Published in Biol Psychiatry on May 12, 2006
The molecular neurobiology of depression. Nature (2008) 6.51
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry (2007) 2.93
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev (2012) 2.54
Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54
Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci (2012) 1.90
Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry (2009) 1.71
Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology (2012) 1.64
Role of CRF receptor signaling in stress vulnerability, anxiety, and depression. Ann N Y Acad Sci (2009) 1.59
Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci (2009) 1.58
Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. Mol Psychiatry (2011) 1.48
Vmat2 heterozygous mutant mice display a depressive-like phenotype. J Neurosci (2007) 1.45
Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects. Schizophr Bull (2009) 1.45
Control and function of the homeostatic sleep response by adenosine A1 receptors. J Neurosci (2009) 1.40
Brain-derived neurotrophic factor signaling and subgenual anterior cingulate cortex dysfunction in major depressive disorder. Am J Psychiatry (2012) 1.28
Structural and synaptic plasticity in stress-related disorders. Rev Neurosci (2011) 1.26
Antidepressant effects of ketamine: mechanisms underlying fast-acting novel antidepressants. Front Pharmacol (2013) 1.25
Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression. Dialogues Clin Neurosci (2009) 1.23
Antidepressant-like effects of intracerebroventricular FGF2 in rats. Brain Res (2008) 1.22
Antidepressant actions of ketamine: from molecular mechanisms to clinical practice. Curr Opin Neurobiol (2015) 1.22
The role of BDNF in depression on the basis of its location in the neural circuitry. Acta Pharmacol Sin (2010) 1.19
Antidepressant effects of TrkB ligands on depression-like behavior and dendritic changes in mice after inflammation. Int J Neuropsychopharmacol (2014) 1.18
Role of nuclear factor kappaB in ovarian hormone-mediated stress hypersensitivity in female mice. Biol Psychiatry (2009) 1.17
Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition? Neurosci Biobehav Rev (2010) 1.17
Gender-specific impact of brain-derived neurotrophic factor signaling on stress-induced depression-like behavior. Biol Psychiatry (2009) 1.16
Sex differences in animal models of psychiatric disorders. Br J Pharmacol (2014) 1.15
Fetal alcohol spectrum disorder-associated depression: evidence for reductions in the levels of brain-derived neurotrophic factor in a mouse model. Pharmacol Biochem Behav (2008) 1.14
Molecular and genetic substrates linking stress and addiction. Brain Res (2009) 1.11
Regulation of hippocampal progenitor cell survival, proliferation and dendritic development by BDNF. Mol Neurodegener (2009) 1.10
Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress. J Neurosci (2015) 1.10
Serum brain-derived neurotrophic factor: determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J Biol Psychiatry (2011) 1.08
Kv1.3 gene-targeted deletion alters longevity and reduces adiposity by increasing locomotion and metabolism in melanocortin-4 receptor-null mice. Int J Obes (Lond) (2008) 1.06
Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood? J Biosci (2006) 1.06
From synapse to nucleus: novel targets for treating depression. Neuropharmacology (2009) 1.06
Depression research: where are we now? Mol Brain (2010) 1.06
Ethanol-BDNF interactions: still more questions than answers. Pharmacol Ther (2008) 1.06
An excitatory synapse hypothesis of depression. Trends Neurosci (2015) 1.05
Chronic fluoxetine treatment induces brain region-specific upregulation of genes associated with BDNF-induced long-term potentiation. Neural Plast (2007) 1.05
Role of vascular endothelial growth factor in adult hippocampal neurogenesis: implications for the pathophysiology and treatment of depression. Behav Brain Res (2011) 1.01
Effects of inhibitor of κB kinase activity in the nucleus accumbens on emotional behavior. Neuropsychopharmacology (2012) 1.00
Mice with altered BDNF signaling as models for mood disorders and antidepressant effects. Front Behav Neurosci (2014) 0.99
Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. J Neurosci (2009) 0.99
A role for p11 in the antidepressant action of brain-derived neurotrophic factor. Biol Psychiatry (2010) 0.99
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade. PLoS One (2011) 0.99
Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice. Learn Mem (2011) 0.98
Distribution of phosphorylated TrkB receptor in the mouse hippocampal formation depends on sex and estrous cycle stage. J Neurosci (2011) 0.98
Cortical control of affective networks. J Neurosci (2013) 0.97
Epigenetics and psychiatry. Neurotherapeutics (2013) 0.96
Neurotrophins role in depression neurobiology: a review of basic and clinical evidence. Curr Neuropharmacol (2011) 0.96
Roles for gamma-aminobutyric acid in the development of the paraventricular nucleus of the hypothalamus. J Comp Neurol (2010) 0.95
Direct retino-raphe projection alters serotonergic tone and affective behavior. Neuropsychopharmacology (2013) 0.95
The neural plasticity theory of depression: assessing the roles of adult neurogenesis and PSA-NCAM within the hippocampus. Neural Plast (2013) 0.94
Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats. Cereb Cortex (2008) 0.94
The Role of Neurotrophins in Major Depressive Disorder. Transl Neurosci (2013) 0.94
Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biol Psychiatry (2008) 0.94
Brain-Derived Neurotrophic Factor (BDNF) protein levels in anxiety disorders: systematic review and meta-regression analysis. Front Integr Neurosci (2013) 0.94
BDNF-TrkB signaling through Erk1/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids. Mol Psychiatry (2013) 0.94
Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Front Neuroendocrinol (2013) 0.93
The BDNF effects on dendritic spines of mature hippocampal neurons depend on neuronal activity. Front Synaptic Neurosci (2014) 0.93
Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. Transl Psychiatry (2011) 0.93
BDNF - a key transducer of antidepressant effects. Neuropharmacology (2015) 0.93
Fluoxetine treatment induces dose dependent alterations in depression associated behavior and neural plasticity in female mice. Neurosci Lett (2010) 0.92
Are BDNF and glucocorticoid activities calibrated? Neuroscience (2012) 0.92
Chronic administration of mood stabilizers upregulates BDNF and bcl-2 expression levels in rat frontal cortex. Neurochem Res (2008) 0.92
Soluble beta amyloid(1-42): a critical player in producing behavioural and biochemical changes evoking depressive-related state? Br J Pharmacol (2010) 0.91
Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder. Ann Neurosci (2014) 0.90
Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets. Curr Neuropharmacol (2016) 0.89
Forebrain elimination of cacna1c mediates anxiety-like behavior in mice. Mol Psychiatry (2012) 0.89
Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV. Transl Psychiatry (2011) 0.89
Synaptic regulation of affective behaviors; role of BDNF. Neuropharmacology (2013) 0.89
Short-term striatal gene expression responses to brain-derived neurotrophic factor are dependent on MEK and ERK activation. PLoS One (2009) 0.89
Sex and stress hormone influences on the expression and activity of brain-derived neurotrophic factor. Neuroscience (2012) 0.88
Reconceptualizing sex, brain and psychopathology: interaction, interaction, interaction. Br J Pharmacol (2014) 0.88
BDNF-ERK-CREB signalling mediates the role of miR-132 in the regulation of the effects of oleanolic acid in male mice. J Psychiatry Neurosci (2014) 0.87
Nobiletin Ameliorates the Deficits in Hippocampal BDNF, TrkB, and Synapsin I Induced by Chronic Unpredictable Mild Stress. Evid Based Complement Alternat Med (2013) 0.87
Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling. Neuropsychopharmacology (2015) 0.87
Low dietary or supplemental zinc is associated with depression symptoms among women, but not men, in a population-based epidemiological survey. J Affect Disord (2011) 0.86
Activation of muscular TrkB by its small molecular agonist 7,8-dihydroxyflavone sex-dependently regulates energy metabolism in diet-induced obese mice. Chem Biol (2015) 0.86
Mood disorders in Huntington's disease: from behavior to cellular and molecular mechanisms. Front Behav Neurosci (2014) 0.86
Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Front Cell Neurosci (2014) 0.84
Prenatal cigarette smoke exposure causes hyperactivity and aggressive behavior: role of altered catecholamines and BDNF. Exp Neurol (2014) 0.84
Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders. J Child Psychol Psychiatry (2011) 0.84
Postnatal BDNF expression profiles in prefrontal cortex and hippocampus of a rat schizophrenia model induced by MK-801 administration. J Biomed Biotechnol (2010) 0.84
Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants. J Exp Biol (2015) 0.83
Sex differences in drug addiction and response to exercise intervention: From human to animal studies. Front Neuroendocrinol (2015) 0.83
Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice. Mol Cell Biol (2015) 0.83
Active commuting to school, cognitive performance, and academic achievement: an observational study in Dutch adolescents using accelerometers. BMC Public Health (2014) 0.81
Somatic drugs for psychiatric diseases: aspirin or simvastatin for depression? Curr Neuropharmacol (2012) 0.81
Neural Substrates of Depression and Resilience. Neurotherapeutics (2017) 0.81
Global and gene-specific DNA methylation alterations in the adolescent amygdala and hippocampus in an animal model of caregiver maltreatment. Behav Brain Res (2015) 0.80
Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats. Lipids Health Dis (2013) 0.80
Supplemental dietary choline during development exerts antidepressant-like effects in adult female rats. Brain Res (2012) 0.80
Protective effects of piperine against corticosterone-induced neurotoxicity in PC12 cells. Cell Mol Neurobiol (2011) 0.80
Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cell Mol Life Sci (2015) 0.80
Piperine reverses chronic unpredictable mild stress-induced behavioral and biochemical alterations in rats. Cell Mol Neurobiol (2014) 0.79
Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models. Front Psychiatry (2015) 0.79
Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity. Front Pharmacol (2013) 0.79
Expression of Nampt in hippocampal and cortical excitatory neurons is critical for cognitive function. J Neurosci (2014) 0.79
HCN Channel Targets for Novel Antidepressant Treatment. Neurotherapeutics (2017) 0.79
Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37
Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science (2006) 9.31
Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
Neurobiology of depression. Neuron (2002) 8.56
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24
The molecular neurobiology of depression. Nature (2008) 6.51
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00
The many faces of CREB. Trends Neurosci (2005) 5.58
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell (2005) 5.51
Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48
Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09
Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci (2006) 4.62
Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci (2003) 4.60
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res (2008) 3.99
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97
Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92
Psychobiology and molecular genetics of resilience. Nat Rev Neurosci (2009) 3.71
Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci (2011) 3.69
DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci (2010) 3.47
Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41
Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A (2004) 3.37
CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A (2002) 3.32
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17
Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15
The brain reward circuitry in mood disorders. Nat Rev Neurosci (2013) 3.08
The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci (2010) 3.02
Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01
Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97
CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci (2006) 2.95
Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95
Early life programming and neurodevelopmental disorders. Biol Psychiatry (2010) 2.93
Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry (2007) 2.93
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell (2012) 2.85
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84
IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci (2006) 2.71
DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res (2004) 2.67
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol (2002) 2.65
Neurofibromin regulation of ERK signaling modulates GABA release and learning. Cell (2008) 2.65
The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64
Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63
RGS9 modulates dopamine signaling in the basal ganglia. Neuron (2003) 2.61
ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab (2006) 2.55
Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54
Afferents to the GABAergic tail of the ventral tegmental area in the rat. J Comp Neurol (2009) 2.47
The molecular and genetic basis of neurological tumours. Nat Rev Cancer (2002) 2.41
Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron (2004) 2.38
Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry (2003) 2.37
Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A (2010) 2.36
Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res (2003) 2.30
Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci (2004) 2.30
DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci (2006) 2.29
Induction of deltaFosB in reward-related brain structures after chronic stress. J Neurosci (2004) 2.27
Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25
TrkB has a cell-autonomous role in the establishment of hippocampal Schaffer collateral synapses. J Neurosci (2005) 2.21
Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci (2002) 2.21
Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci (2012) 2.20
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci (2009) 2.18
Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A (2010) 2.17
An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci (2006) 2.17
Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration. J Neurosci (2002) 2.16
Molecular neurobiology of drug addiction. Annu Rev Med (2004) 2.16
Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci (2003) 2.16
Epigenetic mechanisms in drug addiction. Trends Mol Med (2008) 2.14
The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14
Neurobiology of resilience. Nat Neurosci (2012) 2.13
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell (2009) 2.12
CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci (2009) 2.11
Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A (2003) 2.08
Paternal transmission of stress-induced pathologies. Biol Psychiatry (2011) 2.07
PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci U S A (2009) 2.07
Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology (2007) 2.04
Neurotrophic factors and structural plasticity in addiction. Neuropharmacology (2008) 1.99
Perinatal exposure to bisphenol a alters early adipogenesis in the rat. Environ Health Perspect (2009) 1.98
DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci (2005) 1.95
Imatinib mesylate for plexiform neurofibromas in patients with neurofibromatosis type 1: a phase 2 trial. Lancet Oncol (2012) 1.95
Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr (2009) 1.95
Testis determination requires insulin receptor family function in mice. Nature (2003) 1.94
Loss of Insl3: a potential predisposing factor for testicular torsion. J Urol (2010) 1.93
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth. Proc Natl Acad Sci U S A (2005) 1.93
A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron (2011) 1.92