PubRank

C B Wollheim

Author PubWeight™ 239.36‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 1992 5.45
2 Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 2005 4.17
3 Is cytosolic ionized calcium regulating neutrophil activation? Science 1983 3.97
4 Regulation of insulin release by calcium. Physiol Rev 1981 3.91
5 Rapid mobilization of Ca2+ from rat insulinoma microsomes by inositol-1,4,5-trisphosphate. Nature 1984 3.35
6 Mitochondrial function in normal and diabetic beta-cells. Nature 2001 3.32
7 Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 1999 2.99
8 Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 1994 2.46
9 Oscillations of cytosolic Ca2+ in pituitary cells due to action potentials. Nature 1987 2.37
10 Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate. J Biol Chem 1984 2.20
11 Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils. J Cell Biol 1984 2.15
12 Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells. J Biol Chem 1999 2.01
13 Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells. J Biol Chem 1987 1.99
14 Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells. J Biol Chem 1986 1.91
15 Stimulated Ca2+ influx raises mitochondrial free Ca2+ to supramicromolar levels in a pancreatic beta-cell line. Possible role in glucose and agonist-induced insulin secretion. J Biol Chem 1993 1.86
16 Regulation of immunoreactive-insulin release from a rat cell line (RINm5F). Biochem J 1983 1.85
17 The small GTP-binding proteins in the cytosol of insulin-secreting cells are complexed to GDP dissociation inhibitor proteins. J Biol Chem 1992 1.84
18 Single islet beta-cell stimulation by nutrients: relationship between pyridine nucleotides, cytosolic Ca2+ and secretion. EMBO J 1990 1.84
19 Glucose and carbachol generate 1,2-diacylglycerols by different mechanisms in pancreatic islets. J Clin Invest 1988 1.82
20 MAFA controls genes implicated in insulin biosynthesis and secretion. Diabetologia 2006 1.80
21 Second messenger function of inositol 1,4,5-trisphosphate. Early changes in inositol phosphates, cytosolic Ca2+, and insulin release in carbamylcholine-stimulated RINm5F cells. J Biol Chem 1986 1.68
22 Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells. Biochem J 1984 1.67
23 Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation. J Clin Invest 1985 1.58
24 VAMP-2 and cellubrevin are expressed in pancreatic beta-cells and are essential for Ca(2+)-but not for GTP gamma S-induced insulin secretion. EMBO J 1995 1.56
25 The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 1982 1.55
26 Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci U S A 1986 1.53
27 Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA(1c) levels in human pancreatic islets. Diabetologia 2010 1.52
28 SNAP-25 is expressed in islets of Langerhans and is involved in insulin release. J Cell Biol 1995 1.48
29 Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 1999 1.45
30 Dynamic pacing of cell metabolism by intracellular Ca2+ transients. J Biol Chem 1994 1.44
31 Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation. J Biol Chem 2001 1.42
32 Ca2+-mediated generation of inositol 1,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate in pancreatic islets. Studies with K+, glucose, and carbamylcholine. J Biol Chem 1987 1.41
33 Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. J Biol Chem 2000 1.41
34 Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP. J Clin Invest 2000 1.41
35 Intracellular degradation of insulin stores by rat pancreatic islets in vitro. An alternative pathway for homeostasis of pancreatic insulin content. J Biol Chem 1980 1.40
36 Correlation between cytosolic free Ca2+ and insulin release in an insulin-secreting cell line. J Biol Chem 1984 1.39
37 Monolayer cell culture of neonatal rat pancreas: an ultrastructural and biochemical study of functioning endocrine cells. J Ultrastruct Res 1973 1.38
38 Long-term exposure of isolated pancreatic islets to mannoheptulose: evidence for insulin degradation in the beta cell. Biochem Pharmacol 1980 1.35
39 Glucagon release induced by pancreatic nerve stimulation in the dog. J Clin Invest 1973 1.35
