Published in Int J Mol Sci on July 10, 2017
Chromatin modifications and their function. Cell (2007) 55.98
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature (2006) 27.91
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature (2003) 20.13
The DNA-damage response in human biology and disease. Nature (2009) 17.86
The DNA damage response: making it safe to play with knives. Mol Cell (2010) 16.13
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. Cell (2001) 11.39
Beyond the sequence: cellular organization of genome function. Cell (2007) 10.32
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell (2006) 8.12
RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. Science (2007) 6.70
Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation. Cell (2005) 6.17
The multifaceted mismatch-repair system. Nat Rev Mol Cell Biol (2006) 6.16
Playing the end game: DNA double-strand break repair pathway choice. Mol Cell (2012) 5.42
Transcription elongation factors repress transcription initiation from cryptic sites. Science (2003) 5.18
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol (2005) 5.11
Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell (1988) 5.09
Nucleosome loss activates yeast downstream promoters in vivo. Cell (1988) 4.69
Regulation of homologous recombination in eukaryotes. Annu Rev Genet (2010) 4.33
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol (2007) 4.14
Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature (2012) 3.92
The nucleosome: from genomic organization to genomic regulation. Cell (2004) 3.83
Human mutation rate associated with DNA replication timing. Nat Genet (2009) 3.81
H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol (2006) 3.73
R loops: from transcription byproducts to threats to genome stability. Mol Cell (2012) 3.71
Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair (Amst) (2006) 3.61
The connection between transcription and genomic instability. EMBO J (2002) 3.44
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Mol Cell (2006) 3.39
BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation. Nat Struct Mol Biol (2009) 3.26
Acetylation limits 53BP1 association with damaged chromatin to promote homologous recombination. Nat Struct Mol Biol (2013) 3.18
Activation of the cellular DNA damage response in the absence of DNA lesions. Science (2008) 3.17
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev (2008) 3.16
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature (2008) 3.14
Endogenous DNA damage in humans: a review of quantitative data. Mutagenesis (2004) 3.02
Facultative heterochromatin: is there a distinctive molecular signature? Mol Cell (2007) 2.94
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome. EMBO J (2010) 2.89
The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro. Cell (1986) 2.88
53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat Cell Biol (2010) 2.88
An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. Nat Genet (2002) 2.87
Asf1 mediates histone eviction and deposition during elongation by RNA polymerase II. Mol Cell (2006) 2.71
Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nat Cell Biol (2011) 2.69
Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals. J Cell Biol (2007) 2.55
Higher-order structures of chromatin: the elusive 30 nm fiber. Cell (2007) 2.45
Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol (2009) 2.40
Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol (2007) 2.40
Repair of endogenous DNA damage. Cold Spring Harb Symp Quant Biol (2000) 2.24
Cotranscriptional processes and their influence on genome stability. Genes Dev (2006) 2.23
Chromatin remodeling at DNA double-strand breaks. Cell (2013) 2.18
Topologically associating domains are stable units of replication-timing regulation. Nature (2014) 2.17
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature (2013) 2.17
New insights into nucleosome and chromatin structure: an ordered state or a disordered affair? Nat Rev Mol Cell Biol (2012) 2.14
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol Cell (2011) 2.13
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
Prime, repair, restore: the active role of chromatin in the DNA damage response. Mol Cell (2012) 2.04
Histone exchange, chromatin structure and the regulation of transcription. Nat Rev Mol Cell Biol (2015) 2.02
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage. EMBO J (2003) 1.97
KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle (2008) 1.90
Chromatin higher-order structure and dynamics. Cold Spring Harb Perspect Biol (2010) 1.81
Epigenetic regulation of heterochromatic DNA stability. Curr Opin Genet Dev (2008) 1.80
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol (2011) 1.77
Nucleotide excision repair in eukaryotes. Cold Spring Harb Perspect Biol (2013) 1.72
Chromatin and the genome integrity network. Nat Rev Genet (2013) 1.72
Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Mol Cell (2012) 1.63
Heterochromatin function in complex genomes. Biochim Biophys Acta (2000) 1.58
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep (2014) 1.57
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity. Nucleic Acids Res (2013) 1.55
Transcription-replication encounters, consequences and genomic instability. Nat Struct Mol Biol (2013) 1.54
Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo. Cell (2015) 1.53
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A (2014) 1.51
A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. Cell Rep (2014) 1.49
Nucleosome rearrangement in human chromatin during UV-induced DNA- reapir synthesis. Proc Natl Acad Sci U S A (1978) 1.46
Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption. Mol Cell Biol (2012) 1.45
A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression. Genes Dev (2014) 1.45
Histone degradation in response to DNA damage enhances chromatin dynamics and recombination rates. Nat Struct Mol Biol (2017) 1.45
RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNA. Biochim Biophys Acta (2006) 1.35
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation. J Cell Biol (2011) 1.34
Differential DNA mismatch repair underlies mutation rate variation across the human genome. Nature (2015) 1.34
Endogenous DNA damage and mutation. Trends Genet (2001) 1.34
The topography of mutational processes in breast cancer genomes. Nat Commun (2016) 1.30
Suv39h-dependent H3K9me3 marks intact retrotransposons and silences LINE elements in mouse embryonic stem cells. Mol Cell (2014) 1.28
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells. Genes Dev (2014) 1.23
Chromatin and DNA replication. Cold Spring Harb Perspect Biol (2013) 1.22
Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair. Nat Biotechnol (2013) 1.21
Protection of repetitive DNA borders from self-induced meiotic instability. Nature (2011) 1.20
DNA replication origin activation in space and time. Nat Rev Mol Cell Biol (2015) 1.20
Heterochromatin and the DNA damage response: the need to relax. Biochem Cell Biol (2011) 1.20
Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes. Nature (2016) 1.16
Nucleotide excision repair is impaired by binding of transcription factors to DNA. Nature (2016) 1.15
The chromatin remodeler p400 ATPase facilitates Rad51-mediated repair of DNA double-strand breaks. J Cell Biol (2012) 1.15
Chromatin structure influences the sensitivity of DNA to gamma-radiation. Biochim Biophys Acta (2008) 1.15
Activation of DNA damage response signaling by condensed chromatin. Cell Rep (2014) 1.14
Pathway choice in DNA double strand break repair: observations of a balancing act. Genome Integr (2012) 1.13
Chromatin and the DNA damage response: the cancer connection. Mol Oncol (2011) 1.12
HP1 promotes tumor suppressor BRCA1 functions during the DNA damage response. Nucleic Acids Res (2013) 1.11