Published in JCI Insight on April 20, 2017
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol (2007) 33.06
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science (2004) 19.08
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology (2004) 18.86
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science (2006) 13.91
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell (2010) 10.96
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 8.14
Human fatty liver disease: old questions and new insights. Science (2011) 8.03
From endoplasmic-reticulum stress to the inflammatory response. Nature (2008) 7.17
Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell (2008) 6.83
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid Redox Signal (2007) 5.17
Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology (2005) 5.11
Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology (2001) 5.07
Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med (2002) 4.69
Endoplasmic reticulum stress in liver disease. J Hepatol (2010) 3.90
Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest (2001) 3.82
GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest (2009) 3.70
Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production. Cell Metab (2007) 3.69
Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci (2002) 3.64
Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. Cell Metab (2008) 3.45
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat Med (2011) 3.15
Hypothalamic sensing of fatty acids. Nat Neurosci (2005) 2.67
Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis (2001) 2.56
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell (2013) 2.43
Obesity and hypertension: two epidemics or one? Am J Physiol Regul Integr Comp Physiol (2004) 1.68
Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci U S A (2011) 1.52
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest (2012) 1.51
Obesity and nonalcoholic fatty liver disease. Nutr Rev (2007) 1.51
Unfolded protein response signaling and metabolic diseases. J Biol Chem (2013) 1.48
Increased prevalence of fatty liver in arterial hypertensive patients with normal liver enzymes: role of insulin resistance. Gut (2004) 1.44
Sensory circumventricular organs: central roles in integrated autonomic regulation. Regul Pept (2004) 1.37
Pathophysiology and treatment of obesity hypertension. Curr Pharm Des (2004) 1.37
Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems. Hypertension (2002) 1.27
Inflammatory cause of metabolic syndrome via brain stress and NF-κB. Aging (Albany NY) (2012) 1.24
The Framingham risk score and heart disease in nonalcoholic fatty liver disease. Liver Int (2012) 1.15
Hypothalamic control of energy metabolism via the autonomic nervous system. Ann N Y Acad Sci (2010) 1.11
Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension (2012) 1.09
Central ceramide-induced hypothalamic lipotoxicity and ER stress regulate energy balance. Cell Rep (2014) 1.06
Nervous control of liver metabolism and hemodynamics. Eur J Biochem (1992) 1.04
Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2014) 1.00
Circulating signals as critical regulators of autonomic state--central roles for the subfornical organ. Am J Physiol Regul Integr Comp Physiol (2010) 0.99
Sympathetic nervous system control of triglyceride metabolism: novel concepts derived from recent studies. J Lipid Res (2013) 0.96
The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects. Hypertension (2013) 0.95
Circumventricular organs: targets for integration of circulating fluid and energy balance signals? Physiol Behav (2013) 0.91
Hypertension and fatty liver: guilty by association? J Hum Hypertens (2007) 0.88
Angiotensin type 1a receptors in the forebrain subfornical organ facilitate leptin-induced weight loss through brown adipose tissue thermogenesis. Mol Metab (2015) 0.82
Brain glucose sensing, glucokinase and neural control of metabolism and islet function. Diabetes Obes Metab (2014) 0.82
Inflaming hypothalamic neurons raises blood pressure. Cell Metab (2011) 0.78
Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous system. Circ Res (2004) 4.12
Superoxide mediates the actions of angiotensin II in the central nervous system. Circ Res (2002) 3.29
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci (2003) 3.05
Obesity-associated hypertension: new insights into mechanisms. Hypertension (2004) 2.86
NADPH oxidases of the brain: distribution, regulation, and function. Antioxid Redox Signal (2006) 2.56
A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity. Proc Natl Acad Sci U S A (2007) 2.36
