Published in Heliyon on June 09, 2017
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Protein kinase CK2 and its role in cellular proliferation, development and pathology. Electrophoresis (1999) 2.16
CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy. Cancer Res (2010) 2.06
Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality. Mol Cell Biol (2003) 1.85
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Protein kinase CK2 contributes to the organization of sodium channels in axonal membranes by regulating their interactions with ankyrin G. J Cell Biol (2008) 1.60
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron (2010) 1.55
Mitotic reorganization of the intermediate filament protein nestin involves phosphorylation by cdc2 kinase. J Biol Chem (2001) 1.31
Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. EMBO J (1993) 1.31
Protein kinase CK2 inhibitors: a patent review. Expert Opin Ther Pat (2012) 1.21
Ankyrin G restricts ion channel diffusion at the axonal initial segment before the establishment of the diffusion barrier. J Cell Biol (2010) 1.18
Protein kinase CK2 as a druggable target. Mol Biosyst (2008) 1.16
Advances in kinase targeting: current clinical use and clinical trials. Trends Pharmacol Sci (2014) 1.13
Gene targeting of CK2 catalytic subunits. Mol Cell Biochem (2008) 1.12
Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer. Mol Cell Biochem (2011) 1.12
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling. Leukemia (2013) 1.02
Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2. Biochem J (2009) 1.02
Structural basis of CX-4945 binding to human protein kinase CK2. FEBS Lett (2010) 0.97
New protein kinase CK2 inhibitors: jumping out of the catalytic box. Chem Biol (2009) 0.96
CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research. Mol Cell Biochem (2011) 0.95
Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon. Mol Cell Biol (2010) 0.93
Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry (2011) 0.91
In vivo functional analysis of Drosophila protein kinase casein kinase 2 (CK2) beta-subunit. Gene (2002) 0.90
Identification of a novel function of CX-4945 as a splicing regulator. PLoS One (2014) 0.89
Protein kinase CK2 and angiogenesis. Adv Clin Exp Med (2014) 0.88
Localization of CKII beta subunits in Lewy bodies of Parkinson's disease. J Neurol Sci (2007) 0.87
Phosphorylation of microtubule-associated proteins by protein kinase CK2 in neuritogenesis. Cell Mol Biol Res (1994) 0.87
Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells. Oncotarget (2014) 0.84
Changes in protein kinases in brain aging and Alzheimer's disease. Implications for drug therapy. Drugs Aging (1995) 0.83
Protein kinase CK2 is implicated in early steps of the differentiation of pre-adipocytes into adipocytes. Mol Cell Biochem (2012) 0.82
Casein kinase 2α regulates glioblastoma brain tumor-initiating cell growth through the β-catenin pathway. Oncogene (2014) 0.82
Protein kinase CK2 is a regulator of angiogenesis in endometriotic lesions. Angiogenesis (2012) 0.82
Amyloid beta-protein stimulates casein kinase I and casein kinase II activities. Brain Res (1993) 0.82
Drosophila mbm is a nucleolar myc and casein kinase 2 target required for ribosome biogenesis and cell growth of central brain neuroblasts. Mol Cell Biol (2014) 0.82
Glia-neuron interactions in nervous system function and development. Curr Top Dev Biol (2005) 0.81
Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells. Biochim Biophys Acta (2015) 0.81
The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro. Mol Cells (2013) 0.80
The Selectivity of CK2 Inhibitor Quinalizarin: A Reevaluation. Biomed Res Int (2015) 0.78
Increase in cytoplasmic casein kinase II-type activity accompanies neurite outgrowth after DNA synthesis inhibition in NIA-103 neuroblastoma cells. J Neurochem (1992) 0.78
Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. J Cell Biol (2014) 0.77
Regulation of protein kinase CK2 isoform expression during rat brain development. Cell Mol Biol Res (1994) 0.77
Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell. Mol Cell Biochem (2011) 0.76