Published in Int J Mol Sci on July 01, 2017
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
Autophagy: process and function. Genes Dev (2007) 15.21
Autophagy in human health and disease. N Engl J Med (2013) 8.71
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) (1975) 4.37
Autophagy: cellular and molecular mechanisms. J Pathol (2010) 3.96
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol (2012) 2.91
Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol (2007) 2.70
Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem Pharmacol (1990) 2.60
Integrated approaches towards drug development from Ayurveda and other Indian system of medicines. J Ethnopharmacol (2005) 1.84
Autophagy as a therapeutic target in cancer. Cancer Biol Ther (2011) 1.84
Autophagy and cancer. Exp Mol Med (2012) 1.57
MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin. Oncotarget (2014) 1.36
Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLoS One (2011) 1.27
Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90. J Cell Physiol (2012) 1.25
Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy. Cell Death Dis (2010) 1.13
The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation. Autophagy (2014) 1.06
Alisol B, a novel inhibitor of the sarcoplasmic/endoplasmic reticulum Ca(2+) ATPase pump, induces autophagy, endoplasmic reticulum stress, and apoptosis. Mol Cancer Ther (2010) 1.05
New insights on the antitumoral properties of prodiginines. Curr Med Chem (2010) 1.03
Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53. Cancer Res (2013) 1.02
The chemistry, pharmacologic, and therapeutic applications of Polyalthia longifolia. Pharmacogn Rev (2010) 1.02
Antimicrobial activity of clerodane diterpenoids from Polyalthia longifolia seeds. Fitoterapia (2005) 1.01
Curcumin promotes differentiation of glioma-initiating cells by inducing autophagy. Cancer Sci (2012) 0.97
Autophagy triggered by magnolol derivative negatively regulates angiogenesis. Cell Death Dis (2013) 0.96
Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases. Carcinogenesis (2012) 0.96
Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization. Oncotarget (2015) 0.95
Ursolic acid induces cell death and modulates autophagy through JNK pathway in apoptosis-resistant colorectal cancer cells. J Nutr Biochem (2012) 0.95
Resveratrol inhibits breast cancer stem-like cells and induces autophagy via suppressing Wnt/β-catenin signaling pathway. PLoS One (2014) 0.94
Gossypol and an HMT G9a inhibitor act in synergy to induce cell death in pancreatic cancer cells. Cell Death Dis (2013) 0.93
Anti-inflammatory and cytotoxic diterpenes from formosan Polyalthia longifolia var. pendula. Planta Med (2006) 0.93
Cytotoxic effect of evodiamine in SGC-7901 human gastric adenocarcinoma cells via simultaneous induction of apoptosis and autophagy. Oncol Rep (2012) 0.91
Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways. Int J Oncol (2011) 0.91
Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin. Cell Death Dis (2015) 0.90
Antimalarial activity of natural and synthetic prodiginines. J Med Chem (2011) 0.89
Butyl-meta-cycloheptylprodiginine--a revision of the structure of the former ortho-isomer. J Antibiot (Tokyo) (1991) 0.89
Neoalbaconol induces energy depletion and multiple cell death in cancer cells by targeting PDK1-PI3-K/Akt signaling pathway. Cell Death Dis (2013) 0.89
Development of natural anti-tumor drugs by microorganisms. J Biosci Bioeng (2011) 0.88
Selective targeting of breast cancer cells through ROS-mediated mechanisms potentiates the lethality of paclitaxel by a novel diterpene, gelomulide K. Free Radic Biol Med (2011) 0.88
Cryptotanshinone induces G1 cell cycle arrest and autophagic cell death by activating the AMP-activated protein kinase signal pathway in HepG2 hepatoma. Apoptosis (2014) 0.88