40 Galanin activates nucleotide-dependent K+ channels in insulin-secreting cells via a pertussis toxin-sensitive G-protein. EMBO J 1989 1.35
41 Video imaging of cytosolic Ca2+ in pancreatic beta-cells stimulated by glucose, carbachol, and ATP. J Biol Chem 1992 1.35
42 A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets. Diabetologia 2012 1.35
43 GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels. J Biol Chem 1988 1.33
44 Glucose, other secretagogues, and nerve growth factor stimulate mitogen-activated protein kinase in the insulin-secreting beta-cell line, INS-1. J Biol Chem 1995 1.33
45 Expression, localization and functional role of small GTPases of the Rab3 family in insulin-secreting cells. J Cell Sci 1996 1.33
46 Effect of disruption of actin filaments by Clostridium botulinum C2 toxin on insulin secretion in HIT-T15 cells and pancreatic islets. Mol Biol Cell 1994 1.32
47 Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction. EMBO J 2000 1.31
48 Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J Clin Invest 1996 1.29
49 Functional differences between rat islets of ventral and dorsal pancreatic origin. J Clin Invest 1982 1.27
50 Subcellular distribution and function of Rab3A, B, C, and D isoforms in insulin-secreting cells. Mol Endocrinol 1999 1.27
51 Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line. EMBO J 1998 1.26
52 Inositol 1,4,5-trisphosphate and intracellular Ca2+ homeostasis in clonal pituitary cells (GH3). Translocation of Ca2+ into mitochondria from a functionally discrete portion of the nonmitochondrial store. J Biol Chem 1986 1.24
53 Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance. J Clin Invest 2000 1.23
54 Signal transduction in insulin secretion: comparison between fuel stimuli and receptor agonists. Ann N Y Acad Sci 1986 1.23
55 Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltage-gated Ca2+ channels in two secretory cell lines, PC12 and RINm5F. J Biol Chem 1986 1.23
56 Calcium-induced insulin release in monolayer culture of the endocrine pancreas. Studies with ionophore A23187. J Biol Chem 1975 1.21
57 The roles of intracellular and extracellular Ca++ in glucose-stimulated biphasic insulin release by rat islets. J Clin Invest 1978 1.21
58 Calcium-calmodulin stimulates inositol 1,4,5-trisphosphate kinase activity from insulin-secreting RINm5F cells. J Biol Chem 1987 1.20
59 Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J 1997 1.19
60 Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells. Diabetes 1998 1.17
61 Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type Ca2+ channels. Mol Pharmacol 1992 1.17
62 Cytosolic free Ca2+ in insulin secreting cells and its regulation by isolated organelles. Experientia 1984 1.16
63 Quinine inhibits Ca2+-independent K+ channels whereas tetraethylammonium inhibits Ca2+-activated K+ channels in insulin-secreting cells. FEBS Lett 1985 1.16
64 Mutational analysis of VAMP domains implicated in Ca2+-induced insulin exocytosis. EMBO J 1996 1.15
65 Direct control of exocytosis by receptor-mediated activation of the heterotrimeric GTPases Gi and G(o) or by the expression of their active G alpha subunits. EMBO J 1995 1.15
66 Purine nucleotides induce regulated secretion of von Willebrand factor: involvement of cytosolic Ca2+ and cyclic adenosine monophosphate-dependent signaling in endothelial exocytosis. Blood 1998 1.14
67 Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells. Proc Natl Acad Sci U S A 1992 1.13
68 Redistribution of ADP-ribosylation factor during stimulation of permeabilized cells with GTP analogues. Biochem J 1991 1.13
69 Regulated von Willebrand factor secretion is associated with agonist-specific patterns of cytoskeletal remodeling in cultured endothelial cells. Arterioscler Thromb Vasc Biol 2000 1.13
70 The regulation of extramitochondrial steady state free Ca2+ concentration by rat insulinoma mitochondria. J Biol Chem 1983 1.12
71 Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay. Diabetologia 1992 1.12
72 The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium. EMBO J 1997 1.11
