Published in Trends Biochem Sci on July 19, 2017
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods (1995) 16.00
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol (2012) 7.32
Annexins: from structure to function. Physiol Rev (2002) 6.78
Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature (2001) 6.31
Annexins: linking Ca2+ signalling to membrane dynamics. Nat Rev Mol Cell Biol (2005) 5.71
TAM receptors are pleiotropic inhibitors of the innate immune response. Cell (2007) 5.32
Vaccinia virus uses macropinocytosis and apoptotic mimicry to enter host cells. Science (2008) 5.04
Inside-outside transitions of phospholipids in vesicle membranes. Biochemistry (1971) 4.84
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet (2000) 4.42
BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature (2007) 4.36
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell (2010) 4.30
Immunobiology of the TAM receptors. Nat Rev Immunol (2008) 4.26
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell (1995) 4.13
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet (2000) 3.72
Calcium-dependent phospholipid scrambling by TMEM16F. Nature (2010) 3.63
The distribution and function of phosphatidylserine in cellular membranes. Annu Rev Biophys (2010) 3.31
Phagocytosis promotes programmed cell death in C. elegans. Nature (2001) 3.12
Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature (1999) 2.80
TIM genes: a family of cell surface phosphatidylserine receptors that regulate innate and adaptive immunity. Immunol Rev (2010) 2.64
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegans. Nature (2001) 2.64
Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways. Immunity (2011) 2.47
Rapid cell corpse clearance by stabilin-2, a membrane phosphatidylserine receptor. Cell Death Differ (2007) 2.44
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature (2013) 2.43
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells. Cell Stem Cell (2016) 2.32
Tyro3 family-mediated cell entry of Ebola and Marburg viruses. J Virol (2006) 2.24
Diversification of TAM receptor tyrosine kinase function. Nat Immunol (2014) 2.12
X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature (2014) 2.04
The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry. Cell Host Microbe (2012) 2.03
Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science (2013) 1.98
TAM receptor function in the retinal pigment epithelium. Mol Cell Neurosci (2006) 1.96
Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood (1999) 1.91
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nat Commun (2013) 1.80
Microglial phagocytosis of live neurons. Nat Rev Neurosci (2014) 1.79
Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci U S A (2013) 1.78
The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer. Nat Rev Cancer (2014) 1.77
Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem (2013) 1.74
Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat Struct Biol (2003) 1.68
New roles for TIM family members in immune regulation. Nat Rev Immunol (2008) 1.68
Biology of the TAM receptors. Cold Spring Harb Perspect Biol (2013) 1.59
C1q binds phosphatidylserine and likely acts as a multiligand-bridging molecule in apoptotic cell recognition. J Immunol (2008) 1.59
Structural basis for Gas6-Axl signalling. EMBO J (2005) 1.56
Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science (2014) 1.52
The vitamin K cycle. J Thromb Haemost (2005) 1.49
Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J Clin Invest (2009) 1.47
Antigen recognition induces phosphatidylserine exposure on the cell surface of human CD8+ T cells. Blood (2006) 1.45
Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors. Cell Host Microbe (2013) 1.42
TAM receptors and the clearance of apoptotic cells. Ann N Y Acad Sci (2010) 1.39
Genetic dissection of TAM receptor-ligand interaction in retinal pigment epithelial cell phagocytosis. Neuron (2012) 1.23
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein. Virology (2011) 1.22
Vitamin K-dependent carboxylation. Vitam Horm (2008) 1.19
TAM receptor signaling in immune homeostasis. Annu Rev Immunol (2015) 1.18
Dynamic transbilayer lipid asymmetry. Cold Spring Harb Perspect Biol (2011) 1.18
T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity (2013) 1.14