Tanshinone IIA induces autophagic cell death via activation of AMPK and ERK and inhibition of mTOR and p70 S6K in KBM-5 leukemia cells. Phytother Res (2013) 0.86
Alternative Pathways of Cancer Cell Death by Rottlerin: Apoptosis versus Autophagy. Evid Based Complement Alternat Med (2012) 0.84
Curcumin induces cross-regulation between autophagy and apoptosis in uterine leiomyosarcoma cells. Int J Gynecol Cancer (2013) 0.84
Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy. J Exp Clin Cancer Res (2014) 0.84
Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors. PLoS One (2013) 0.84
Prodigiosin inhibits gp91(phox) and iNOS expression to protect mice against the oxidative/nitrosative brain injury induced by hypoxia-ischemia. Toxicol Appl Pharmacol (2011) 0.84
Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family members. PLoS One (2013) 0.83
In vitro changes in mitochondrial potential, aggresome formation and caspase activity by a novel 17-β-estradiol analogue in breast adenocarcinoma cells. Cell Biochem Funct (2013) 0.83
Resveratrol triggers protective autophagy through the ceramide/Akt/mTOR pathway in melanoma B16 cells. Nutr Cancer (2014) 0.83
Honokiol induces cytotoxic and cytostatic effects in malignant melanoma cancer cells. Am J Surg (2012) 0.83
Guttiferone K induces autophagy and sensitizes cancer cells to nutrient stress-induced cell death. Phytomedicine (2015) 0.83
Antimicrobial activity of prodigiosin isolated from Serratia marcescens UFPEDA 398. World J Microbiol Biotechnol (2014) 0.82
Induction of autophagy by dimethyl cardamonin is associated with proliferative arrest in human colorectal carcinoma HCT116 and LOVO cells. J Cell Biochem (2011) 0.82
(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death. Drug Des Devel Ther (2013) 0.82
16-hydroxycleroda-3,13-dien-15,16-olide regulates the expression of histone-modifying enzymes PRC2 complex and induces apoptosis in CML K562 cells. Life Sci (2011) 0.81
Cytotoxic and antibacterial angucycline- and prodigiosin-analogues from the deep-sea derived Streptomyces sp. SCSIO 11594. Mar Drugs (2015) 0.81
The synthetic β-nitrostyrene derivative CYT-Rx20 induces breast cancer cell death and autophagy via ROS-mediated MEK/ERK pathway. Cancer Lett (2015) 0.81
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Toxicol Appl Pharmacol (2012) 0.81
Resveratrol-induced autophagy in human U373 glioma cells. Oncol Lett (2010) 0.81
Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells. Autophagy (2015) 0.81
Stimulation of autophagic activity in human glioma cells by anti-proliferative ardipusilloside I isolated from Ardisia pusilla. Life Sci (2014) 0.81
Cytotoxicity of goniothalamin enantiomers in renal cancer cells: involvement of nitric oxide, apoptosis and autophagy. Chem Biol Interact (2008) 0.80
Increase of autophagy and attenuation of apoptosis by Salvigenin promote survival of SH-SY5Y cells following treatment with H₂O₂. Mol Cell Biochem (2012) 0.80
Gossypol enhances radiation induced autophagy in glioblastoma multiforme. Gen Physiol Biophys (2014) 0.80
Effect of new berberine derivatives on colon cancer cells. Acta Biochim Biophys Sin (Shanghai) (2015) 0.80
NF-κB p65 repression by the sesquiterpene lactone, Helenalin, contributes to the induction of autophagy cell death. BMC Complement Altern Med (2012) 0.80
Elevated survivin mediated multidrug resistance and reduced apoptosis in breast cancer stem cells. J BUON (2015) 0.80
16-Hydroxycleroda-3,13-dien-15,16-olide deregulates PI3K and Aurora B activities that involve in cancer cell apoptosis. Toxicology (2011) 0.79
Prodigiosin isolated from cell wall of Serratia marcescens alters expression of apoptosis-related genes and increases apoptosis in colorectal cancer cells. Med Oncol (2014) 0.79
A novel inhibitor, 16-hydroxy-cleroda-3,13-dien-16,15-olide, blocks the autophosphorylation site of focal adhesion kinase (Y397) by molecular docking. Biochim Biophys Acta (2013) 0.79
Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells. J Nat Med (2015) 0.79
Effective Targeting Survivin, Caspase-3 and MicroRNA-16-1 Expression by Methyl-3-pentyl-6-methoxyprodigiosene Triggers Apoptosis in Colorectal Cancer Stem-Like Cells. Pathol Oncol Res (2016) 0.79
Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives - A review. J Tradit Complement Med (2016) 0.79
Betanin-Enriched Red Beetroot (Beta vulgaris L.) Extract Induces Apoptosis and Autophagic Cell Death in MCF-7 Cells. Phytother Res (2015) 0.79
Serratia Secondary Metabolite Prodigiosin Inhibits Pseudomonas aeruginosa Biofilm Development by Producing Reactive Oxygen Species that Damage Biological Molecules. Front Microbiol (2016) 0.79
Sirolimus and Everolimus Pathway: Reviewing Candidate Genes Influencing Their Intracellular Effects. Int J Mol Sci (2016) 0.78
Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells. J Drug Target (2016) 0.78
Honokiol inhibits melanoma stem cells by targeting notch signaling. Mol Carcinog (2014) 0.78
Autophagy inhibition enhances isobavachalcone-induced cell death in multiple myeloma cells. Int J Mol Med (2012) 0.78
Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization. J Org Chem (2014) 0.78
Oridonin induces autophagy via inhibition of glucose metabolism in p53-mutated colorectal cancer cells. Cell Death Dis (2017) 0.77
A triterpenoid saponin from Adenophora triphylla var. japonica suppresses the growth of human gastric cancer cells via regulation of apoptosis and autophagy. Tumour Biol (2014) 0.77
The marine triterpene glycoside frondoside A induces p53-independent apoptosis and inhibits autophagy in urothelial carcinoma cells. BMC Cancer (2017) 0.77
A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Invest New Drugs (2011) 0.77
16-hydroxy-cleroda-3,13-dien-16,15-olide induced glioma cell autophagy via ROS generation and activation of p38 MAPK and ERK-1/2. Environ Toxicol Pharmacol (2016) 0.77
Synthesis and antimalarial activity of prodigiosenes. Org Biomol Chem (2014) 0.77
Novel curcumin analogue IHCH exhibits potent anti‑proliferative effects by inducing autophagy in A549 lung cancer cells. Mol Med Rep (2014) 0.77
Cytotoxic prodigiosin family pigments from Pseudoalteromonas sp. 1020R isolated from the Pacific coast of Japan. Biosci Biotechnol Biochem (2012) 0.77
Lipoic acid inhibits the DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) and triggers its depletion in colorectal cancer cells with concomitant autophagy induction. Carcinogenesis (2015) 0.77
Prodigiosin, the red pigment of Serratia marcescens, shows cytotoxic effects and apoptosis induction in HT-29 and T47D cancer cell lines. Nat Prod Res (2011) 0.76
Antitumor Activity of Spicatoside A by Modulation of Autophagy and Apoptosis in Human Colorectal Cancer Cells. J Nat Prod (2016) 0.76
Enhancement of apoptotic and autophagic induction by a novel synthetic C-1 analogue of 7-deoxypancratistatin in human breast adenocarcinoma and neuroblastoma cells with tamoxifen. J Vis Exp (2012) 0.76
Dual targeted therapy with p53 siRNA and Epigallocatechingallate in a triple negative breast cancer cell model. PLoS One (2015) 0.76
Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother (2016) 0.76
In -silico molecular docking analysis of prodigiosin and cycloprodigiosin as COX-2 inhibitors. Springerplus (2013) 0.76
Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insult. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.76
Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer. Oncotarget (2016) 0.76
Autophagy antagonizes apoptosis induced by flavan enantiomers from Daphne giraldii in hepatic carcinoma cells in vitro. Eur J Med Chem (2017) 0.76
Anti-tumor activity evaluation of novel chrysin-organotin compound in MCF-7 cells. Bioorg Med Chem Lett (2015) 0.76