Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

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Published in Nat Commun on April 07, 2017

Authors

Haikuo Zhang1,2, Christine Fillmore Brainson3,4,5, Shohei Koyama1,2, Amanda J Redig1,2, Ting Chen1,2, Shuai Li1,2, Manav Gupta3,4,5, Carolina Garcia-de-Alba3,4,5, Margherita Paschini3,4,5, Grit S Herter-Sprie1,2, Gang Lu1,2, Xin Zhang1,2, Bryan P Marsh3, Stephanie J Tuminello6, Chunxiao Xu1,2, Zhao Chen1,2, Xiaoen Wang1,2, Esra A Akbay1,2, Mei Zheng2, Sangeetha Palakurthi7, Lynette M Sholl1,2, Anil K Rustgi8, David J Kwiatkowski1,2, J Alan Diehl9, Adam J Bass1,2, Norman E Sharpless10, Glenn Dranoff1,2, Peter S Hammerman1,2, Hongbin Ji11,12, Nabeel Bardeesy13, Dieter Saur14,15, Hideo Watanabe7, Carla F Kim3,4,5, Kwok-Kin Wong1,2,7,16

Author Affiliations

1: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
2: Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
3: Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.
4: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
5: Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA.
6: Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
7: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
8: University of Pennsylvania Perelman School of Medicine, Division of Gastroenterology, Department of Medicine and Genetics, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA.
9: Department of Biochemical and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
10: University of North Carolina Lineberger Comprehensive Cancer Center, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA.
11: Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
12: School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China.
13: Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02144, USA.
14: Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München 81675, Germany.
15: German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
16: Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York 10016, USA.

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