Conditional ablation of macrophages halts progression of crescentic glomerulonephritis.

PubWeight™: 2.38‹?› | Rank: Top 2%

🔗 View Article (PMC 1603796)

Published in Am J Pathol on November 01, 2005

Authors

Jeremy S Duffield1, Peter G Tipping, Tiina Kipari, Jean-François Cailhier, Spike Clay, Richard Lang, Joseph V Bonventre, Jeremy Hughes

Author Affiliations

1: Medical Research Council Centre for Inflammation Research Medical School, University of Edinburgh, UK, and the Renal Division, Brigham & Women's Hospital, Boston, MA 02115, USA. jduffield@rics.bwh.harvard.edu

Articles citing this

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34

Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol (2008) 5.06

Macrophage diversity in renal injury and repair. J Clin Invest (2008) 4.41

A distinct macrophage population mediates metastatic breast cancer cell extravasation, establishment and growth. PLoS One (2009) 3.86

Macrophage Wnt7b is critical for kidney repair and regeneration. Proc Natl Acad Sci U S A (2010) 2.87

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol (2008) 2.83

Macrophage roles following myocardial infarction. Int J Cardiol (2008) 2.14

Targeting endothelium-pericyte cross talk by inhibiting VEGF receptor signaling attenuates kidney microvascular rarefaction and fibrosis. Am J Pathol (2011) 2.12

Host responses in tissue repair and fibrosis. Annu Rev Pathol (2012) 2.10

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01

Studying the mononuclear phagocyte system in the molecular age. Nat Rev Immunol (2011) 1.93

Serum amyloid P inhibits fibrosis through Fc gamma R-dependent monocyte-macrophage regulation in vivo. Sci Transl Med (2009) 1.74

Macrophages and immunologic inflammation of the kidney. Semin Nephrol (2010) 1.71

Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation (2009) 1.56

Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases. Immunity (2008) 1.47

Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol (2007) 1.39

Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol (2008) 1.38

Decreased Expression of Connexin 43 Blunts the Progression of Experimental GN. J Am Soc Nephrol (2017) 1.38

Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet (2008) 1.31

Multiphoton imaging reveals a new leukocyte recruitment paradigm in the glomerulus. Nat Med (2012) 1.23

Scope and mechanisms of obesity-related renal disease. Curr Opin Nephrol Hypertens (2010) 1.20

Macrophage matrix metalloproteinase-9 mediates epithelial-mesenchymal transition in vitro in murine renal tubular cells. Am J Pathol (2010) 1.17

CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD. J Am Soc Nephrol (2009) 1.15

Anti-proteinase 3 anti-neutrophil cytoplasm autoantibodies recapitulate systemic vasculitis in mice with a humanized immune system. PLoS One (2012) 1.12

Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium. Am J Physiol Renal Physiol (2009) 1.12

By homing to the kidney, activated macrophages potently exacerbate renal injury. Am J Pathol (2008) 1.11

Bidirectional microglia-neuron communication in the healthy brain. Neural Plast (2013) 1.09

The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J (2010) 1.09

Role of T cells and dendritic cells in glomerular immunopathology. Semin Immunopathol (2007) 1.08

Macrophages expressing heme oxygenase-1 improve renal function in ischemia/reperfusion injury. Mol Ther (2010) 1.08

The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. J Hepatol (2011) 1.04

Regulation of wound healing and organ fibrosis by toll-like receptors. Biochim Biophys Acta (2012) 0.99

Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis. Am J Pathol (2006) 0.99

Lupus nephritis: current update. Arthritis Res Ther (2011) 0.97

Macrophages regulate corpus luteum development during embryo implantation in mice. J Clin Invest (2013) 0.92

Blockade of the kinin B1 receptor ameloriates glomerulonephritis. J Am Soc Nephrol (2010) 0.91

Inhibition of indoleamine 2, 3-dioxygenase-mediated tryptophan catabolism accelerates crescentic glomerulonephritis. Clin Exp Immunol (2009) 0.91

Macrophages in vascular inflammation--From atherosclerosis to vasculitis. Autoimmunity (2015) 0.91

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis. Am J Pathol (2010) 0.90

Serum-starved adipose-derived stromal cells ameliorate crescentic GN by promoting immunoregulatory macrophages. J Am Soc Nephrol (2013) 0.89

Osthole mitigates progressive IgA nephropathy by inhibiting reactive oxygen species generation and NF-κB/NLRP3 pathway. PLoS One (2013) 0.89

