Published in Virology on September 01, 1988
Genetic evidence for two distinct transactivation functions of the herpes simplex virus alpha protein ICP27. J Virol (1990) 3.63
An activity specified by the osteosarcoma line U2OS can substitute functionally for ICP0, a major regulatory protein of herpes simplex virus type 1. J Virol (1995) 2.82
ICP4, the major transcriptional regulatory protein of herpes simplex virus type 1, forms a tripartite complex with TATA-binding protein and TFIIB. J Virol (1993) 2.16
The regions important for the activator and repressor functions of herpes simplex virus type 1 alpha protein ICP27 map to the C-terminal half of the molecule. J Virol (1989) 1.99
Identification of functional regions of herpes simplex virus glycoprotein gD by using linker-insertion mutagenesis. J Virol (1994) 1.85
DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus. Nucleic Acids Res (1989) 1.80
The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation. Nucleic Acids Res (1988) 1.78
Visualization of parental HSV-1 genomes and replication compartments in association with ND10 in live infected cells. EMBO J (2002) 1.57
Repression of the herpes simplex virus 1 alpha 4 gene by its gene product occurs within the context of the viral genome and is associated with all three identified cognate sites. Proc Natl Acad Sci U S A (1993) 1.56
Interaction of the viral activator protein ICP4 with TFIID through TAF250. Mol Cell Biol (1996) 1.56
The ICP4 binding sites in the herpes simplex virus type 1 glycoprotein D (gD) promoter are not essential for efficient gD transcription during virus infection. J Virol (1992) 1.51
Functional interactions between herpes simplex virus immediate-early proteins during infection: gene expression as a consequence of ICP27 and different domains of ICP4. J Virol (1995) 1.48
Amino acid substitution mutations in the herpes simplex virus ICP27 protein define an essential gene regulation function. J Virol (1994) 1.45
Physical interaction between the herpes simplex virus type 1 immediate-early regulatory proteins ICP0 and ICP4. J Virol (1994) 1.45
Functional relevance of specific interactions between herpes simplex virus type 1 ICP4 and sequences from the promoter-regulatory domain of the viral thymidine kinase gene. J Virol (1990) 1.44
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4. J Virol (1989) 1.40
Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene. J Virol (1991) 1.37
Substitution of a TATA box from a herpes simplex virus late gene in the viral thymidine kinase promoter alters ICP4 inducibility but not temporal expression. J Virol (1992) 1.27
Activities of heterodimers composed of DNA-binding- and transactivation-deficient subunits of the herpes simplex virus regulatory protein ICP4. J Virol (1991) 1.27
Characterization of the regulatory functions of the equine herpesvirus 1 immediate-early gene product. J Virol (1992) 1.25
Requirements for activation of the herpes simplex virus glycoprotein C promoter in vitro by the viral regulatory protein ICP4. J Virol (1994) 1.22
Codons 262 to 490 from the herpes simplex virus ICP4 gene are sufficient to encode a sequence-specific DNA binding protein. Nucleic Acids Res (1990) 1.21
trans-dominant inhibition of herpes simplex virus transcriptional regulatory protein ICP4 by heterodimer formation. J Virol (1990) 1.20
A second-site revertant of a defective herpes simplex virus ICP4 protein with restored regulatory activities and impaired DNA-binding properties. J Virol (1991) 1.19
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication. J Virol (1996) 1.17
Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB. Mol Cell Biol (1995) 1.17
Herpes simplex virus immediate-early proteins ICP0 and ICP4 activate the endogenous human alpha-globin gene in nonerythroid cells. J Virol (1997) 1.10
ICP4, the major regulatory protein of herpes simplex virus, shares features common to GTP-binding proteins and is adenylated and guanylated. J Virol (1991) 1.09
Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA. J Virol (2000) 1.08
Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein BICP0. J Virol (1994) 1.08
The transcriptional activation domain of varicella-zoster virus open reading frame 62 protein is not conserved with its herpes simplex virus homolog. J Virol (1993) 1.07
Analysis of phosphorylation sites of herpes simplex virus type 1 ICP4. J Virol (1996) 1.04
The polyserine tract of herpes simplex virus ICP4 is required for normal viral gene expression and growth in murine trigeminal ganglia. J Virol (1998) 1.04
Differences in the poly(ADP-ribosyl)ation patterns of ICP4, the herpes simplex virus major regulatory protein, in infected cells and in isolated nuclei. J Virol (1992) 1.03
The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1. Nucleic Acids Res (1993) 1.03
Identification of C3b-binding regions on herpes simplex virus type 2 glycoprotein C. J Virol (1990) 1.02
Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells. J Virol (2011) 1.00