73 Somatostatin- and epinephrine-induced modifications of 45Ca++ fluxes and insulin release in rat pancreatic islets maintained in tissue culture. J Clin Invest 1977 1.11
74 Islet cyclic AMP levels are not lowered during alpha 2-adrenergic inhibition of insulin release. J Biol Chem 1984 1.11
75 Different requirements for protein kinase C activation and Ca2+-independent insulin secretion in response to guanine nucleotides. Endogenously generated diacylglycerol requires elevated Ca2+ for kinase C insertion into membranes. J Biol Chem 1989 1.10
76 Isolation of pancreatic islets and primary culture of the intact microorgans or of dispersed islet cells. Methods Enzymol 1990 1.08
77 Studies on the dual effects of glucose on 45Ca++ efflux from isolated rat islets. Endocrinology 1978 1.08
78 Stimulation of insulin release from permeabilized HIT-T15 cells by a synthetic peptide corresponding to the effector domain of the small GTP-binding protein rab3. FEBS Lett 1993 1.08
79 Spontaneous and chemoattractant-induced oscillations of cytosolic free calcium in single adherent human neutrophils. J Biol Chem 1988 1.08
80 Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species. Diabetologia 2006 1.07
81 Insulin and glucagon release from monolayer cell cultures of pancreas from newborn rats. Eur J Clin Invest 1973 1.07
82 Reactive oxygen intermediates induce regulated secretion of von Willebrand factor from cultured human vascular endothelial cells. Blood 1995 1.06
83 Secretagogues modulate the calcium concentration in the endoplasmic reticulum of insulin-secreting cells. Studies in aequorin-expressing intact and permeabilized ins-1 cells. J Biol Chem 1999 1.06
84 Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease. Diabetologia 1999 1.06
85 Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells. Biochem J 1987 1.06
86 A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Diabetes 2001 1.06
87 Mitochondrial signals in glucose-stimulated insulin secretion in the beta cell. J Physiol 2000 1.04
88 Possible role for calmodulin in insulin release. Studies with trifluoperazine in rat pancreatic islets. J Clin Invest 1980 1.04
89 Nonselective inhibition of neutrophil functions by sphinganine. J Biol Chem 1987 1.03
90 Suppression of Pdx-1 perturbs proinsulin processing, insulin secretion and GLP-1 signalling in INS-1 cells. Diabetologia 2005 1.03
91 ATP-sensitive K+ channels in an insulin-secreting cell line are inhibited by D-glyceraldehyde and activated by membrane permeabilization. J Membr Biol 1986 1.03
92 Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase. FEBS Lett 1998 1.02
93 Soluble N-ethylmaleimide-sensitive-factor attachment protein and N-ethylmaleimide-insensitive factors are required for Ca2+-stimulated exocytosis of insulin. Biochem J 1996 1.02
94 Von Willebrand factor propeptide as a marker of disease activity in systemic sclerosis (scleroderma). Arthritis Res 2001 1.01
95 Regulation of mitochondrial glycerol-phosphate dehydrogenase by Ca2+ within electropermeabilized insulin-secreting cells (INS-1). Biochim Biophys Acta 1992 1.01
96 Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis. J Cell Sci 2001 1.00
97 The Rab3-interacting molecule RIM is expressed in pancreatic beta-cells and is implicated in insulin exocytosis. FEBS Lett 2000 1.00
98 Regulation of inositol 1,4,5-trisphosphate metabolism in insulin-secreting RINm5F cells. Biochem J 1988 1.00
99 Epinephrine induces von Willebrand factor release from cultured endothelial cells: involvement of cyclic AMP-dependent signalling in exocytosis. Thromb Haemost 1997 1.00
100 Mitochondria respond to Ca2+ already in the submicromolar range: correlation with redox state. Cell Calcium 2002 1.00
101 Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice. Endocrinology 2001 1.00
102 Ca2+ stores in insulin-secreting cells: lack of effect of cADP ribose. Cell Calcium 1994 1.00
103 Blockade of mevalonate production by lovastatin attenuates bombesin and vasopressin potentiation of nutrient-induced insulin secretion in HIT-T15 cells. Probable involvement of small GTP-binding proteins. Biochem J 1993 0.99
104 Reduced insulin secretion and content in VEGF-a deficient mouse pancreatic islets. Exp Clin Endocrinol Diabetes 2008 0.99
