Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair.

Hypermutation in human cancer genomes: footprints and mechanisms. Nat Rev Cancer (2014) 1.67

Genome-wide patterns and properties of de novo mutations in humans. Nat Genet (2015) 1.65

Differential DNA repair underlies mutation hotspots at active promoters in cancer genomes. Nature (2016) 1.16

Nucleotide excision repair is impaired by binding of transcription factors to DNA. Nature (2016) 1.15

Mutational Strand Asymmetries in Cancer Genomes Reveal Mechanisms of DNA Damage and Repair. Cell (2016) 1.08

A Dual Model for Prioritizing Cancer Mutations in the Non-coding Genome Based on Germline and Somatic Events. PLoS Comput Biol (2015) 1.07

Retracted Mutation pattern is an influential factor on functional mutation rates in cancer. Cancer Cell Int (2016) 1.06

Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis. Proc Natl Acad Sci U S A (2016) 0.95

Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution. Proc Natl Acad Sci U S A (2016) 0.92

APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer. Cell Rep (2015) 0.88

Genomic approaches to DNA repair and mutagenesis. DNA Repair (Amst) (2015) 0.86

APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions. Cell Rep (2015) 0.85

The role of enhancers in cancer. Nat Rev Cancer (2016) 0.84

Transcription restores DNA repair to heterochromatin, determining regional mutation rates in cancer genomes. Cell Rep (2014) 0.83

How the environment shapes cancer genomes. Curr Opin Oncol (2015) 0.80

Single-cell whole-genome analyses by Linear Amplification via Transposon Insertion (LIANTI). Science (2017) 0.79

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer. Nat Genet (2016) 0.79

UV-Induced DNA Damage and Mutagenesis in Chromatin. Photochem Photobiol (2016) 0.79

The search for cis-regulatory driver mutations in cancer genomes. Oncotarget (2015) 0.78

Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma. PLoS One (2015) 0.78

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies. Oncotarget (2016) 0.77

Network perturbation by recurrent regulatory variants in cancer. PLoS Comput Biol (2017) 0.75

Simulating Next-Generation Sequencing Datasets from Empirical Mutation and Sequencing Models. PLoS One (2016) 0.75

Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations. Cancer Discov (2016) 0.75

Cancer genomics: Hard-to-reach repairs. Nature (2016) 0.75

Chromatin Dynamics in Genome Stability: Roles in Suppressing Endogenous DNA Damage and Facilitating DNA Repair. Int J Mol Sci (2017) 0.75

Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk. Br J Cancer (2017) 0.75

KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res (2011) 30.20

A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27

Evolution at two levels in humans and chimpanzees. Science (1975) 21.07

Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature (2013) 20.16

A small-cell lung cancer genome with complex signatures of tobacco exposure. Nature (2009) 18.39

Initial genome sequencing and analysis of multiple myeloma. Nature (2011) 17.28

The accessible chromatin landscape of the human genome. Nature (2012) 16.86

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol (2013) 16.13

Nuclease hypersensitive sites in chromatin. Annu Rev Biochem (1988) 13.48

Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22

Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet (2010) 10.15

Mammalian DNA nucleotide excision repair reconstituted with purified protein components. Cell (1995) 9.53

A high-resolution map of human evolutionary constraint using 29 mammals. Nature (2011) 8.67

Highly recurrent TERT promoter mutations in human melanoma. Science (2013) 8.40

Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77

An expansive human regulatory lexicon encoded in transcription factor footprints. Nature (2012) 7.27

Transcription-coupled DNA repair: two decades of progress and surprises. Nat Rev Mol Cell Biol (2008) 7.00

8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. J Biol Chem (1992) 6.20

Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet (2011) 5.67

APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing. Proc Natl Acad Sci U S A (2009) 4.76

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell (2012) 4.52

Chromatin organization is a major influence on regional mutation rates in human cancer cells. Nature (2012) 3.92

Human mutation rate associated with DNA replication timing. Nat Genet (2009) 3.81

Determinants and dynamics of genome accessibility. Nat Rev Genet (2011) 3.15

Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites. Science (2008) 3.10

Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology. Cell Res (2008) 3.06

DNA polymerases and cancer. Nat Rev Cancer (2011) 3.05

The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair. DNA Repair (Amst) (2007) 2.26

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis. Biol Chem (2006) 2.07

Initiation of DNA repair mediated by a stalled RNA polymerase IIO. EMBO J (2006) 1.44

The large-scale distribution of somatic mutations in cancer genomes. Hum Mutat (2011) 1.32

Evolution of the deaminase fold and multiple origins of eukaryotic editing and mutagenic nucleic acid deaminases from bacterial toxin systems. Nucleic Acids Res (2011) 1.25

Functional characterization of global genomic DNA repair and its implications for cancer. Mutat Res (2003) 1.23

Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes. Science (2012) 1.22

Xeroderma pigmentosum genes: functions inside and outside DNA repair. Carcinogenesis (2008) 1.11

Repair of UV lesions in nucleosomes--intrinsic properties and remodeling. DNA Repair (Amst) (2005) 1.10

Oxidative stress triggers the preferential assembly of base excision repair complexes on open chromatin regions. Nucleic Acids Res (2010) 1.06

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. PLoS Biol (2011) 1.05

Open, repair and close again: chromatin dynamics and the response to UV-induced DNA damage. DNA Repair (Amst) (2010) 1.03

Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae. Biochimie (1997) 0.96

Clusters of S1 nuclease-hypersensitive sites induced in vivo by DNA damage. Mol Cell Biol (1997) 0.92

Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex. DNA Repair (Amst) (2005) 0.90

Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes. PLoS Genet (2012) 0.87

Chronic low-dose ultraviolet-induced mutagenesis in nucleotide excision repair-deficient cells. Nucleic Acids Res (2012) 0.78