Published in Antimicrob Agents Chemother on September 01, 1988
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes. Microbiol Rev (1993) 9.38
Aminoglycoside modifying enzymes. Drug Resist Updat (2010) 3.19
Correlation between aminoglycoside resistance profiles and DNA hybridization of clinical isolates. Antimicrob Agents Chemother (1991) 1.62
Appearance of amikacin and tobramycin resistance due to 4'-aminoglycoside nucleotidyltransferase [ANT(4')-II] in gram-negative pathogens. Antimicrob Agents Chemother (1990) 1.59
Cloning, sequencing, and use as a molecular probe of a gene encoding an aminoglycoside 6'-N-acetyltransferase of broad substrate profile. Antimicrob Agents Chemother (1991) 1.59
Dissemination of amikacin resistance gene aphA6 in Acinetobacter spp. Antimicrob Agents Chemother (1990) 1.50
Nosocomial spread of an amikacin resistance gene on both a mobilized, nonconjugative plasmid and a conjugative plasmid. Antimicrob Agents Chemother (1991) 0.90
Increased resistance to amikacin in a neonatal unit following intensive amikacin usage. Antimicrob Agents Chemother (1992) 0.85
KPC-producing Klebsiella pneumoniae strains that harbor AAC(6')-Ib exhibit intermediate resistance to amikacin. Antimicrob Agents Chemother (2014) 0.83
Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics. J Antibiot (Tokyo) (2016) 0.75
A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res (1979) 214.95
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers. Gene (1982) 102.30
Plasmid insertion mutagenesis and lac gene fusion with mini-mu bacteriophage transposons. J Bacteriol (1984) 12.63
Nucleotide sequence of the kanamycin resistance transposon Tn903. J Mol Biol (1981) 12.25
Aminoglycoside-modifying enzymes. Methods Enzymol (1975) 8.38
Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III. Gene (1983) 8.32
In vivo formation of gene fusions encoding hybrid beta-galactosidase proteins in one step with a transposable Mu-lac transducing phage. Proc Natl Acad Sci U S A (1984) 3.06
DNA sequence of the E. coli gyrB gene: application of a new sequencing strategy. Nucleic Acids Res (1987) 2.93
Nucleotide sequence of a streptomycete aminoglycoside phosphotransferase gene and its relationship to phosphotransferases encoded by resistance plasmids. Proc Natl Acad Sci U S A (1983) 2.87
Transposon mutagenesis of marine Vibrio spp. J Bacteriol (1984) 2.29
Amikacin-resistant gram-negative bacilli: correlation of occurrence with amikacin use. J Infect Dis (1985) 1.92
Transferable amikacin resistance in Acinetobacter spp. due to a new type of 3'-aminoglycoside phosphotransferase. Antimicrob Agents Chemother (1988) 1.90
Epidemiological studies of aminoglycoside resistance in the U.S.A. J Antimicrob Chemother (1981) 1.75
Development of two DNA probes for differentiating the structural genes of subclasses I and II of the aminoglycoside-modifying enzyme 3'-aminoglycoside phosphotransferase. Antimicrob Agents Chemother (1985) 1.42
Evolution and transfer of aminoglycoside resistance genes under natural conditions. J Antimicrob Chemother (1986) 1.40
Long-term amikacin use. Effects on aminoglycoside susceptibility patterns of gram-negative bacilli. JAMA (1982) 1.31
High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake. Antimicrob Agents Chemother (1986) 1.25
Aminoglycoside 3'-phosphotransferase III, a new phosphotransferase. Resistance mechanism. J Antibiot (Tokyo) (1975) 1.19
Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase. Antimicrob Agents Chemother (1985) 0.99
Susceptibility of aerobic gram-negative bacilli to aminoglycosides. Effects of 45 months of amikacin as first-line aminoglycoside therapy. Am J Med (1986) 0.96
Patterns and mechanisms of emergence of resistance to amikacin. J Infect Dis (1977) 0.92
Replacement of a phosphoenolpyruvate-dependent phosphotransferase by a nicotinamide adenine dinucleotide-linked dehydrogenase for the utilization of mannitol. J Bacteriol (1967) 9.88
Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis (1986) 4.92
Simplified radioenzymatic assay for chloramphenicol. Antimicrob Agents Chemother (1978) 3.96
Characterization of swine infertility and respiratory syndrome (SIRS) virus (isolate ATCC VR-2332). J Vet Diagn Invest (1992) 3.75
Protein docking using continuum electrostatics and geometric fit. Protein Eng (2001) 3.48
Community-acquired pneumonia. Lancet (1998) 3.21
Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections. Infect Immun (1976) 3.08
Important elements of outpatient care: a comparison of patients' and physicians' opinions. Ann Intern Med (1996) 2.79
Emergence of teicoplanin resistance during therapy of Staphylococcus aureus endocarditis. J Infect Dis (1990) 2.44
Chief complaint of fatigue: a prospective study. J Fam Pract (1990) 2.25
Computer use and needs of internists: a survey of members of the American College of Physicians-American Society of Internal Medicine. Proc AMIA Symp (2000) 2.22
Assessment of function in routine clinical practice: description of the COOP Chart method and preliminary findings. J Chronic Dis (1987) 2.14
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis. Antimicrob Agents Chemother (1998) 2.13
Plasmid deoxyribonucleic acid in clinical isolates of Neisseria gonorrhoeae. J Bacteriol (1975) 2.11
Cutaneous abscesses. Anaerobic and aerobic bacteriology and outpatient management. Ann Intern Med (1977) 2.08
Elucidation of the role of arginine-244 in the turnover processes of class A beta-lactamases. Biochemistry (1992) 1.96
Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob Agents Chemother (1999) 1.90
Innervation of intracranial arteries. Brain (1970) 1.90
Hearing impairment as a determinant of function in the elderly. J Am Geriatr Soc (1989) 1.77
A novel gentamicin resistance gene in Enterococcus. Antimicrob Agents Chemother (1997) 1.63
Characterization of fluoroquinolone-resistant mutant strains of Mycobacterium tuberculosis selected in the laboratory and isolated from patients. Antimicrob Agents Chemother (1995) 1.54
Functional health status levels of primary care patients. JAMA (1983) 1.52
Amikacin resistance associated with a plasmid-borne aminoglycoside phosphotransferase in Escherichia coli. Antimicrob Agents Chemother (1979) 1.51
Detection of U.S., Lelystad, and European-like porcine reproductive and respiratory syndrome viruses and relative quantitation in boar semen and serum samples by real-time PCR. J Clin Microbiol (2004) 1.50
Lateralized attentional abnormality in schizophrenia is correlated with severity of symptoms. Biol Psychiatry (1993) 1.50
Eleven-CIS vitamin A in the treatment of retinitis pigmentosa. A negative study. Arch Ophthalmol (1968) 1.45
The clinical use of fluoroquinolones for the treatment of mycobacterial diseases. Clin Infect Dis (1997) 1.41
Effects on substrate profile by mutational substitutions at positions 164 and 179 of the class A TEM(pUC19) beta-lactamase from Escherichia coli. J Biol Chem (1999) 1.39
Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene. Antimicrob Agents Chemother (1998) 1.38
Serious infections due to penicillin-resistant strains of viridans streptococci with altered penicillin-binding proteins. J Infect Dis (1988) 1.34
Benefits and obstacles of health status assessment in ambulatory settings. The clinician's point of view. The Dartmouth Primary Care COOP Project. Med Care (1992) 1.32
Resistance to imipenem in Pseudomonas aeruginosa: clinical experience and biochemical mechanisms. Rev Infect Dis (1988) 1.30
Teicoplanin pharmacokinetics in intravenous drug abusers being treated for bacterial endocarditis. Antimicrob Agents Chemother (1991) 1.29
Economic-based projections of future land use in the conterminous United States under alternative policy scenarios. Ecol Appl (2012) 1.28
Relaxation therapy and high blood pressure. Arch Gen Psychiatry (1977) 1.27
Effects of Asp-179 mutations in TEMpUC19 beta-lactamase on susceptibility to beta-lactams. Antimicrob Agents Chemother (1995) 1.25
