Published in Curr Opin Neurol on December 01, 2012
Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature (2013) 3.55
Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron (2014) 2.83
Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc Natl Acad Sci U S A (2013) 2.27
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat Immunol (2014) 1.83
Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nat Rev Neurosci (2015) 1.53
Neuronal aggregates: formation, clearance, and spreading. Dev Cell (2015) 1.09
Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimers Res Ther (2013) 1.00
Heterogeneous seeding of a prion structure by a generic amyloid form of the fungal prion-forming domain HET-s(218-289). J Biol Chem (2013) 0.92
Prions and Protein Assemblies that Convey Biological Information in Health and Disease. Neuron (2016) 0.87
Protease-sensitive prions with 144-bp insertion mutations. Aging (Albany NY) (2013) 0.84
Structural studies of truncated forms of the prion protein PrP. Biophys J (2015) 0.81
Ataxin-1 oligomers induce local spread of pathology and decreasing them by passive immunization slows Spinocerebellar ataxia type 1 phenotypes. Elife (2015) 0.77
Endocytic uptake of monomeric amyloid-β peptides is clathrin- and dynamin-independent and results in selective accumulation of Aβ(1-42) compared to Aβ(1-40). Sci Rep (2017) 0.75
Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry. J Vis Exp (2015) 0.75
Possible Function of Molecular Chaperones in Diseases Caused by Propagating Amyloid Aggregates. Front Neurosci (2017) 0.75
Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (1991) 49.03
Aggresomes: a cellular response to misfolded proteins. J Cell Biol (1998) 11.24
Eight prion strains have PrP(Sc) molecules with different conformations. Nat Med (1998) 9.01
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science (2005) 8.86
Transmission and spreading of tauopathy in transgenic mouse brain. Nat Cell Biol (2009) 7.50
Synthetic mammalian prions. Science (2004) 7.35
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation. Nat Med (2008) 6.90
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A (2009) 6.87
Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease. Nat Med (2008) 6.86
Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiol Aging (1995) 6.86
Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity. Science (1996) 6.71
Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science (2006) 6.47
Propagation of tau pathology in a model of early Alzheimer's disease. Neuron (2012) 6.23
Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem (2009) 5.76
Shattuck lecture--neurodegenerative diseases and prions. N Engl J Med (2001) 4.75
Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron (2011) 4.74
Trans-synaptic spread of tau pathology in vivo. PLoS One (2012) 4.53
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. J Exp Med (2012) 3.98
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J Neurosci (2010) 3.81
Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol (2011) 3.69
Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease. J Biol Chem (2011) 3.57
Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol (2009) 3.55
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. J Clin Invest (2011) 3.53
Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells. Proc Natl Acad Sci U S A (2011) 3.23
Recombinant prion protein induces a new transmissible prion disease in wild-type animals. Acta Neuropathol (2010) 3.19
Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein. Int J Biochem Cell Biol (2008) 2.78
Continuum of prion protein structures enciphers a multitude of prion isolate-specified phenotypes. Proc Natl Acad Sci U S A (2006) 2.69
Adenovirus triggers macropinocytosis and endosomal leakage together with its clathrin-mediated uptake. J Cell Biol (2002) 2.64
Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem (2012) 2.42
Purified and synthetic Alzheimer's amyloid beta (Aβ) prions. Proc Natl Acad Sci U S A (2012) 2.36
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem (2008) 2.34
Prion-like acceleration of a synucleinopathy in a transgenic mouse model. Neurobiol Aging (2011) 2.18
Strategy for nonenveloped virus entry: a hydrophobic conformer of the reovirus membrane penetration protein micro 1 mediates membrane disruption. J Virol (2002) 2.02
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
pH-dependent lysis of liposomes by adenovirus. Biochemistry (1986) 1.74
A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions. J Biol Chem (2011) 1.48
Some speculations about prions, amyloid, and Alzheimer's disease. N Engl J Med (1984) 1.35
Evidence for and against the transmissibility of Alzheimer disease. Neurology (1980) 1.34
Heparan sulfate is a cellular receptor for purified infectious prions. J Biol Chem (2005) 1.32
Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy. Mol Neurobiol (1994) 1.31
Conversion of wild-type alpha-synuclein into mutant-type fibrils and its propagation in the presence of A30P mutant. J Biol Chem (2009) 1.29
Heparan sulphate proteoglycan and the low-density lipoprotein receptor-related protein 1 constitute major pathways for neuronal amyloid-beta uptake. J Neurosci (2011) 1.28
Very long term studies of the seeding of beta-amyloidosis in primates. J Neural Transm (Vienna) (2005) 1.26
Paired helical filaments from Alzheimer disease brain induce intracellular accumulation of Tau protein in aggresomes. J Biol Chem (2012) 1.22
Constitutive secretion of tau protein by an unconventional mechanism. Neurobiol Dis (2012) 1.20
The 37-kDa/67-kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes. J Infect Dis (2006) 1.20
Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles. FEBS Lett (2011) 1.17
Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo. PLoS One (2012) 1.15
Cell-penetrating peptide induces leaky fusion of liposomes containing late endosome-specific anionic lipid. Biophys J (2010) 1.10
Hyperphosphorylation and cleavage at D421 enhance tau secretion. PLoS One (2012) 1.06
Accumulation of vesicle-associated human tau in distal dendrites drives degeneration and tau secretion in an in situ cellular tauopathy model. Int J Alzheimers Dis (2012) 1.02
Fibrillar structure and charge determine the interaction of polyglutamine protein aggregates with the cell surface. J Biol Chem (2012) 0.89
Propagation of tau misfolding from the outside to the inside of a cell. J Biol Chem (2009) 5.76
Prion-like mechanisms in neurodegenerative diseases. Nat Rev Neurosci (2009) 3.68
Trans-cellular propagation of Tau aggregation by fibrillar species. J Biol Chem (2012) 2.42
Conformational diversity of wild-type Tau fibrils specified by templated conformation change. J Biol Chem (2008) 2.34
In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. J Neurosci (2011) 2.00
Polyglutamine diseases: emerging concepts in pathogenesis and therapy. Hum Mol Genet (2007) 1.95
The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A (2005) 1.89
Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds. Proc Natl Acad Sci U S A (2013) 1.88
Mechanisms of protein seeding in neurodegenerative diseases. JAMA Neurol (2013) 1.51
Interaction with polyglutamine aggregates reveals a Q/N-rich domain in TDP-43. J Biol Chem (2010) 1.47
A rapid cellular FRET assay of polyglutamine aggregation identifies a novel inhibitor. Neuron (2003) 1.45
Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy. J Biol Chem (2006) 1.41
Non-competitive androgen receptor inhibition in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 1.37
Phosphorylation of profilin by ROCK1 regulates polyglutamine aggregation. Mol Cell Biol (2008) 1.35
Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Neurobiol Dis (2009) 1.16
Biologically active molecules that reduce polyglutamine aggregation and toxicity. Hum Mol Genet (2006) 1.14
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology (2006) 1.04
A cellular conformation-based screen for androgen receptor inhibitors. ACS Chem Biol (2008) 1.03
Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet (2013) 0.99
An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. J Biol Chem (2013) 0.99
ROCK and PRK-2 mediate the inhibitory effect of Y-27632 on polyglutamine aggregation. FEBS Lett (2008) 0.98
Huntington disease and the huntingtin protein. Prog Mol Biol Transl Sci (2012) 0.95
Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening. Proc Natl Acad Sci U S A (2009) 0.93
A common motif targets huntingtin and the androgen receptor to the proteasome. J Biol Chem (2008) 0.92
F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics. PLoS One (2010) 0.90
AR inhibitors identified by high-throughput microscopy detection of conformational change and subcellular localization. ACS Chem Biol (2009) 0.90
Design and implementation of cell-based assays to model human disease. ACS Chem Biol (2007) 0.89
Prion-like propagation of protein aggregation and related therapeutic strategies. Neurotherapeutics (2013) 0.88
The expanding realm of prion phenomena in neurodegenerative disease. Prion (2009) 0.86
Intravitreal administration of HA-1077, a ROCK inhibitor, improves retinal function in a mouse model of huntington disease. PLoS One (2013) 0.86
An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet (2011) 0.84
Amyotrophic lateral sclerosis and organ donation: is there risk of disease transmission? Ann Neurol (2012) 0.79
Advances in diagnostic testing for Alzheimer disease. Mo Med (2013) 0.78
Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. PLoS One (2012) 0.77
A strong consensus has emerged around the role of protein misfolding and aggregation in the pathogenesis of neurodegeneration. Introduction. Neurotherapeutics (2013) 0.75