Chem Biol (2014) 1.46
Mice completely lacking immunoproteasomes show major changes in antigen presentation. Nat Immunol (2011) 1.45
Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope. J Immunol (2000) 1.44
A Human Trypanosome Suppresses CD8+ T Cell Priming by Dendritic Cells through the Induction of Immune Regulatory CD4+ Foxp3+ T Cells. PLoS Pathog (2016) 1.40
Enhancement of proteasome function by PA28α overexpression protects against oxidative stress. FASEB J (2010) 1.40
Viral myocarditis: from the perspective of the virus. Circulation (2009) 1.33
Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication. Circulation (2001) 1.31
HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation. J Biol Chem (1997) 1.24
Proteasome inhibition reduces coxsackievirus B3 replication in murine cardiomyocytes. Am J Pathol (2003) 1.19
Expression of the proteasome activator PA28 rescues the presentation of a cytotoxic T lymphocyte epitope on melanoma cells. Cancer Res (2002) 1.06
Molecular dissection of the 11S REG (PA28) proteasome activators. Biochimie (2001) 1.06
Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28. Eur J Biochem (2000) 1.02
Stressing the ubiquitin-proteasome system. Cardiovasc Res (2009) 1.01
Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver. Diabetes (2012) 1.00
Coxsackievirus B3 proteins directionally complement each other to downregulate surface major histocompatibility complex class I. J Virol (2007) 0.97
Proteasome inhibition attenuates coxsackievirus-induced myocardial damage in mice. Am J Physiol Heart Circ Physiol (2008) 0.95
beta2-microglobulin-associated regulation of interferon-gamma and virus-specific immunoglobulin G confer resistance against the development of chronic coxsackievirus myocarditis. Am J Pathol (2003) 0.93
Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis. PLoS Pathog (2011) 0.92
PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo. Eur J Immunol (2011) 0.92
Antitopes define preferential proteasomal cleavage site usage. J Biol Chem (2008) 0.92
Proteasome activator PA28 and its interaction with 20 S proteasomes. Arch Biochem Biophys (1996) 0.91
Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation. Eur J Immunol (2014) 0.91
Pronounced up-regulation of the PA28alpha/beta proteasome regulator but little increase in the steady-state content of immunoproteasome during dendritic cell maturation. Eur J Immunol (2001) 0.90
Removal of damaged proteins during ES cell fate specification requires the proteasome activator PA28. Sci Rep (2013) 0.89
Ongoing coxsackievirus myocarditis is associated with increased formation and activity of myocardial immunoproteasomes. Am J Pathol (2006) 0.88
Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib. Mol Pharm (2012) 0.87
Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes. Amino Acids (2009) 0.87
Hepatitis B virus HBx peptide 116-138 and proteasome activator PA28 compete for binding to the proteasome alpha4/MC6 subunit. Biol Chem (2003) 0.84
Ubiquitin-like protein ISG15 (interferon-stimulated gene of 15 kDa) in host defense against heart failure in a mouse model of virus-induced cardiomyopathy. Circulation (2014) 0.84
Enumeration and functional evaluation of virus-specific CD4+ and CD8+ T cells in lymphoid and peripheral sites of coxsackievirus B3 infection. J Virol (2008) 0.82
Differential interferon responses enhance viral epitope generation by myocardial immunoproteasomes in murine enterovirus myocarditis. Am J Pathol (2009) 0.81
Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycle. Front Physiol (2013) 0.81
PA28αβ: the enigmatic magic ring of the proteasome? Biomolecules (2014) 0.81
The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition. Eur J Immunol (2015) 0.81
The immunoproteasome controls the availability of the cardioprotective pattern recognition molecule Pentraxin3. Eur J Immunol (2015) 0.78
Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes. Toxicology (2016) 0.78
Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia. PLoS One (2016) 0.76