High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake. Antimicrob Agents Chemother (1986) 1.25
Characteristics of pathogenic Neisseria spp. isolated from homosexual men. J Clin Microbiol (1983) 1.24
Fibrin sealant reduces the duration and amount of fluid drainage after axillary dissection: a randomized prospective clinical trial. J Am Coll Surg (2001) 1.22
Localization of an amikacin 3'-phosphotransferase in Escherichia coli. J Bacteriol (1981) 1.22
Reversal of clavulanate resistance conferred by a Ser-244 mutant of TEM-1 beta-lactamase as a result of a second mutation (Arg to Ser at position 164) that enhances activity against ceftazidime. Antimicrob Agents Chemother (1994) 1.21
Shoulder pain in wheelchair athletes. The role of muscle imbalance. Am J Sports Med (1993) 1.21
Brain systems for the mediation of social separation-distress and social-reward. Evolutionary antecedents and neuropeptide intermediaries. Ann N Y Acad Sci (1997) 1.20
A randomised controlled trial to assess the impact of a package comprising a patient-orientated, evidence-based self-help guidebook and patient-centred consultations on disease management and satisfaction in inflammatory bowel disease. Health Technol Assess (2003) 1.18
Prevalence and site-pathogen studies of Neisseria meningitidis and N gonorrhoeae in homosexual men. JAMA (1980) 1.18
At least four percent of the Salmonella typhimurium genome is required for fatal infection of mice. Infect Immun (1998) 1.17
Porcine reproductive and respiratory syndrome virus productively infects monocyte-derived dendritic cells and compromises their antigen-presenting ability. Arch Virol (2006) 1.14
Association between major depressive disorder and physical illness. Psychol Med (1993) 1.13
Effect of highly potent antipseudomonal beta-lactam agents alone and in combination with aminoglycosides against Pseudomonas aeruginosa. Rev Infect Dis (1987) 1.11
Tubular bodies in vascular endothelium of a cerebellar neoplasm. Lab Invest (1974) 1.11
White cell-reduced platelet concentrates prepared by in-line filtration of platelet-rich plasma. Transfusion (1995) 1.11
Comparative study of ototoxicity and nephrotoxicity in patients randomly assigned to treatment with amikacin or gentamicin. Am J Med (1986) 1.10
A comparative study of the broth micro- and macro-dilution techniques for the determination of the in vitro susceptibility of Aspergillus fumigatus. Can J Microbiol (1996) 1.08
Aminoglycoside resistance genes aph(2")-Ib and aac(6')-Im detected together in strains of both Escherichia coli and Enterococcus faecium. Antimicrob Agents Chemother (2001) 1.07
Capitation for medical care. The importance of health status in older patients. Med Care (1987) 1.06
Electron microscopic observations on human intracranial arteries. Changes seen with aging and atherosclerosis. Arch Neurol (1967) 1.05
Efficacy and safety of tolterodine in patients with detrusor instability: a dose-ranging study. Br J Urol (1998) 1.05
Purification and characterization of aminoglycoside 3'-phosphotransferase type IIa and kinetic comparison with a new mutant enzyme. Antimicrob Agents Chemother (1994) 1.05
Effects of 3-5 log10 pre-storage leucocyte depletion on red cell storage and metabolism. Br J Haematol (1994) 1.05
Smac mimetics: implications for enhancement of targeted therapies in leukemia. Leukemia (2010) 1.05
Mechanisms of action of chloroalanyl antibacterial peptides. Identification of the intracellular enzymes inactivated on treatment of Escherichia coli JSR-O with the dipeptide beta Cl-LAla-beta Cl-LAla. J Biol Chem (1986) 1.03
Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase. Antimicrob Agents Chemother (1993) 1.02
Effect of clavulanic acid on the in vitro synergism between carbenicillin and gentamicin against Serratia marcescens. Antimicrob Agents Chemother (1979) 1.01
A model for predicting nephrotoxicity in patients treated with aminoglycosides. J Infect Dis (1986) 1.01