105 GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells. J Biol Chem 2001 0.99
106 Somatostatin inhibition of Ca2(+)-induced insulin secretion in permeabilized HIT-T15 cells. Biochem J 1990 0.98
107 Abnormal glucose metabolism accompanies failure of glucose to stimulate insulin release from a rat pancreatic cell line (RINm5F). Biochem J 1983 0.98
108 The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells. Oncogene 2007 0.98
109 Dynamics of Ca2+ and guanosine 5'-[gamma-thio]triphosphate action on insulin secretion from alpha-toxin-permeabilized HIT-T15 cells. Biochem J 1994 0.98
110 Active transport of myo-inositol in rat pancreatic islets. Biochem J 1986 0.97
111 Stimulation of adenylate cyclase by Ca2+ and calmodulin in rat islets of langerhans: explanation for the glucose-induced increase in cyclic AMP levels. Diabetes 1980 0.97
112 Cysteine-string proteins regulate exocytosis of insulin independent from transmembrane ion fluxes. FEBS Lett 1998 0.97
113 Effect of leukotriene B4, prostaglandin E2 and arachidonic acid on cytosolic-free calcium in human neutrophils. FEBS Lett 1984 0.97
114 Thyrotropin-releasing hormone increases cytosolic free Ca2+ in clonal pituitary cells (GH3 cells): direct evidence for the mobilization of cellular calcium. J Cell Biol 1984 0.97
115 Acute von Willebrand factor secretion from the endothelium in vivo: assessment through plasma propeptide (vWf:AgII) Levels. Thromb Haemost 1997 0.96
116 Dependency of cyclic AMP-induced insulin release on intra- and extracellular calcium in rat islets of Langerhans. J Clin Invest 1980 0.96
117 Ca2+-independent insulin exocytosis induced by alpha-latrotoxin requires latrophilin, a G protein-coupled receptor. EMBO J 1998 0.96
118 Ca2+ depletion from granules inhibits exocytosis. A study with insulin-secreting cells. J Biol Chem 1998 0.95
119 Caerulein and carbamoylcholine stimulate pancreatic amylase release at resting cytosolic free Ca2+. Biochem J 1986 0.95
120 Role of mitochondrial calcium in metabolism-secretion coupling in nutrient-stimulated insulin release. Diabetes Metab 1998 0.95
121 Desensitization of mitochondrial Ca2+ and insulin secretion responses in the beta cell. J Biol Chem 1998 0.95
122 Dispersed adult rat pancreatic islet cells in culture: A, B, and D cell function. Metabolism 1984 0.94
123 Galanin inhibits insulin secretion by direct interference with exocytosis. FEBS Lett 1989 0.94
124 Monitoring receptor mediated regulation of cytosolic calcium in single pituitary cells by dual excitation microfluorimetry. J Recept Res 1988 0.93
125 Transient expression of botulinum neurotoxin C1 light chain differentially inhibits calcium and glucose induced insulin secretion in clonal beta-cells. FEBS Lett 1997 0.93
126 Stimulus-response coupling in insulin-secreting HIT cells. Effects of secretagogues on cytosolic Ca2+, diacylglycerol, and protein kinase C activity. J Biol Chem 1990 0.93
127 Glyceraldehyde, but not cyclic AMP-stimulated insulin release is preceded by a rise in cytosolic free Ca2+. FEBS Lett 1984 0.93
128 Inositol tetrakisphosphate isomers and elevation of cytosolic Ca2+ in vasopressin-stimulated insulin-secreting RINm5F cells. J Biol Chem 1992 0.93
129 Establishment of rat pancreatic endocrine cell lines by infection with simian virus 40. Biochem J 1979 0.93
130 Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger. J Cell Sci 1999 0.92
131 Extracellular ATP causes Ca2(+)-dependent and -independent insulin secretion in RINm5F cells. Phospholipase C mediates Ca2+ mobilization but not Ca2+ influx and membrane depolarization. J Biol Chem 1991 0.92
132 Regulation of Ca2+ transport by isolated organelles of a rat insulinoma. Studies with endoplasmic reticulum and secretory granules. J Biol Chem 1984 0.92
133 Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta. Biochem Biophys Res Commun 1999 0.91
134 Measurement of cytosolic free Ca2+ in individual pancreatic acini. FEBS Lett 1988 0.91
135 A natural interleukin 1 (IL-1) inhibitor counteracts the inhibitory effect of IL-1 on insulin production in cultured rat pancreatic islets. J Autoimmun 1989 0.91
