Published in Sci Rep on April 05, 2017
TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature (1997) 15.75
Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest (2003) 12.56
Evidence that fibroblasts derive from epithelium during tissue fibrosis. J Clin Invest (2002) 12.22
How cells read TGF-beta signals. Nat Rev Mol Cell Biol (2000) 8.93
Smads: transcriptional activators of TGF-beta responses. Cell (1998) 5.33
NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest (2004) 5.06
Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest (2003) 4.58
Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol (2001) 4.39
New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83
Tubulointerstitial changes as a major determinant in the progression of renal damage. Am J Kidney Dis (1992) 3.73
Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol (2002) 3.44
Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation. Kidney Int (2002) 3.16
Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol (1996) 2.97
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J (2006) 2.80
The progression of renal disease. N Engl J Med (1988) 2.70
Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Pathol (2005) 2.38
Transforming growth factor-beta and Smad signalling in kidney diseases. Nephrology (Carlton) (2005) 2.23
Renal fibrosis: collagen composition and assembly regulates epithelial-mesenchymal transdifferentiation. Am J Pathol (2001) 2.18
Obstructive nephropathy: insights from genetically engineered animals. Kidney Int (2005) 1.97
Mechanisms of tubulointerstitial fibrosis. Curr Opin Nephrol Hypertens (2004) 1.92
Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J (2006) 1.59
Obstructive nephropathy: towards biomarker discovery and gene therapy. Nat Clin Pract Nephrol (2006) 1.58
The role of tubular epithelial-mesenchymal transition in progressive kidney disease. Cells Tissues Organs (2007) 1.46
Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury. Histol Histopathol (2002) 1.34
Hepatocyte growth factor suppresses interstitial fibrosis in a mouse model of obstructive nephropathy. Kidney Int (2001) 1.25
Macrophages, monocyte chemoattractant peptide-1, and TGF-beta 1 in experimental hydronephrosis. Am J Physiol (1994) 1.24
Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney. J Histochem Cytochem (2007) 1.17
Mice lacking the matrix metalloproteinase-9 gene reduce renal interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2010) 1.12
Cell apoptosis and proliferation in experimental chronic obstructive uropathy. Kidney Int (1996) 1.07
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage. Toxicology (2007) 1.06
Obstructive nephropathy and renal fibrosis: The role of bone morphogenic protein-7 and hepatocyte growth factor. Kidney Int Suppl (2003) 1.06
Osteopontin regulates renal apoptosis and interstitial fibrosis in neonatal chronic unilateral ureteral obstruction. Kidney Int (2006) 1.03
Lipoic acid as a novel treatment for Alzheimer's disease and related dementias. Pharmacol Ther (2006) 1.01
A reduction of unilateral ureteral obstruction-induced renal fibrosis by a therapy combining valsartan with aliskiren. Am J Physiol Renal Physiol (2010) 1.00
Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity. Exp Mol Med (2007) 0.97
Cytokines in kidney disease: the role of transforming growth factor-beta. Am J Kidney Dis (1993) 0.94
Interstitial fibrosis in obstructive nephropathy. Kidney Int (1993) 0.89
Physiological and histopathological investigations on the effects of alpha-lipoic acid in rats exposed to malathion. J Biomed Biotechnol (2010) 0.87
Treatment of chronic tubulointerstitial disease: a new concept. Kidney Int (2002) 0.85
Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity. Int Immunopharmacol (2007) 0.83
Ulinastatin inhibits unilateral ureteral obstruction-induced renal interstitial fibrosis in rats via transforming growth factor β (TGF-β)/Smad signalling pathways. Int Immunopharmacol (2013) 0.82
The pathophysiology of obstructive nephropathy: the role of vasoactive compounds in the hemodynamic and structural abnormalities of the obstructed kidney. Am J Kidney Dis (1994) 0.81
Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats. Nephron Exp Nephrol (2009) 0.80
Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats. PLoS One (2015) 0.79
Protective effect of alpha-lipoic acid against ischaemic acute renal failure in rats. Clin Exp Pharmacol Physiol (2002) 0.79
Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice. Toxicon (2010) 0.78
Upregulation of Interleukin-33 in obstructive renal injury. Biochem Biophys Res Commun (2016) 0.77
IGF-1 protects tubular epithelial cells during injury via activation of ERK/MAPK signaling pathway. Sci Rep (2016) 0.76
Alpha lipoic acid attenuates radiation-induced thyroid injury in rats. PLoS One (2014) 1.40
Glutamine protects against cisplatin-induced nephrotoxicity by decreasing cisplatin accumulation. J Pharmacol Sci (2014) 0.79
Protective effects of alpha lipoic acid on radiation-induced salivary gland injury in rats. Oncotarget (2016) 0.75
Alpha lipoic acid attenuates radiation-induced oral mucositis in rats. Oncotarget (2017) 0.75