Hypertension and cerebrovascular dysfunction. Cell Metab (2008) 2.30
The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metab (2010) 2.26
Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes (2005) 2.24
Microdystrophin gene therapy of cardiomyopathy restores dystrophin-glycoprotein complex and improves sarcolemma integrity in the mdx mouse heart. Circulation (2003) 2.22
Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci (2003) 2.14
Increased muscle sympathetic nerve activity acutely alters conduit artery shear rate patterns. Am J Physiol Heart Circ Physiol (2010) 2.06
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of angiotensin II in the brain. Circ Res (2004) 1.98
Recommendations for blood pressure measurement in humans and experimental animals: part 2: blood pressure measurement in experimental animals: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Arterioscler Thromb Vasc Biol (2005) 1.82
Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circ Res (2002) 1.81
The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circ Res (2002) 1.81
Role of CuZn superoxide dismutase on carotid body function in heart failure rabbits. Cardiovasc Res (2008) 1.75
Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. J Clin Invest (2004) 1.74
Targeted viral delivery of Cre recombinase induces conditional gene deletion in cardiovascular circuits of the mouse brain. Physiol Genomics (2004) 1.74
Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes (2008) 1.60
Differential modulation of leptin-induced sympathoexcitation by baroreflex activation. J Hypertens (2002) 1.57
Nox2-containing NADPH oxidase and Akt activation play a key role in angiotensin II-induced cardiomyocyte hypertrophy. Physiol Genomics (2006) 1.57
Local production of angiotensin II in the subfornical organ causes elevated drinking. J Clin Invest (2007) 1.56
Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. Am J Physiol Regul Integr Comp Physiol (2013) 1.56
ER stress in the brain subfornical organ mediates angiotensin-dependent hypertension. J Clin Invest (2012) 1.51
Superoxide mediates angiotensin II-induced influx of extracellular calcium in neural cells. Hypertension (2005) 1.50
Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans. Exp Physiol (2010) 1.50
Redox signaling in central neural regulation of cardiovascular function. Prog Biophys Mol Biol (2004) 1.46
Genetic silencing of Nox2 and Nox4 reveals differential roles of these NADPH oxidase homologues in the vasopressor and dipsogenic effects of brain angiotensin II. Hypertension (2009) 1.45
Differential expression of neuronal ACE2 in transgenic mice with overexpression of the brain renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol (2006) 1.44
Reactive oxygen species in the neuropathogenesis of hypertension. Curr Hypertens Rep (2006) 1.40
Superoxide is involved in the central nervous system activation and sympathoexcitation of myocardial infarction-induced heart failure. Circ Res (2003) 1.37
The concept of selective leptin resistance: evidence from agouti yellow obese mice. Diabetes (2002) 1.37
Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers. J Comp Neurol (2009) 1.35
Role of the NADPH oxidases in the subfornical organ in angiotensin II-induced hypertension. Hypertension (2012) 1.33
Intracellular mechanisms involved in leptin regulation of sympathetic outflow. Hypertension (2002) 1.31
Chronic tempol prevents hypertension, proteinuria, and poor feto-placental outcomes in BPH/5 mouse model of preeclampsia. Hypertension (2008) 1.31
Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. J Biol Chem (2002) 1.30
Selective gene transfer to key cardiovascular regions of the brain: comparison of two viral vector systems. Hypertension (2002) 1.27
Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circ Res (2011) 1.27
Control of hepatic nuclear superoxide production by glucose 6-phosphate dehydrogenase and NADPH oxidase-4. J Biol Chem (2011) 1.26
Central sympathetic overactivity: maladies and mechanisms. Auton Neurosci (2009) 1.25
The cerebrovascular dysfunction induced by slow pressor doses of angiotensin II precedes the development of hypertension. Am J Physiol Heart Circ Physiol (2010) 1.24
Increased brachial artery retrograde shear rate at exercise onset is abolished during prolonged cycling: role of thermoregulatory vasodilation. J Appl Physiol (1985) (2010) 1.23
Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. Am J Physiol Endocrinol Metab (2004) 1.23
Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension (2008) 1.23
Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circ Res (2006) 1.20