136 Intracellular pattern of cytosolic Ca2+ changes during adhesion and multiple phagocytosis in human neutrophils. Dynamics of intracellular Ca2+ stores. Blood 1995 0.91
137 Defective calcium handling and insulin release in islets from diabetic Chinese hamsters. Biochem J 1979 0.90
138 Pertussis toxin selectively abolishes hormone induced lowering of cytosolic calcium in GH3 cells. FEBS Lett 1985 0.90
139 Synergistic activation of NF-kappab and inducible isoform of nitric oxide synthase induction by interferon-gamma and tumor necrosis factor-alpha in INS-1 cells. J Cell Physiol 2000 0.90
140 von Willebrand factor (vWf) as a plasma marker of endothelial activation in diabetes: improved reliability with parallel determination of the vWf propeptide (vWf:AgII). Thromb Haemost 1998 0.90
141 Somatostatin lowers the cytosolic free Ca2+ concentration in clonal rat pituitary cells (GH3 cells). Cell Calcium 1984 0.90
142 Mode of activation of bovine brain inositol 1,4,5-trisphosphate 3-kinase by calmodulin and calcium. Biochem J 1989 0.90
143 Single cell monitoring of cytosolic calcium reveals subtypes of rat lactotrophs with distinct responses to dopamine and thyrotropin-releasing hormone. Endocrinology 1987 0.89
144 The role of extracellular Ca++ and islet calcium stores in the regulation of biphasic insulin release. Horm Metab Res Suppl 1980 0.89
145 Possible role for mitochondrial calcium in angiotensin II- and potassium-stimulated steroidogenesis in bovine adrenal glomerulosa cells. Endocrinology 1996 0.89
146 Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. Br J Pharmacol 2009 0.89
147 Voltage dependent calcium channels in adrenal glomerulosa cells and in insulin producing cells. Cell Calcium 1998 0.89
148 omega-Conotoxin-sensitive, voltage-operated Ca2+ channels in insulin-secreting cells. Eur J Pharmacol 1992 0.89
149 Evidence for the involvement of Na/Ca exchange in glucose-induced insulin release from rat pancreatic islets. J Clin Invest 1980 0.88
150 Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells. Eur J Biochem 1992 0.88
151 Alpha, beta I, beta II, delta, and epsilon protein kinase C isoforms and compound activity in the sciatic nerve of normal and diabetic rats. J Neurochem 1994 0.86
152 Expression of alpha-1 proteinase inhibitor in human islet microvascular endothelial cells. Diabetes 1999 0.86
153 Mitochondrial calcium oscillations in C2C12 myotubes. J Biol Chem 2000 0.85
154 Dependency of acetylcholine-induced insulin release on Ca++ uptake by rat pancreatic islets. Endocrinology 1980 0.85
155 In vivo phosphorylation of the Na,K-ATPase alpha subunit in sciatic nerves of control and diabetic rats: effects of protein kinase modulators. Proc Natl Acad Sci U S A 1994 0.85
156 Biphasic insulin release in rat islets of Langerhans and the role of Intracellular Ca++ stores. Endocrinology 1979 0.85
157 Conserved transducer coupling but different effector linkage upon expression of the myeloid fMet-Leu-Phe receptor in insulin secreting cells. EMBO J 1993 0.84
158 Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix. Diabetes 2001 0.84
159 Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell. Biofactors 1998 0.84
160 Effect of insulin on glucose- and arginine-stimulated somatostatin secretion from the isolated perfused rat pancreas. Endocrinology 1981 0.84
161 Inhibition of insulin release by somatostatin: no evidence for interaction with calcium. Metabolism 1978 0.83
162 Somatostatin inhibition of pancreatic glucagon release from monolayer cultures and interactions with calcium. Endocrinology 1977 0.83
163 Characterization of alpha 2-adrenoceptors in a plasma membrane enriched fraction from the insulin-secreting cell line RINm5F. Acta Endocrinol (Copenh) 1989 0.82
164 Involvement of Ca2+ in the impaired glucose-induced insulin release from islets cultured at low glucose. Diabetes 1983 0.82
165 Effect of 2-mercaptoethanol on glutathione levels, cystine uptake and insulin secretion in insulin-secreting cells. Eur J Biochem 1992 0.82
166 Sites of action of trifluoperazine in the inhibition of glucose-stimulated insulin release. Diabetes 1981 0.82
