Proteome and Protein Network Analyses of Memory T Cells Find Altered Translation and Cell Stress Signaling in Treated Human Immunodeficiency Virus Patients Exhibiting Poor CD4 Recovery.

PubWeight™: 0.78‹?›

🔗 View Article (PMID 28293663)

Published in Open Forum Infect Dis on March 15, 2016

Authors

Sausan Azzam1, Daniela Schlatzer2, Sean Maxwell2, Xiaolin Li2, Douglas Bazdar3, Yanwen Chen4, Robert Asaad3, Jill Barnholtz-Sloan4, Mark R Chance2, Scott F Sieg3

Author Affiliations

1: Center for Proteomics and Bioinformatics; Pulmonary Critical Care and Sleep Medicine.
2: Center for Proteomics and Bioinformatics.
3: Division of Infectious Diseases and HIV Medicine.
4: Department of Epidemiology and Biostatistics , Case Western Reserve University School of Medicine , Cleveland, Ohio.

Articles citing this

A novel microduplication of ARID1B: Clinical, genetic, and proteomic findings. Am J Med Genet A (2017) 0.75

Articles cited by this

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med (1997) 17.51

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med (1997) 10.62

Pathway Commons, a web resource for biological pathway data. Nucleic Acids Res (2010) 9.18

mTOR signaling at a glance. J Cell Sci (2009) 8.66

T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis (2003) 8.00

S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol (2001) 5.29

Selected reaction monitoring-based proteomics: workflows, potential, pitfalls and future directions. Nat Methods (2012) 4.93

CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression. Clin Infect Dis (2006) 4.67

The BioGRID interaction database: 2015 update. Nucleic Acids Res (2014) 4.06

Progressive CD4+ central memory T cell decline results in CD4+ effector memory insufficiency and overt disease in chronic SIV infection. J Exp Med (2007) 3.45

Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis (2009) 3.39

HIV-infected adults with a CD4 cell count greater than 500 cells/mm3 on long-term combination antiretroviral therapy reach same mortality rates as the general population. J Acquir Immune Defic Syndr (2007) 3.38

IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science (2013) 2.68

The actin cytoskeleton in T cell activation. Annu Rev Immunol (2008) 2.62

The eIF2α kinases: their structures and functions. Cell Mol Life Sci (2013) 2.37

Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis (2011) 2.35

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway. Pharmacol Ther (2013) 1.68

Recovery of the immune system with antiretroviral therapy: the end of opportunism? JAMA (1998) 1.68

mTOR: a protein kinase switching between life and death. Pharmacol Res (2004) 1.55

An integrative -omics approach to identify functional sub-networks in human colorectal cancer. PLoS Comput Biol (2010) 1.54

Peripheral S-phase T cells in HIV disease have a central memory phenotype and rarely have evidence of recent T cell receptor engagement. J Infect Dis (2005) 1.47

Actin cytoskeletal dynamics in T lymphocyte activation and migration. J Leukoc Biol (2003) 1.47

Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer. Mol Cell Proteomics (2008) 1.43

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells. J Infect Dis (2011) 1.40

Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J Virol (2013) 1.33

Role of the interferon-inducible gene IFI16 in the etiopathogenesis of systemic autoimmune disorders. Ann N Y Acad Sci (2007) 1.21

S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/β-catenin pathway. PLoS One (2013) 0.99

Long-term mortality in HIV patients virally suppressed for more than three years with incomplete CD4 recovery: a cohort study. BMC Infect Dis (2010) 0.98

Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Mol Cell Proteomics (2012) 0.97

The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology (2012) 0.95

The interferon-inducible gene IFI16 secretome of endothelial cells drives the early steps of the inflammatory response. Eur J Immunol (2010) 0.93

Immune pathology associated with altered actin cytoskeleton regulation. Autoimmunity (2010) 0.92

T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication. PLoS One (2014) 0.92

MOV10 and FMRP regulate AGO2 association with microRNA recognition elements. Cell Rep (2014) 0.91

Risk of clinical progression among patients with immunological nonresponse despite virological suppression after combination antiretroviral treatment. AIDS (2013) 0.91

Immune Activation While on Potent Antiretroviral Therapy Can Predict Subsequent CD4+ T-Cell Increases Through 15 Years of Treatment. HIV Clin Trials (2013) 0.91

mTOR as a multifunctional therapeutic target in HIV infection. Drug Discov Today (2011) 0.90

Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther (2010) 0.85

Urinary protein profiles in a rat model for diabetic complications. Mol Cell Proteomics (2009) 0.85

Discordance between peripheral and colonic markers of inflammation during suppressive ART. J Acquir Immune Defic Syndr (2014) 0.85

A quantitative proteomic approach for detecting protein profiles of activated human myeloid dendritic cells. J Immunol Methods (2011) 0.84

Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice: A Role for PPARalpha. PPAR Res (2010) 0.83

Proteomic and bioinformatics profile of paired human alveolar macrophages and peripheral blood monocytes. Proteomics (2015) 0.82

Central memory CD4 T cells are associated with incomplete restoration of the CD4 T cell pool after treatment-induced long-term undetectable HIV viraemia. J Antimicrob Chemother (2013) 0.82

Increased stability and limited proliferation of CD4+ central memory T cells differentiate nonprogressive simian immunodeficiency virus (SIV) infection of sooty mangabeys from progressive SIV infection of rhesus macaques. J Virol (2014) 0.82

Innate DNA sensing is impaired in HIV patients and IFI16 expression correlates with chronic immune activation. Clin Exp Immunol (2014) 0.82

Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms. Expert Rev Proteomics (2011) 0.81

Increased gelsolin expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine. J Cell Physiol (2000) 0.79

Dysregulation of the Mammalian Target of Rapamycin and p27Kip1 Promotes Intimal Hyperplasia in Diabetes Mellitus. Pharmaceuticals (Basel) (2013) 0.76

Immunity to human immunodeficiency virus (HIV) infection. Clin Dev Immunol (2012) 0.76