Mutational analysis of varicella-zoster virus major immediate-early protein IE62. Nucleic Acids Res (1995) 0.96
Purification of the DNA binding domain of herpes simplex virus type 1 immediate-early protein Vmw175 as a homodimer and extensive mutagenesis of its DNA recognition site. Nucleic Acids Res (1991) 0.95
Nuclear localization and transcriptional activation activities of truncated versions of the immediate-early gene product of equine herpesvirus 1. J Virol (1995) 0.93
Nucleotides within both proximal and distal parts of the consensus sequence are important for specific DNA recognition by the herpes simplex virus regulatory protein ICP4. Nucleic Acids Res (1991) 0.92
Differential dependence of herpes simplex virus immediate-early gene expression on de novo-infected cell protein synthesis. J Virol (1991) 0.92
Repression of the alpha0 gene by ICP4 during a productive herpes simplex virus infection. J Virol (1996) 0.92
The major transcriptional regulatory protein of herpes simplex virus type 1 includes a protease resistant DNA binding domain. Nucleic Acids Res (1990) 0.92
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic Acids Res (1994) 0.88
The high mobility group protein 1 is a coactivator of herpes simplex virus ICP4 in vitro. J Virol (1998) 0.88
The DNA binding domains of the varicella-zoster virus gene 62 and herpes simplex virus type 1 ICP4 transactivator proteins heterodimerize and bind to DNA. Nucleic Acids Res (1994) 0.88
Identification of a promoter-specific transactivation domain in the herpes simplex virus regulatory protein ICP4. J Virol (1997) 0.87
Activity of the simian virus 40 early promoter-enhancer in herpes simplex virus type 1 vectors is dependent on its position, the infected cell type, and the presence of Vmw175. J Virol (1991) 0.86
DNA-dependent oligomerization of herpes simplex virus type 1 regulatory protein ICP4. J Virol (2007) 0.86
The potential link between PML NBs and ICP0 in regulating lytic and latent infection of HSV-1. Protein Cell (2012) 0.85
Temperature-dependent conformational changes in herpes simplex virus ICP4 that affect transcription activation. J Virol (2003) 0.85
Requirement of the N-terminal activation domain of herpes simplex virus ICP4 for viral gene expression. J Virol (2012) 0.84
Localization of a 34-amino-acid segment implicated in dimerization of the herpes simplex virus type 1 ICP4 polypeptide by a dimerization trap. J Virol (1994) 0.83
The N terminus and C terminus of herpes simplex virus 1 ICP4 cooperate to activate viral gene expression. J Virol (2012) 0.80
Identification of a motif in the C terminus of herpes simplex virus regulatory protein ICP4 that contributes to activation of transcription. J Virol (2002) 0.78
Functional Characterization of the Serine-Rich Tract of Varicella-Zoster Virus IE62. J Virol (2015) 0.76
The intrinsic disorder alphabet. III. Dual personality of serine. Intrinsically Disord Proteins (2015) 0.75
Trans activation of transcription by herpes virus products: requirement for two HSV-1 immediate-early polypeptides for maximum activity. EMBO J (1984) 7.33
The repeated GC-rich motifs upstream from the TATA box are important elements of the SV40 early promoter. Nucleic Acids Res (1983) 4.93
The nuclear location of PML, a cellular member of the C3HC4 zinc-binding domain protein family, is rearranged during herpes simplex virus infection by the C3HC4 viral protein ICP0. J Gen Virol (1994) 4.32
Characterization of the IE110 gene of herpes simplex virus type 1. J Gen Virol (1986) 4.19
Nuclear domain 10 as preexisting potential replication start sites of herpes simplex virus type-1. Virology (1996) 3.62
A detailed analysis of an HSV-1 early promoter: sequences involved in trans-activation by viral immediate-early gene products are not early-gene specific. Nucleic Acids Res (1984) 3.31
The products of herpes simplex virus type 1 (HSV-1) immediate early genes 1, 2 and 3 can activate HSV-1 gene expression in trans. J Gen Virol (1986) 3.15
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase. J Virol (1999) 2.93
DNA sequence elements required for regulated expression of the HSV-1 glycoprotein D gene lie within 83 bp of the RNA capsites. Nucleic Acids Res (1983) 2.81
Herpes simplex virus type 1 immediate-early protein Vmw110 reactivates latent herpes simplex virus type 2 in an in vitro latency system. J Virol (1989) 2.76
Mutational dissection of the 21 bp repeat region of the SV40 early promoter reveals that it contains overlapping elements of the early-early and late-early promoters. Nucleic Acids Res (1984) 2.52
Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 affect cellular structures and proteins. J Virol (2000) 2.25
Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. J Biol Chem (2000) 2.10
Trans activation of plasmid-borne promoters by adenovirus and several herpes group viruses. Nucleic Acids Res (1984) 1.93
The regions of the herpes simplex virus type 1 immediate early protein Vmw175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation. Nucleic Acids Res (1988) 1.78