167 Expression of both alpha 1- and alpha 2-adrenoceptors in an insulin-secreting cell line. Parallel studies of cytosolic free Ca2+ and insulin release. Mol Pharmacol 1985 0.82
168 Autocrine regulation of endothelial exocytosis: von Willebrand factor release is induced by prostacyclin in cultured endothelial cells. FEBS Lett 1998 0.81
169 Characterization of two distinct liver progenitor cell subpopulations of hematopoietic and hepatic origins. Exp Cell Res 2006 0.81
170 Glucose-induced first phase insulin release in the absence of extracellular Ca2+ in rat islets. FEBS Lett 1980 0.81
171 Characterization of glucose transport in an insulin-secreting cell line. Biochem J 1987 0.81
172 Effect of a new hypoglycaemic agent (HB 699) on the in vivo secretion of pancreatic hormones in the dog. Diabetologia 1981 0.81
173 Coordinated regulation of free Ca2+ by isolated organelles from a rat insulinoma. J Biol Chem 1984 0.80
174 Oscillations of cytosolic free calcium in bombesin-stimulated HIT-T15 cells. Cell Calcium 1996 0.80
175 Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1. Endocrinology 1996 0.79
176 What couples glycolysis to mitochondrial signal generation in glucose-stimulated insulin secretion? IUBMB Life 2000 0.79
177 Cobalt inhibition of insulin release: evidence for an action not related to Ca2+ uptake. Am J Physiol 1984 0.79
178 Modulation of glutamate generation in mitochondria affects hormone secretion in INS-1E beta cells. IUBMB Life 2000 0.79
179 Calcium mobilization by inositol 1,4,5-trisphosphate during activation of islet, pituitary, and myeloid cells. J Cardiovasc Pharmacol 1986 0.79
180 Glucose-induced insulin secretion in INS-1 cells depends on factors present in fetal calf serum and rat islet-conditioned medium. Diabetes 1997 0.79
181 Insulin release during fasting: studies on adenylate cyclase, phosphodiesterase, protein kinase, and phosphoprotein phosphatase in isolated islets of langerhans of the rat. Endocrinology 1979 0.79
182 GH signalling in pancreatic beta-cells. Endocr J 1998 0.79
183 Rapid changes in calcium content of rat pancreatic islets in response to glucose. Diabetes 1981 0.79
184 Effect of cholera toxin on insulin release in monolayer cultures of the endocrine pancreas. Diabetologia 1974 0.79
185 Potentiation of stimulus-induced insulin secretion in protein kinase C-deficient RINm5F cells. Biochem J 1990 0.79
186 Role of Ca2+ in impaired insulin release from islets of diabetic (C57BL/KsJ-db/db) mice. Am J Physiol 1980 0.78
187 Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets. Genes Immun 2007 0.78
188 Establishment and culture of insulin-secreting beta cell lines. Methods Enzymol 1990 0.78
189 In vivo stimulation of pancreatic hormone secretion by norepinephrine infusion in the dog. Am J Physiol 1984 0.78
190 Calcium induced glucagon release in monolayer culture of the endocrine pancreas. Studies with ionophore A23187. Diabetologia 1976 0.78
191 Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats. Metabolism 1993 0.78
192 Selective inhibition of glucose-stimulated insulin release by dantrolene. Am J Physiol 1982 0.78
193 Interactions of Ca2+, Mg2+, and Na+ in regulation of insulin release from rat islets. Am J Physiol 1983 0.78
194 Taspoglutide, a novel human once-weekly GLP-1 analogue, protects pancreatic β-cells in vitro and preserves islet structure and function in the Zucker diabetic fatty rat in vivo. Diabetes Obes Metab 2011 0.78
195 Glucose and cyclic AMP as stimulators of somatostatin and insulin secretion from the isolated, perfused rat pancreas: a quantitative study. Diabetes 1981 0.78
196 Calcium signalling: comparison of the role of Ca2+ influx in excitable endocrine and non-excitable myeloid cells. Adv Second Messenger Phosphoprotein Res 1993 0.77
197 Stimulation of insulin release by glucose in a transplantable rat islet cell tumor. Endocrinology 1982 0.77
198 Importance of cellular calcium stores in glucose-stimulated insulin release. Ups J Med Sci 1981 0.76
199 Caerulein causes translocation of protein kinase C in rat acini without increasing cytosolic free Ca2+. Am J Physiol 1988 0.76