Impact of macrophage deficiency and depletion on continuous glucose monitoring in vivo. Biomaterials (2013) 0.89

Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am J Pathol (2008) 0.89

Conditional ablation of macrophages disrupts ovarian vasculature. Reproduction (2011) 0.87

Epithelial-mesenchymal transition: An emerging target in tissue fibrosis. Exp Biol Med (Maywood) (2015) 0.86

Dendritic cells and macrophages in the kidney: a spectrum of good and evil. Nat Rev Nephrol (2014) 0.86

Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis. Immunology (2009) 0.86

Neutrophils: game changers in glomerulonephritis? Trends Mol Med (2010) 0.86

Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice. Am J Pathol (2011) 0.86

Mannose receptor interacts with Fc receptors and is critical for the development of crescentic glomerulonephritis in mice. J Clin Invest (2010) 0.85

Association of superoxide anions with retinal pigment epithelial cell apoptosis induced by mononuclear phagocytes. Invest Ophthalmol Vis Sci (2009) 0.85

Dendritic cells and macrophages in kidney disease. Clin Exp Nephrol (2009) 0.84

Deletion of scavenger receptor A protects mice from progressive nephropathy independent of lipid control during diet-induced hyperlipidemia. Kidney Int (2012) 0.83

Macrophage Phenotype in Kidney Injury and Repair. Kidney Dis (Basel) (2015) 0.82

Update on crescentic glomerulonephritis. Semin Immunopathol (2014) 0.82

Sisters in arms: myeloid and tubular epithelial cells shape renal innate immunity. Am J Physiol Renal Physiol (2013) 0.81

Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokines. Am J Pathol (2009) 0.81

Tim3 is upregulated and protective in nephrotoxic serum nephritis. Am J Pathol (2010) 0.81

Collagen XIII induced in vascular endothelium mediates alpha1beta1 integrin-dependent transmigration of monocytes in renal fibrosis. Am J Pathol (2010) 0.81

The Debate about Dendritic Cells and Macrophages in the Kidney. Front Immunol (2015) 0.80

Absence of nicotinic acetylcholine receptor α7 subunit amplifies inflammation and accelerates onset of fibrosis: an inflammatory kidney model. FASEB J (2015) 0.79

Selective CCR2-targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis. Clin Exp Immunol (2008) 0.79

Microglia-Neuron Communication in Epilepsy. Glia (2016) 0.78

Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors. Am J Physiol Renal Physiol (2014) 0.78

Mechanisms of immunity in post-exposure vaccination against Ebola virus infection. PLoS One (2015) 0.78

Lutheran/basal cell adhesion molecule accelerates progression of crescentic glomerulonephritis in mice. Kidney Int (2014) 0.78

The macrophage phagocytic receptor CD36 promotes fibrogenic pathways on removal of apoptotic cells during chronic kidney injury. Am J Pathol (2015) 0.78

Liraglutide Reduces Both Atherosclerosis and Kidney Inflammation in Moderately Uremic LDLr-/- Mice. PLoS One (2016) 0.77

Transfer of antigen from human B cells to dendritic cells. Mol Immunol (2013) 0.77

Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis. PLoS One (2016) 0.76

S100A8/A9 (calprotectin) is critical for development of glomerulonephritis and promotes inflammatory leukocyte-renal cell interactions. Am J Pathol (2015) 0.75

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis. Cell Death Dis (2016) 0.75

The Small Tellurium Compound AS101 Ameliorates Rat Crescentic Glomerulonephritis: Association with Inhibition of Macrophage Caspase-1 Activity via Very Late Antigen-4 Inactivation. Front Immunol (2017) 0.75

Following specific podocyte injury captopril protects against progressive long term renal damage. F1000Res (2015) 0.75

Macrophage A2A Adenosine Receptors Are Essential to Protect from Progressive Kidney Injury. Am J Pathol (2016) 0.75

Infiltrating CD16(+) Are Associated with a Reduction in Peripheral CD14(+)CD16(++) Monocytes and Severe Forms of Lupus Nephritis. Autoimmune Dis (2016) 0.75

Crucial Role of Mesangial Cell-derived Connective Tissue Growth Factor in a Mouse Model of Anti-Glomerular Basement Membrane Glomerulonephritis. Sci Rep (2017) 0.75

Loss of endogenous thymosin β4 accelerates glomerular disease. Kidney Int (2016) 0.75

Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice. Sci Rep (2017) 0.75

Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis. F1000Res (2017) 0.75

Articles cited by this

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum. Am J Pathol (1975) 6.42

Other functions, other genes: alternative activation of antigen-presenting cells. Immunity (1999) 4.15

Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science (1990) 3.27

Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol (2001) 3.13

Phagocytosis promotes programmed cell death in C. elegans. Nature (2001) 3.12

Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem (2002) 2.88

Wound healing in the PU.1 null mouse--tissue repair is not dependent on inflammatory cells. Curr Biol (2003) 2.87

The liposome-mediated macrophage 'suicide' technique. J Immunol Methods (1989) 2.73

Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature (2001) 2.64

Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J Immunol (2005) 2.50

The inflammatory macrophage: a story of Jekyll and Hyde. Clin Sci (Lond) (2003) 2.49

Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J Immunol (1999) 2.43

Prognostic factors in lupus nephritis. Contribution of renal histologic data. Am J Med (1983) 2.38

Influence of alternatively and classically activated macrophages on fibrogenic activities of human fibroblasts. Cell Immunol (2000) 2.18

Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. Circulation (2002) 2.01

A new morphologic index for the evaluation of renal biopsies in lupus nephritis. Kidney Int (2000) 2.01

Macrophages induce apoptosis in normal cells in vivo. Development (1997) 1.94

Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas(lpr) mice. J Exp Med (1999) 1.94

Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J Clin Invest (1999) 1.84

Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest (1994) 1.83

Selectins mediate macrophage infiltration in obstructive nephropathy in newborn mice. Kidney Int (2002) 1.72

Apoptosis during macrophage-dependent ocular tissue remodelling. Development (1994) 1.68

Obstructive uropathy in the mouse: role of osteopontin in interstitial fibrosis and apoptosis. Kidney Int (1999) 1.60

Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis. Kidney Int (2003) 1.60

Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. J Biol Chem (2004) 1.59

Crescentic glomerulonephritis in CD4- and CD8-deficient mice. Requirement for CD4 but not CD8 cells. Am J Pathol (1998) 1.44

Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. J Biol Chem (2001) 1.43

Mammalian G1 and G2 phase checkpoints. Cancer Surv (1997) 1.41

Macrophages kill capillary cells in G1 phase of the cell cycle during programmed vascular regression. Development (1999) 1.40

Activated macrophages direct apoptosis and suppress mitosis of mesangial cells. J Immunol (2000) 1.34

Macrophages act as effectors of tissue damage in acute renal allograft rejection. Transplantation (2003) 1.32

Macrophage-induced glomerular fibrin deposition in experimental glomerulonephritis in the rabbit. J Clin Invest (1985) 1.31

Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation. Kidney Int (2003) 1.30

Local macrophage proliferation in human glomerulonephritis. Kidney Int (1998) 1.26

Mechanisms of T cell-induced glomerular injury in anti-glomerular basement membrane (GBM) glomerulonephritis in rats. Clin Exp Immunol (1997) 1.25

Kupffer cell depletion by gadolinium chloride enhances liver regeneration after partial hepatectomy in rats. Am J Physiol (1996) 1.25

The complex role of interleukin-10 in autoimmunity. J Autoimmun (2003) 1.19

Glomerular epithelial-mesenchymal transdifferentiation in pauci-immune crescentic glomerulonephritis. Nephrol Dial Transplant (2003) 1.18

Reduced macrophage recruitment, proliferation, and activation in colony-stimulating factor-1-deficient mice results in decreased tubular apoptosis during renal inflammation. J Immunol (2003) 1.18

Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice. J Am Soc Nephrol (2004) 1.15

Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4. J Immunol (2000) 1.15

Sublethal X-irradiation during acute puromycin nephrosis prevents late renal injury: role of macrophages. Am J Physiol (1991) 1.13

Decreased PMN accumulation and glomerular damage by clodronate liposome treatment in PMN-dependent anti-GBM nephritis in mice. Exp Nephrol (1997) 1.10

Quantitative morphometry of lupus nephritis: the significance of collagen, tubular space, and inflammatory infiltrate. Kidney Int (2005) 1.05

Suppression by apoptotic cells defines tumor necrosis factor-mediated induction of glomerular mesangial cell apoptosis by activated macrophages. Am J Pathol (2001) 1.05

Cell biology. Eat me or die. Science (2003) 1.02

IFN-gamma production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice. J Immunol (2002) 1.02

