Published in Neurotherapeutics on April 10, 2017
HCN Channel Targets for Novel Antidepressant Treatment. Neurotherapeutics (2017) 0.79
Moving Beyond Serendipity to Mechanism-Driven Psychiatric Therapeutics. Neurotherapeutics (2017) 0.75
Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry (1994) 48.75
Antidepressant effects of ketamine in depressed patients. Biol Psychiatry (2000) 10.91
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
A neurotrophic model for stress-related mood disorders. Biol Psychiatry (2006) 8.97
Neurobiology of depression. Neuron (2002) 8.56
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24
The mesolimbic dopamine reward circuit in depression. Biol Psychiatry (2006) 7.62
The molecular neurobiology of depression. Nature (2008) 6.51
A molecular and cellular theory of depression. Arch Gen Psychiatry (1997) 6.10
Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoS Med (2013) 6.04
Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. Trends Neurosci (2007) 4.98
Transient acute depression induced by high-frequency deep-brain stimulation. N Engl J Med (1999) 4.79
New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci (2006) 4.62
Psychobiological mechanisms of resilience and vulnerability: implications for successful adaptation to extreme stress. Am J Psychiatry (2004) 4.32
Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. Neuron (2011) 3.89
Psychobiology and molecular genetics of resilience. Nat Rev Neurosci (2009) 3.71
Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci (2011) 3.69
The locus coeruleus and noradrenergic modulation of cognition. Nat Rev Neurosci (2009) 3.67
Molecular and cellular basis of addiction. Science (1997) 3.57
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci (2010) 3.47
Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A (2004) 3.37
The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol (2007) 3.32
Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. Neurosci Biobehav Rev (2004) 3.10
The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol (2005) 3.09
Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry (2006) 3.00
Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature (2012) 2.88
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Preclinical models: status of basic research in depression. Biol Psychiatry (2002) 2.76
A standardized protocol for repeated social defeat stress in mice. Nat Protoc (2011) 2.57
Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54
Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry (1999) 2.39
Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry (2006) 2.36
Neurobiology of resilience. Nat Neurosci (2012) 2.13
Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention. Sci STKE (2004) 2.04
Exercise and depressive symptoms in adolescents: a longitudinal cohort study. JAMA Pediatr (2014) 2.03
A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron (2011) 1.92
Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry (2003) 1.78
Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J Neurosci (2010) 1.75
CRH Engagement of the Locus Coeruleus Noradrenergic System Mediates Stress-Induced Anxiety. Neuron (2015) 1.64
Developing an agenda for translational studies of resilience and vulnerability following trauma exposure. Ann N Y Acad Sci (2006) 1.62
A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression. J Neurosci (2011) 1.61
AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry (2008) 1.60
Stress-related noradrenergic activity prompts large-scale neural network reconfiguration. Science (2011) 1.55
Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats. Neuroscience (2009) 1.52
Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science (2014) 1.49
The epidemiological modelling of major depressive disorder: application for the Global Burden of Disease Study 2010. PLoS One (2013) 1.49
Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45
ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci (2013) 1.41
BDNF is a negative modulator of morphine action. Science (2012) 1.41
Risk and resilience in posttraumatic stress disorder. J Clin Psychiatry (2004) 1.34
The locus coeruleus as a site for integrating corticotropin-releasing factor and noradrenergic mediation of stress responses. Ann N Y Acad Sci (1993) 1.30
Prefrontal cortical circuit for depression- and anxiety-related behaviors mediated by cholecystokinin: role of ΔFosB. J Neurosci (2014) 1.28
Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Res (2009) 1.26
β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature (2014) 1.21
Glutamate receptor antagonists as fast-acting therapeutic alternatives for the treatment of depression: ketamine and other compounds. Annu Rev Pharmacol Toxicol (2014) 1.21
Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. Nat Neurosci (2013) 1.20
Serum response factor promotes resilience to chronic social stress through the induction of DeltaFosB. J Neurosci (2010) 1.19
Reward circuitry in resilience to severe trauma: an fMRI investigation of resilient special forces soldiers. Psychiatry Res (2009) 1.15
Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry (2008) 1.15
Different stressors produce excitation or inhibition of mesolimbic dopamine neuron activity: response alteration by stress pre-exposure. Eur J Neurosci (2012) 1.11
Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. Neurosci Lett (2011) 1.11
CRF acts in the midbrain to attenuate accumbens dopamine release to rewards but not their predictors. Nat Neurosci (2013) 1.09
Noradrenergic inhibition of midbrain dopamine neurons. J Neurosci (2004) 1.08
Chronic cold stress reduces the spontaneous activity of ventral tegmental dopamine neurons. Neuropsychopharmacology (2001) 1.08
Early adolescence as a critical window during which social stress distinctly alters behavior and brain norepinephrine activity. Neuropsychopharmacology (2010) 1.07
Molecular control of locus coeruleus neurotransmission. Biol Psychiatry (1999) 1.07
The mesolimbic dopamine system as a target for rapid antidepressant action. Int Clin Psychopharmacol (1997) 1.04
Increased phasic activity of VTA dopamine neurons in mice 3 weeks after repeated social defeat. Behav Brain Res (2010) 1.03
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat Commun (2015) 1.00
Noradrenergic modulation of the hyperpolarization-activated cation current (Ih) in dopamine neurons of the ventral tegmental area. Neuroscience (2007) 1.00
Amygdala-ventral pallidum pathway decreases dopamine activity after chronic mild stress in rats. Biol Psychiatry (2013) 1.00
ACF chromatin-remodeling complex mediates stress-induced depressive-like behavior. Nat Med (2015) 0.99
Resilience revisited. J Psychiatr Ment Health Nurs (2009) 0.95
Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility. Neuron (2016) 0.93
∆FosB: a transcriptional regulator of stress and antidepressant responses. Eur J Pharmacol (2014) 0.90
The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context. Neuroscience (2014) 0.83
Endogenous Opioids: The Downside of Opposing Stress. Neurobiol Stress (2015) 0.81
Antidepressant action of HDAC inhibition in the prefrontal cortex. Neuroscience (2015) 0.81
Essential Role of Mesolimbic Brain-Derived Neurotrophic Factor in Chronic Social Stress-Induced Depressive Behaviors. Biol Psychiatry (2015) 0.80
Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons. Nat Neurosci (2016) 0.79
KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. Nat Commun (2016) 0.79
Effects of social defeat on dopamine neurons in the ventral tegmental area in male and female California mice. Eur J Neurosci (2015) 0.78
Using high resolution imaging to determine trafficking of corticotropin-releasing factor receptors in noradrenergic neurons of the rat locus coeruleus. Life Sci (2014) 0.77
HCN Channel Targets for Novel Antidepressant Treatment. Neurotherapeutics (2017) 0.79