200 The stimulatory effect of rabphilin 3a on regulated exocytosis from insulin-secreting cells does not require an association-dissociation cycle with membranes mediated by Rab 3. Eur J Cell Biol 1997 0.76
201 Regulation of cytosolic calcium and insulin secretion by galanin and ATP receptors: interactions of pertussis-toxin-sensitive and -insensitive signalling pathways. Biochem J 1994 0.76
202 Diacylglycerol as messenger. Nature 1990 0.75
203 Improved insulin secretion of cryopreserved human islets by antioxidant treatment. Pancreas 1996 0.75
204 Defect in the excretion of a vasoactive polypeptide fraction A possible genetic marker of primary hypertension. Hypertension 1982 0.75
205 Calmodulin in various insulin secreting cell types. J Endocrinol Invest 1985 0.75
206 Beneficial effects of low-carbohydrate--high-protein diets in long-term diabetic rats. Metabolism 1980 0.75
207 Phenytoin inhibition of insulin release. Studies on the involvement of Ca2+ fluxes in rat pancreatic islets. Diabetes 1982 0.75
208 Sodium requirement for insulin release: putative role in regulation of intracellular pH. Am J Physiol 1986 0.75
209 Studies in vivo and in vitro on chemically-induced primary islet cell tumours and non-tumour endocrine pancreatic tissue. Diabetologia 1983 0.75
210 Stimulatory and inhibitory effects of cyclic AMP on pancreatic glucagon release from monolayer cultures and the controlling role of calcium. Diabetologia 1976 0.75
211 Plasma growth hormone, insulin, and glucagon responses to arginine infusion in children and adolescents with idiopathic short stature, isolated growth hormone deficiency, panhypopituitarism, and anorexia nervosa. Pediatr Res 1975 0.75
212 Regulated von Willebrand factor (vWf) secretion is restored by pro-vWf expression in a transfectable endothelial cell line. Biochim Biophys Acta 2000 0.75
213 Energy dispersive X-ray microanalysis of zinc and calcium in organelles of insulin-producing cells of the mouse, rat, and a fish. Biomed Biochim Acta 1985 0.75
214 Enhancement of insulin release and islet cell calcium content by an acyl-amino-alkyl benzoic acid derivative, HB 699. Horm Metab Res 1985 0.75
215 Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor. Ann Nutr Metab 1993 0.75
216 Prenylcysteine analogs mimicking the C-terminus of GTP-binding proteins stimulate exocytosis from permeabilized HIT-T15 cells: comparison with the effect of Rab3AL peptide. Biochim Biophys Acta 1995 0.75
217 Albert E. Renold: July 10, 1923-March 21, 1988. Diabetologia 1988 0.75
218 [Pathways of insulin secretion: the role of calcium and other intracellular messengers]. Journ Annu Diabetol Hotel Dieu 1989 0.75
219 Defective Ca++ handling and insulin release in islets of diabetic hamsters and mice. Acta Biol Med Ger 1981 0.75
220 Comparison of insulin secretion by the isolated perfused pancreas and perifused islets of the spiny mouse (Acomys cahirinus). Acta Biol Med Ger 1981 0.75
221 Streptozotocin-induced functioning islet cell tumor in the rat: high frequency of induction and biological properties of the tumor cells. Toxicol Pathol 1984 0.75
222 Inverse relationship between glucose metabolism and glucose-induced insulin secretion in rat insulinoma cells. Horm Res 1990 0.75
223 In vitro and in vivo studies on glucagonoma tissue. Horm Metab Res 1980 0.75
224 Perturbation of hormone storage and release induced by cyproheptadine in rat pancreatic islets in vitro. Endocrinology 1979 0.75
225 Rapid 'on-line' image processing as a tool in the evaluation of kinetic and morphological aspects of receptor-induced cell activation. J Recept Res 1991 0.75
226 Islet isolation from slaughterhouse pig pancreata: evidence of in vitro and in vivo function. Transplant Proc 1994 0.75
227 Restoration of glucose-induced insulin release in the absence of extracellular calcium by inhibition of the Na+-pump. FEBS Lett 1980 0.75
228 Role of the intestinal acyl-CoA:cholesterol acyltransferase activity in the hyperresponse of diabetic rats to dietary cholesterol. J Lipid Res 1992 0.75
229 Stimulation of pancreatic polypeptide secretion in the dog by hypoglycemic agent HB 699. Am J Physiol 1983 0.75
230 Islets of Langerhans autotransplantation in humans. Transplant Proc 1994 0.75