A differential role for endocytosis in receptor-mediated activation of Nox1. Antioxid Redox Signal (2010) 1.20
Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiol Genomics (2004) 1.17
A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. Am J Physiol Heart Circ Physiol (2012) 1.14
Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans. J Physiol (2010) 1.13
Severe feto-placental abnormalities precede the onset of hypertension and proteinuria in a mouse model of preeclampsia. Biol Reprod (2006) 1.12
Endothelin 1-dependent neurovascular dysfunction in chronic intermittent hypoxia. Hypertension (2012) 1.11
Silencing nox4 in the paraventricular nucleus improves myocardial infarction-induced cardiac dysfunction by attenuating sympathoexcitation and periinfarct apoptosis. Circ Res (2010) 1.10
The vascular supply of the functional compartments of the human striatum. Brain (2006) 1.10
Angiotensin II-dependent hypertension requires cyclooxygenase 1-derived prostaglandin E2 and EP1 receptor signaling in the subfornical organ of the brain. Hypertension (2012) 1.09
Abnormal development of NG2+PDGFR-α+ neural progenitor cells leads to neonatal hydrocephalus in a ciliopathy mouse model. Nat Med (2012) 1.08
Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. Circ Res (2004) 1.08
Selective resistance to central neural administration of leptin in agouti obese mice. Hypertension (2002) 1.07
Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension (2004) 1.06
Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension. J Neurosci (2012) 1.06
Bilateral limbic system destruction in man. J Clin Exp Neuropsychol (2010) 1.05
Targeted inhibition of complement activation prevents features of preeclampsia in mice. Kidney Int (2010) 1.04
Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension (2012) 1.03
Scavenging superoxide selectively in mouse forebrain is associated with improved cardiac function and survival following myocardial infarction. Am J Physiol Regul Integr Comp Physiol (2008) 1.02
Contrasting effects of leptin on food anticipatory and total locomotor activity. PLoS One (2011) 1.01
Tertiary microvascular territories define lacunar infarcts in the basal ganglia. Ann Neurol (2005) 1.01
Adenoviral delivery of VEGF121 early in pregnancy prevents spontaneous development of preeclampsia in BPH/5 mice. Hypertension (2010) 0.99
Antiviral effects of lamivudine, emtricitabine, adefovir dipivoxil, and tenofovir disoproxil fumarate administered orally alone and in combination to woodchucks with chronic woodchuck hepatitis virus infection. Antimicrob Agents Chemother (2008) 0.99
Multiple forebrain systems converge on motor neurons innervating the thyroarytenoid muscle. Neuroscience (2009) 0.99
Kidney-induced hypertension depends on superoxide signaling in the rostral ventrolateral medulla. Hypertension (2010) 0.98
Transfer function characteristics of the neural and peripheral arterial baroreflex arcs at rest and during postexercise muscle ischemia in humans. Am J Physiol Heart Circ Physiol (2009) 0.97
Leptin potentiates thermogenic sympathetic responses to hypothermia: a receptor-mediated effect. Diabetes (2002) 0.96
In vivo bioluminescence imaging reveals redox-regulated activator protein-1 activation in paraventricular nucleus of mice with renovascular hypertension. Hypertension (2010) 0.96
The brain subfornical organ mediates leptin-induced increases in renal sympathetic activity but not its metabolic effects. Hypertension (2013) 0.95
Recommendations for blood pressure measurement in animals: summary of an AHA scientific statement from the Council on High Blood Pressure Research, Professional and Public Education Subcommittee. Arterioscler Thromb Vasc Biol (2005) 0.94
Pro-atherogenic shear rate patterns in the femoral artery of healthy older adults. Atherosclerosis (2010) 0.93
Regulation of middle cerebral artery blood velocity during dynamic exercise in humans: influence of aging. J Appl Physiol (1985) (2008) 0.92
Long-term neuropsychological, neuroanatomical, and life outcome in hippocampal amnesia. Clin Neuropsychol (2012) 0.92
Comparing resting skin sympathetic nerve activity between groups: caution needed. J Appl Physiol (1985) (2009) 0.91
Carotid baroreflex control of arterial blood pressure at rest and during dynamic exercise in aging humans. Am J Physiol Regul Integr Comp Physiol (2010) 0.90
Influence of ageing on carotid baroreflex peak response latency in humans. J Physiol (2009) 0.90
Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. Physiol Genomics (2004) 0.90
AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Sci Transl Med (2012) 0.89