In vitro activity of gentamicin, amikacin and netilmicin alone and in combination with carbenicillin against Serratia marcescens. Antimicrob Agents Chemother (1976) 1.00
An integrative approach for studying the etiology of alcoholism and other addictions. Twin Res (2001) 0.99
Correlation of aminoglycoside resistance with the KmS and Vmax/Km ratios of enzymatic modification of aminoglycosides by 2''-O-nucleotidyltransferase. Antimicrob Agents Chemother (1985) 0.99
Brain opioids and mother-infant social motivation. Acta Paediatr Suppl (1994) 0.99
Auxotypes, penicillin susceptibility, and serogroups of Neisseria gonorrhoeae from disseminated and uncomplicated infections. J Infect Dis (1986) 0.97
Aspergillus terreus osteomyelitis. Arch Intern Med (1977) 0.97
Clinical isolation and characterization of aminoglycoside-resistant small colony variants of Enterobacter aerogenes. Am J Med (1979) 0.96
Cold face test in the assessment of trigeminal-brainstem-vagal function in humans. Ann Neurol (1980) 0.95
Disseminated blastomycosis in a pregnant woman: review of amphotericin B usage during pregnancy. Am Rev Respir Dis (1982) 0.95
Comparative clinical studies of ototoxicity and nephrotoxicity of amikacin and gentamicin. Am J Med (1977) 0.95
Management of the suicidal patient with schizophrenia.. Psychiatr Clin North Am (1997) 0.94
Isolation and characterization of a species-specific DNA probe for Candida albicans. Nucleic Acids Res (1991) 0.93
The short-term effect of patient health status assessment in a health maintenance organization. Qual Life Res (1992) 0.92
Phosphorylation cascades control the actions of ethanol on cell cAMP signalling. J Biomed Sci (2001) 0.92
Dental caries in HIV-seropositive women. J Dent Res (2004) 0.92
Endothelial cell damage and thrombosis following partial coronary arterial constriction: relevance to the pathogenesis of myocardial infarction. Isr J Med Sci (1978) 0.91
Caveolar systems and sarcoplasmic reticulum in coronary smooth muscle cells of the mouse. J Ultrastruct Res (1979) 0.91
Spinal cord injury. The role of vascular damage in the pathogenesis of central hemorrhagic necrosis. Arch Neurol (1977) 0.90
Comparative pharmacokinetics of salicylate elimination in man and rats. J Pharmacol Exp Ther (1966) 0.90
Aminoglycoside ototoxicity. Am J Otolaryngol (1980) 0.89
Laboratory investigation of PRRS virus infection in three swine herds. J Vet Diagn Invest (1993) 0.89
Scanning electron microscopic observations on the luminal surface of the rabbit common carotid artery subjected to ischemia by arterial occlusion. Stroke (1975) 0.89
Single daily dose therapy with aminoglycosides. J Hosp Infect (1991) 0.89
Comparative pharmacokinetics of coumarin anticoagulants. I. Unusual interaction of bishydroxycoumarin with plasma proteins--development of a new assay. J Pharm Sci (1968) 0.89
Central nervous system manifestations of penicillin toxicity in man. Neurology (1966) 0.89
Three-color flow cytometric assay for the study of the mechanisms of cell-mediated cytotoxicity. Immunol Lett (2001) 0.89
Pharmacokinetics of erythromycin in normal and alcoholic liver disease subjects. J Clin Pharmacol (1982) 0.88
Endothelial cell damage by temporary arterial occlusion with surgical clips. Study of the clip site by scanning and transmission electron microscopy. J Neurosurg (1976) 0.88
Ultrastructure of pericytes in mouse heart. Am J Anat (1977) 0.87
Schooling behavior of tadpoles: a potential indicator of ototoxicity. Pharmacol Biochem Behav (1982) 0.87
Squamous cell carcinoma of the prostate: a transformation from adenocarcinoma after the use of a luteinizing hormone-releasing hormone agonist and flutamide. Urology (1995) 0.87
TGF-beta1-enhanced TCP-coated sensate scaffolds can detect bone bonding. J Biomed Mater Res B Appl Biomater (2005) 0.87
Construction of a full-length Ca2+-sensitive adenylyl cyclase/aequorin chimera. J Biol Chem (1997) 0.87