Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40).

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28515429)

Published in Sci Rep on May 17, 2017

Authors

Emelie Wesén1, Gavin D M Jeffries2, Maria Matson Dzebo1,2, Elin K Esbjörner3

Author Affiliations

1: Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, 412 96, Gothenburg, Sweden.
2: Division of Chemistry and Biochemistry, Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Kemivägen 10, 412 96, Gothenburg, Sweden.
3: Division of Chemical Biology, Department of Biology and Biological Engineering, Chalmers University of Technology , Kemivägen 10, 412 96 Gothenburg, Sweden.

Articles cited by this

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51

Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87

Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07

A guided tour into subcellular colocalization analysis in light microscopy. J Microsc (2006) 16.73

Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A (1985) 16.10

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature (1995) 13.80

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation. J Cell Biol (1994) 11.55

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A (1986) 10.13

Mechanisms of endocytosis. Annu Rev Biochem (2009) 10.07

Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun (1984) 8.14

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet (2005) 7.66

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry (1993) 7.26

Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline. JAMA (2000) 6.55

Pathways of clathrin-independent endocytosis. Nat Rev Mol Cell Biol (2007) 6.48

Mechanism of action of cytochalasin B on actin. Cell (1980) 6.02

Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci (2007) 5.72

Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci (1991) 5.71

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation. J Cell Biol (1993) 5.62

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J (1993) 5.53

Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes. Science (2001) 5.45

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci (2001) 5.29

Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem (1983) 4.55

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem (2002) 4.20

Tickets to ride: selecting cargo for clathrin-regulated internalization. Nat Rev Mol Cell Biol (2009) 3.98

An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94

Clathrin-independent pinocytosis is induced in cells overexpressing a temperature-sensitive mutant of dynamin. J Cell Biol (1995) 3.92

Intraneuronal Abeta42 accumulation in human brain. Am J Pathol (2000) 3.83

Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic. J Cell Biol (2001) 3.70

A three-dimensional human neural cell culture model of Alzheimer's disease. Nature (2014) 3.48

apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain. J Clin Invest (2008) 3.36

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A (2011) 3.23

The coated pit and macropinocytic pathways serve distinct endosome populations. J Cell Biol (1994) 3.09

Actin assembly plays a variable, but not obligatory role in receptor-mediated endocytosis in mammalian cells. Traffic (2000) 2.63

Use of dynasore, the small molecule inhibitor of dynamin, in the regulation of endocytosis. Methods Enzymol (2008) 2.61

Defining macropinocytosis. Traffic (2009) 2.56

Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosis. J Neurosci (2009) 2.20

The role of A beta 42 in Alzheimer's disease. J Physiol Paris (1999) 2.14

Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide. Proc Natl Acad Sci U S A (2009) 2.14

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases. Neurobiol Aging (2005) 2.08

ATP is required for receptor-mediated endocytosis in intact cells. J Cell Biol (1990) 1.97

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci (2004) 1.92

Extracellular acidification alters lysosomal trafficking in human breast cancer cells. Neoplasia (2004) 1.70

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A (2011) 1.60

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell (2016) 1.60

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol Aging (2006) 1.55

Direct observations of amyloid β self-assembly in live cells provide insights into differences in the kinetics of Aβ(1-40) and Aβ(1-42) aggregation. Chem Biol (2014) 1.53

Temperature dependence of endocytosis mediated by the asialoglycoprotein receptor in isolated rat hepatocytes. Evidence for two potentially rate-limiting steps. J Biol Chem (1981) 1.46

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity. Proc Natl Acad Sci U S A (2010) 1.42

Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis (2010) 1.33

Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A beta 1-42, in differentiated PC12 cells. Brain Res (1997) 1.23

Abeta peptides can enter the brain through a defective blood-brain barrier and bind selectively to neurons. Brain Res (2007) 1.18

Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain. J Neurochem (2003) 1.13

Stimulated endocytosis in penetratin uptake: effect of arginine and lysine. Biochem Biophys Res Commun (2008) 1.10

Mechanism of neuronal versus endothelial cell uptake of Alzheimer's disease amyloid beta protein. PLoS One (2009) 1.10

Cellular mechanisms of protein aggregate propagation. Curr Opin Neurol (2012) 1.01

Dynasore - not just a dynamin inhibitor. Cell Commun Signal (2015) 0.92

β-Amyloid (1-40) peptide interactions with supported phospholipid membranes: a single-molecule study. Biophys J (2012) 0.92

Particle tracking of intracellular trafficking of octaarginine-modified liposomes: a comparative study with adenovirus. Mol Ther (2010) 0.91

Mechanisms of amyloid-Beta Peptide uptake by neurons: the role of lipid rafts and lipid raft-associated proteins. Int J Alzheimers Dis (2010) 0.89

The effect of the size of fluorescent dextran on its endocytic pathway. Cell Biol Int (2015) 0.86

The temperature effect during pulse application on cell membrane fluidity and permeabilization. Bioelectrochemistry (2008) 0.85

The role of macropinocytosis in the propagation of protein aggregation associated with neurodegenerative diseases. Front Physiol (2015) 0.83

Differences in the cellular uptake and intracellular itineraries of amyloid beta proteins 40 and 42: ramifications for the Alzheimer's drug discovery. Mol Pharm (2012) 0.82

Detection of amyloid-β fibrils using the DNA-intercalating dye YOYO-1: Binding mode and fibril formation kinetics. Biochem Biophys Res Commun (2015) 0.76