Published in Clin Epigenetics on December 21, 2015
CancerLocator: non-invasive cancer diagnosis and tissue-of-origin prediction using methylation profiles of cell-free DNA. Genome Biol (2017) 0.76
The dynamic DNA methylation landscape of the mutL homolog 1 shore is altered by MLH1-93G>A polymorphism in normal tissues and colorectal cancer. Clin Epigenetics (2017) 0.75
Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis. Br J Cancer (2017) 0.75
Associations and prognostic implications of Eastern Cooperative Oncology Group performance status and tumoral LINE-1 methylation status in stage III colon cancer patients. Clin Epigenetics (2016) 0.75
Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer. Cell Death Dis (2016) 0.75
The role of LINE-1 methylation in predicting survival among colorectal cancer patients: a meta-analysis. Int J Clin Oncol (2017) 0.75
Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer. Cancer Cell Int (2017) 0.75
Mismatch Repair Proteins Initiate Epigenetic Alterations During Inflammation-Driven Tumorigenesis. Cancer Res (2017) 0.75
Patterns of somatic mutation in human cancer genomes. Nature (2007) 38.41
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
Cancer genome landscapes. Science (2013) 25.33
CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A (1999) 13.02
A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33
Induction of tumors in mice by genomic hypomethylation. Science (2003) 8.86
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res (2004) 7.92
Classification of colorectal cancer based on correlation of clinical, morphological and molecular features. Histopathology (2007) 7.16
Genome-scale analysis of aberrant DNA methylation in colorectal cancer. Genome Res (2011) 4.84
CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations. J Mol Diagn (2006) 3.98
Distinctive pattern of LINE-1 methylation level in normal tissues and the association with carcinogenesis. Oncogene (2004) 3.50
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells. Cancer Res (1994) 3.18
Variation in the mutation rate across mammalian genomes. Nat Rev Genet (2011) 3.09
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One (2007) 2.99
The human LINE-1 retrotransposon creates DNA double-strand breaks. J Mol Biol (2006) 2.77
DNA methylation biomarkers for blood-based colorectal cancer screening. Clin Chem (2007) 2.65
Hypomethylation of ras oncogenes in primary human cancers. Biochem Biophys Res Commun (1983) 2.41
Chromosomal instability correlates with genome-wide DNA demethylation in human primary colorectal cancers. Cancer Res (2006) 2.15
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc Natl Acad Sci U S A (2005) 2.11
Three DNA methylation epigenotypes in human colorectal cancer. Clin Cancer Res (2009) 2.03
Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int J Mol Sci (2013) 2.00
Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease. Mod Pathol (2013) 1.95
Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med (2011) 1.93
CpG island methylation in aberrant crypt foci of the colorectum. Am J Pathol (2002) 1.83
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int J Colorectal Dis (2003) 1.69
Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer (2014) 1.67
LINE-1 hypomethylation during primary colon cancer progression. PLoS One (2011) 1.66
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J Gastroenterol (2004) 1.58
High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer. J Clin Oncol (2015) 1.52
Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50
Aberrant DNA methylation in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Gastroenterology (2010) 1.46
Correlation of tumour BRAF mutations and MLH1 methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification. J Med Genet (2012) 1.45
Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis. Gut (2013) 1.37
Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) (2013) 1.33
Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res (2014) 1.30
A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS One (2012) 1.24
Whole-genome methylation analysis of benign and malignant colorectal tumours. J Pathol (2013) 1.20
Adolescent and young adult colorectal cancer. J Natl Compr Canc Netw (2013) 1.18
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut (2015) 1.17
Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa. Carcinogenesis (2010) 1.16
Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study. PLoS One (2014) 1.15
Genome-scale discovery of DNA-methylation biomarkers for blood-based detection of colorectal cancer. PLoS One (2012) 1.14
Reconfiguration of DNA methylation in aging. Mech Ageing Dev (2015) 1.14
Genomic insights into cancer-associated aberrant CpG island hypermethylation. Brief Funct Genomics (2013) 1.11
Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis. J Natl Cancer Inst (2014) 1.00
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype. Mol Cell (2014) 1.00
Molecular rules governing de novo methylation in cancer. Cancer Res (2014) 0.97
Epigenetic changes in colorectal cancer. Chin J Cancer (2011) 0.94
APC alterations are frequently involved in the pathogenesis of acinar cell carcinoma of the pancreas, mainly through gene loss and promoter hypermethylation. Virchows Arch (2014) 0.94
Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen (2014) 0.93
LINE-1 methylation shows little intra-patient heterogeneity in primary and synchronous metastatic colorectal cancer. BMC Cancer (2012) 0.93
Methylation levels of LINE-1 in primary lesion and matched metastatic lesions of colorectal cancer. Br J Cancer (2013) 0.93
Colorectal cancer in patients aged 30 years or younger. Surg Oncol (1996) 0.91
The CpG island methylator phenotype (CIMP) in colorectal cancer. Gastroenterol Hepatol Bed Bench (2013) 0.89
Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer. Surg Today (2013) 0.87
Diagnostic utility of MS-MLPA in DNA methylation profiling of adenocarcinomas and neuroendocrine carcinomas of the colon-rectum. Virchows Arch (2012) 0.86
Prognostic relevance of aberrant DNA methylation in g1 and g2 pancreatic neuroendocrine tumors. Neuroendocrinology (2014) 0.85
Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study. Gastroenterol Res Pract (2015) 0.81
Microsatellite unstable gastrointestinal neuroendocrine carcinomas: a new clinicopathologic entity. Endocr Relat Cancer (2014) 0.79
DNA hypermethylation appears early and shows increased frequency with dysplasia in Lynch syndrome-associated colorectal adenomas and carcinomas. Clin Epigenetics (2015) 0.79
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer. Br J Cancer (1997) 0.79