Herpes simplex virus type 1 immediate-early protein Vmw110 inhibits progression of cells through mitosis and from G(1) into S phase of the cell cycle. J Virol (1999) 1.66
Inactivation of the shutoff gene (UL41) of herpes simplex virus types 1 and 2. J Gen Virol (1990) 1.65
The product of gene US11 of herpes simplex virus type 1 is expressed as a true late gene. J Gen Virol (1986) 1.63
The control of herpes simplex virus type-1 late gene transcription: a 'TATA-box'/cap site region is sufficient for fully efficient regulated activity. Nucleic Acids Res (1986) 1.58
A rapid and efficient method for region- and strand-specific mutagenesis of cloned DNA. EMBO J (1982) 1.57
The ICP4 binding sites in the herpes simplex virus type 1 glycoprotein D (gD) promoter are not essential for efficient gD transcription during virus infection. J Virol (1992) 1.51
Control of expression of the varicella-zoster virus major immediate early gene. J Gen Virol (1990) 1.43
The product of varicella-zoster virus gene 62 autoregulates its own promoter. J Gen Virol (1990) 1.43
ICP4-binding sites in the promoter and coding regions of the herpes simplex virus gD gene contribute to activation of in vitro transcription by ICP4. J Virol (1989) 1.40
Activation of cellular promoters during herpes virus infection of biochemically transformed cells. EMBO J (1985) 1.39
A herpes simplex virus type 1 recombinant with both copies of the Vmw175 coding sequences replaced by the homologous varicella-zoster virus open reading frame. J Gen Virol (1990) 1.34
The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2. J Biol Chem (1999) 1.33
The adenovirus type 5 E1b 55K and E4 Orf3 proteins associate in infected cells and affect ND10 components. J Gen Virol (1999) 1.30
Transfer of UL41, the gene controlling virion-associated host cell shutoff, between different strains of herpes simplex virus. J Gen Virol (1990) 1.25
A prominent serine-rich region in Vmw175, the major transcriptional regulator protein of herpes simplex virus type 1, is not essential for virus growth in tissue culture. J Gen Virol (1990) 1.19
Expression of a cellular gene cloned in herpes simplex virus: rabbit beta-globin is regulated as an early viral gene in infected fibroblasts. J Virol (1987) 1.19
DNA replication is required for abundant expression of a plasmid-borne late US11 gene of herpes simplex virus type 1. Nucleic Acids Res (1986) 1.06
The herpes simplex virus type 1 immediate-early protein ICP0 is necessary for the efficient establishment of latent infection. J Virol (1997) 1.06
Alphaherpesvirus proteins related to herpes simplex virus type 1 ICP0 induce the formation of colocalizing, conjugated ubiquitin. J Virol (2001) 1.04
The DNA binding domain of the varicella-zoster virus gene 62 protein interacts with multiple sequences which are similar to the binding site of the related protein of herpes simplex virus type 1. Nucleic Acids Res (1993) 1.03
A mutant of herpes simplex virus type 1 immediate early polypeptide Vmw175 binds to the cap site of its own promoter in vitro but fails to autoregulate in vivo. J Gen Virol (1990) 0.97
Human neuron-committed teratocarcinoma NT2 cell line has abnormal ND10 structures and is poorly infected by herpes simplex virus type 1. J Virol (2001) 0.96
SUMO modification of E1B-55K oncoprotein regulates isoform-specific binding to the tumour suppressor protein PML. Oncogene (2010) 0.94
Nucleotides within both proximal and distal parts of the consensus sequence are important for specific DNA recognition by the herpes simplex virus regulatory protein ICP4. Nucleic Acids Res (1991) 0.92
The DNA binding domains of the varicella-zoster virus gene 62 and herpes simplex virus type 1 ICP4 transactivator proteins heterodimerize and bind to DNA. Nucleic Acids Res (1994) 0.88
Mutation of a single lysine residue severely impairs the DNA recognition and regulatory functions of the VZV gene 62 transactivator protein. Nucleic Acids Res (1994) 0.88
Mutations which alter the DNA binding properties of the herpes simplex virus type 1 transactivating protein Vmw175 also affect its ability to support virus replication. J Gen Virol (1997) 0.86
DNA replication of bacteriophage T5. 3. Studies on the structure of concatemeric T5 DNA. J Gen Virol (1981) 0.85
Replacement of the herpes simplex virus type 1 Vmw175 DNA binding domain with its varicella-zoster virus counterpart results in a protein with novel regulatory properties that can support virus growth. J Gen Virol (1997) 0.76
DNA replication of bacteriophage T5. 2. Structure and properties of the slow sedimenting form of intracellular T5 DNA. J Gen Virol (1980) 0.76
Activation of gene expression by human herpesvirus 6 is reporter gene-dependent. J Gen Virol (1991) 0.75
Assignment1 of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization. Cytogenet Cell Genet (1998) 0.75
DNA replication of bacteriophage T5. 1. Fractionation of intracellular T5 DNA by agarose gel electrophoresis. J Gen Virol (1980) 0.75