Macrophages induce apoptosis in proximal tubule cells. Pediatr Nephrol (2003) 1.01

Local macrophage proliferation in the progression of glomerular and tubulointerstitial injury in rat anti-GBM glomerulonephritis. Kidney Int (1995) 1.01

Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases. Am J Nephrol (2000) 1.00

Cellular composition of crescents in human rapidly progressive glomerulonephritis identified using monoclonal antibodies. Am J Nephrol (1984) 0.98

Phagocytosis of apoptotic cells in mammals, caenorhabditis elegans and Drosophila melanogaster: molecular mechanisms and physiological consequences. Front Biosci (2002) 0.96

Heterogeneity of antigen expression explains controversy over glomerular macrophage accumulation in mouse glomerulonephritis. Nephrol Dial Transplant (2003) 0.96

Microvascular and tubulointerstitial injury associated with chronic hypoxia-induced hypertension. Kidney Int (2003) 0.93

Unilateral ureteral obstruction induces renal tubular cell production of tumor necrosis factor-alpha independent of inflammatory cell infiltration. J Urol (2004) 0.90

TGF-beta1 as an endogenous defender against macrophage-triggered stromelysin gene expression in the glomerulus. J Immunol (1998) 0.83

Glomerular macrophages and the mesangial proliferative response in the experimental nephrotic syndrome. Am J Pathol (1992) 0.83

Articles by these authors

Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol (2005) 18.76

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int (2002) 8.03

Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis. Am J Pathol (2009) 7.34

Intrinsic epithelial cells repair the kidney after injury. Cell Stem Cell (2008) 6.54

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med (2010) 4.76

Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest (2005) 4.10

Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol (2005) 3.94

Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate. Kidney Int (2010) 3.78

Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am J Physiol Renal Physiol (2003) 3.61

Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest (2008) 3.59

Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol (2007) 3.48

Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. JAMA (2004) 3.34

Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol (2008) 3.10

Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol (2010) 3.07

Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int (2011) 3.05

Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol (2010) 3.03

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis. J Clin Invest (2013) 3.03

Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci (2008) 2.98

Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol (2009) 2.96

Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol (2008) 2.83

Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol (2006) 2.75

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis. Kidney Int (2012) 2.74

Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ Res (2007) 2.74

Conditional macrophage ablation demonstrates that resident macrophages initiate acute peritoneal inflammation. J Immunol (2005) 2.50

Acute renal failure in zebrafish: a novel system to study a complex disease. Am J Physiol Renal Physiol (2004) 2.50

A rapid urine test for early detection of kidney injury. Kidney Int (2009) 2.50

Kidney tubular epithelium is restored without replacement with bone marrow-derived cells during repair after ischemic injury. Kidney Int (2005) 2.43

Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration. J Biol Chem (2002) 2.36

Mesenchymal stem cells in acute kidney injury. Annu Rev Med (2008) 2.33

Repair of injured proximal tubule does not involve specialized progenitors. Proc Natl Acad Sci U S A (2011) 2.22

The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol (2003) 2.20

Kidney injury molecule-1 (KIM-1): a urinary biomarker and much more. Nephrol Dial Transplant (2009) 2.12

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease. Nat Neurosci (2008) 2.09

Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis (2008) 2.05

High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation (2007) 2.01

Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury. J Biol Chem (2004) 1.96

Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci (2007) 1.94

Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet (2009) 1.94

Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int (2009) 1.94

Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice. Kidney Int (2012) 1.92

Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Development (2002) 1.91

Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation. Development (2012) 1.89

Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol (2006) 1.85

The renal mononuclear phagocytic system. J Am Soc Nephrol (2011) 1.84

Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. Am J Respir Crit Care Med (2012) 1.82

KIM-1-mediated phagocytosis reduces acute injury to the kidney. J Clin Invest (2015) 1.80

Imperfect gold standards for kidney injury biomarker evaluation. J Am Soc Nephrol (2011) 1.79

Protection of renal epithelial cells against oxidative injury by endoplasmic reticulum stress preconditioning is mediated by ERK1/2 activation. J Biol Chem (2003) 1.78

Comparative analysis of urinary biomarkers for early detection of acute kidney injury following cardiopulmonary bypass. Biomarkers (2009) 1.77

Biologic markers for the early detection of acute kidney injury. Curr Opin Crit Care (2004) 1.75

