Published in Clin Epigenetics on March 09, 2017
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med (2000) 25.49
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet (2009) 18.90
Systematic localization of common disease-associated variation in regulatory DNA. Science (2012) 14.47
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med (1998) 8.47
Microsatellite instability in colorectal cancer. Gastroenterology (2010) 7.39
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nat Genet (2008) 6.75
Immunohistochemistry versus microsatellite instability testing in phenotyping colorectal tumors. J Clin Oncol (2002) 5.91
Charting a dynamic DNA methylation landscape of the human genome. Nature (2013) 5.80
Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology (2008) 5.19
Identification of genetic elements that autonomously determine DNA methylation states. Nat Genet (2011) 4.04
Mutations associated with HNPCC predisposition -- Update of ICG-HNPCC/INSiGHT mutation database. Dis Markers (2004) 3.03
Methylation of CpG in a small region of the hMLH1 promoter invariably correlates with the absence of gene expression. Cancer Res (1999) 2.54
Programming of DNA methylation patterns. Annu Rev Biochem (2012) 2.32
MLH1 -93G>A promoter polymorphism and the risk of microsatellite-unstable colorectal cancer. J Natl Cancer Inst (2007) 2.24
Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. Hum Mol Genet (1996) 1.76
General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res (2010) 1.64
Reconfiguration of nucleosome-depleted regions at distal regulatory elements accompanies DNA methylation of enhancers and insulators in cancer. Genome Res (2014) 1.63
Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors. Genome Res (2011) 1.60
Ontario familial colon cancer registry: methods and first-year response rates. Chronic Dis Can (2000) 1.55
Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut (2013) 1.37
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands. Genome Res (2009) 1.32
Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis. BMC Cancer (2010) 1.22
MLH1-silenced and non-silenced subgroups of hypermutated colorectal carcinomas have distinct mutational landscapes. J Pathol (2013) 1.17
Identification of new differentially methylated genes that have potential functional consequences in prostate cancer. PLoS One (2012) 1.15
Proteome-wide analysis of disease-associated SNPs that show allele-specific transcription factor binding. PLoS Genet (2012) 1.13
Genomic patterns and context specific interpretation of DNA methylation. Curr Opin Genet Dev (2014) 1.05
Estimating the heritability of colorectal cancer. Hum Mol Genet (2014) 1.02
Making sense of GWAS: using epigenomics and genome engineering to understand the functional relevance of SNPs in non-coding regions of the human genome. Epigenetics Chromatin (2015) 0.99
Specific variants in the MLH1 gene region may drive DNA methylation, loss of protein expression, and MSI-H colorectal cancer. PLoS One (2010) 0.95
MLH1 promoter methylation frequency in colorectal cancer patients and related clinicopathological and molecular features. PLoS One (2013) 0.94
Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1. Hum Mol Genet (2013) 0.93
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer. Sci Rep (2015) 0.92
MLH1-93G > A is a risk factor for MSI colorectal cancer. Carcinogenesis (2011) 0.92
Aberrant DNA methylation profiles of inherited and sporadic colorectal cancer. Clin Epigenetics (2015) 0.89
Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression. Epigenetics Chromatin (2014) 0.89
Functional effects of the MLH1-93G>A polymorphism on MLH1/EPM2AIP1 promoter activity. Oncol Rep (2010) 0.87
An integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer. Genome Biol (2015) 0.87
Mutational profiling of colorectal cancers with microsatellite instability. Oncotarget (2015) 0.85
Systematic DNA methylation analysis of multiple cell lines reveals common and specific patterns within and across tissues of origin. Hum Mol Genet (2015) 0.84
MLH1 region polymorphisms show a significant association with CpG island shore methylation in a large cohort of healthy individuals. PLoS One (2012) 0.83
A polymorphism in the hMLH1 gene (-93G-->A) associated with lung cancer susceptibility and prognosis. Int J Mol Med (2010) 0.81
The interplay between DNA methylation and sequence divergence in recent human evolution. Nucleic Acids Res (2015) 0.81
Molecular approach to genetic and epigenetic pathogenesis of early-onset colorectal cancer. World J Gastrointest Oncol (2016) 0.80
A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1. Hum Genet (2015) 0.79
Clinicopathologic Risk Factor Distributions for MLH1 Promoter Region Methylation in CIMP-Positive Tumors. Cancer Epidemiol Biomarkers Prev (2015) 0.79
Cell type-dependent regulation of hMLH1 promoter activity is influenced by the presence of multiple redundant elements. Mol Cancer Res (2003) 0.78
Haplotype defined by the MLH1-93G/A polymorphism is associated with MLH1 promoter hypermethylation in sporadic colorectal cancers. BMC Res Notes (2014) 0.77
Polymorphism of DNA mismatch repair genes in endometrial cancer. Exp Oncol (2015) 0.77
Association between MutL homolog 1 polymorphisms and the risk of colorectal cancer: a meta-analysis. J Cancer Res Clin Oncol (2015) 0.76
The hMLH1 -93G>A promoter polymorphism is associates with outcomes in oral squamous cell carcinoma patients. Ann Surg Oncol (2014) 0.76
Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer. BMC Cancer (2016) 0.76
Explaining the disease phenotype of intergenic SNP through predicted long range regulation. Nucleic Acids Res (2016) 0.76