Release of free F2-isoprostanes from esterified phospholipids is catalyzed by intracellular and plasma platelet-activating factor acetylhydrolases. J Biol Chem (2005) 1.73

Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma. J Am Soc Nephrol (2005) 1.71

Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. Kidney Int (2012) 1.69

Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells. PLoS One (2009) 1.69

Osteopontin is a critical inhibitor of calcium oxalate crystal formation and retention in renal tubules. J Am Soc Nephrol (2003) 1.68

Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase. Kidney Int (2010) 1.67

Kidney injury molecule-1 expression in murine polycystic kidney disease. Am J Physiol Renal Physiol (2002) 1.64

Inducible nitric-oxide synthase is an important contributor to prolonged protective effects of ischemic preconditioning in the mouse kidney. J Biol Chem (2003) 1.63

Rapid screening of glomerular slit diaphragm integrity in larval zebrafish. Am J Physiol Renal Physiol (2007) 1.63

Pathophysiology of acute kidney injury to chronic kidney disease: maladaptive repair. Contrib Nephrol (2011) 1.57

Biomarkers of nephrotoxic acute kidney injury. Toxicology (2008) 1.55

Some biomarkers of acute kidney injury are increased in pre-renal acute injury. Kidney Int (2012) 1.55

Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. Toxicol Pathol (2008) 1.51

T cell, Ig domain, mucin domain-2 gene-deficient mice reveal a novel mechanism for the regulation of Th2 immune responses and airway inflammation. J Immunol (2006) 1.51

Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart (2010) 1.50

Effects of cyclosporine in osteopontin null mice. Kidney Int (2002) 1.47

Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol (2006) 1.47

NADPH oxidase p22phox and catalase gene variants are associated with biomarkers of oxidative stress and adverse outcomes in acute renal failure. J Am Soc Nephrol (2006) 1.46

Urinary expression of novel tissue markers of kidney injury after ureteroscopy, shockwave lithotripsy, and in normal healthy controls. J Endourol (2013) 1.46

Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Crit Care Med (2008) 1.44

Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral obstruction. J Biol Chem (2001) 1.43

Peritoneal and pericardial communication after cardiac surgery with delayed clinical manifestations. Perit Dial Int (2002) 1.40

Creatinine as the gold standard for kidney injury biomarker studies? Nephrol Dial Transplant (2009) 1.39

Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol (2006) 1.36

Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A (2012) 1.35

Test characteristics of urinary biomarkers depend on quantitation method in acute kidney injury. J Am Soc Nephrol (2011) 1.35

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener (2012) 1.34

Systemic microvascular leak in an in vivo rat model of ventilator-induced lung injury. Am J Respir Crit Care Med (2003) 1.32

The Sweet Pee model for Sglt2 mutation. J Am Soc Nephrol (2011) 1.32

A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9. Biochem Biophys Res Commun (2006) 1.29

HIF in kidney disease and development. J Am Soc Nephrol (2008) 1.28

Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther (2008) 1.28

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem (2004) 1.28

Local amplification of glucocorticoids by 11 beta-hydroxysteroid dehydrogenase type 1 promotes macrophage phagocytosis of apoptotic leukocytes. J Immunol (2006) 1.27

A framework and key research questions in AKI diagnosis and staging in different environments. Clin J Am Soc Nephrol (2008) 1.27

Associations of urinary levels of kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) with kidney function decline in the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis (2012) 1.27

Orchiectomy attenuates post-ischemic oxidative stress and ischemia/reperfusion injury in mice. A role for manganese superoxide dismutase. J Biol Chem (2006) 1.25

Deletion of secretory group V phospholipase A2 attenuates cell migration and airway hyperresponsiveness in immunosensitized mice. J Immunol (2007) 1.25

Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol (2006) 1.24

Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases. Am J Physiol Lung Cell Mol Physiol (2003) 1.24

Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis. J Am Soc Nephrol (2003) 1.22

Resident pleural macrophages are key orchestrators of neutrophil recruitment in pleural inflammation. Am J Respir Crit Care Med (2005) 1.22

Human kidney injury molecule-1 (hKIM-1): a useful immunohistochemical marker for diagnosing renal cell carcinoma and ovarian clear cell carcinoma. Am J Surg Pathol (2007) 1.22

Nephron organoids derived from human pluripotent stem cells model kidney development and injury. Nat Biotechnol (2015) 1.21

Macrophages and renal fibrosis. Semin Nephrol (2010) 1.21