Concepts and consequences of Eph receptor clustering. Semin Cell Dev Biol (2012) 1.13
Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics. Cell Rep (2016) 1.13
Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife (2014) 1.11
Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J Cell Sci (2009) 1.10
Role of complement and other innate immune mechanisms in the removal of apoptotic cells. Curr Dir Autoimmun (2006) 1.06
New insights on the role of microglia in synaptic pruning in health and disease. Curr Opin Neurobiol (2015) 1.06
The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. Nutr Neurosci (2001) 1.06
Receptor tyrosine kinases, TYRO3, AXL, and MER, demonstrate distinct patterns and complex regulation of ligand-induced activation. J Biol Chem (2014) 1.05
Annexins and endocytosis. Traffic (2007) 1.05
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nat Med (2015) 1.02
Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina. Proc Natl Acad Sci U S A (2012) 1.02
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer. Cell Death Differ (2016) 1.01
Recognition of phosphatidylserine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat. J Biol Chem (1997) 1.01
Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane. Physiol Rev (2016) 0.97
TAM receptors regulate multiple features of microglial physiology. Nature (2016) 0.97
Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification. Vitam Horm (2008) 0.96
An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Chem Biol (2014) 0.96
Selective recapture of secretory granule components after full collapse exocytosis in neuroendocrine chromaffin cells. Traffic (2010) 0.94
Phosphatidylserine receptors: enhancers of enveloped virus entry and infection. Virology (2014) 0.93
Vitamin K-dependent proteins in Ciona intestinalis, a basal chordate lacking a blood coagulation cascade. Proc Natl Acad Sci U S A (2006) 0.92
Monitoring apoptosis and neuronal degeneration by real-time detection of phosphatidylserine externalization using a polarity-sensitive indicator of viability and apoptosis. Nat Protoc (2010) 0.91
Contributions of Gla and EGF-like domains to the function of vitamin K-dependent coagulation factors. Crit Rev Eukaryot Gene Expr (1999) 0.90
A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature (2016) 0.90
Phospholipid scramblase-1-induced lipid reorganization regulates compensatory endocytosis in neuroendocrine cells. J Neurosci (2013) 0.89
Apoptotic cell recognition receptors and scavenger receptors. Immunol Rev (2016) 0.87
Structural and functional insights into human vitamin K epoxide reductase and vitamin K epoxide reductase-like1. Crit Rev Biochem Mol Biol (2013) 0.86
Exposure of phosphatidylserine on the cell surface. Cell Death Differ (2016) 0.86
The Axl receptor tyrosine kinase is a discriminator of macrophage function in the inflamed lung. Mucosal Immunol (2015) 0.86
Axl Mediates ZIKA Virus Entry in Human Glial Cells and Modulates Innate Immune Responses. Cell Rep (2017) 0.85
Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium. J Biol Chem (2015) 0.83
Roles and regulation of phospholipid scramblases. FEBS Lett (2014) 0.82
TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets. Proc Natl Acad Sci U S A (2015) 0.82
Identification of a gene encoding a typical gamma-carboxyglutamic acid domain in the tunicate Halocynthia roretzi. J Thromb Haemost (2003) 0.81
Functions and development of red pulp macrophages. Microbiol Immunol (2015) 0.80
Mer receptor tyrosine kinase mediates both tethering and phagocytosis of apoptotic cells. Cell Death Dis (2015) 0.80
P4-ATPases as Phospholipid Flippases-Structure, Function, and Enigmas. Front Physiol (2016) 0.79
Anoctamins/TMEM16 Proteins: Chloride Channels Flirting with Lipids and Extracellular Vesicles. Annu Rev Physiol (2016) 0.78
The Dynamics of Apoptotic Cell Clearance. Dev Cell (2016) 0.78
A Comprehensive Review of Mutations in the MERTK Proto-Oncogene. Adv Exp Med Biol (2016) 0.78
Complement emerges as a masterful regulator of CNS homeostasis, neural synaptic plasticity and cognitive function. Exp Neurol (2014) 0.78
Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia. Neuron (2017) 0.76
Regulation and regulatory role of gamma-carboxyglutamic acid containing clotting factors. Crit Rev Eukaryot Gene Expr (1996) 0.76
Lipid Tales of Viral Replication and Transmission. Trends Cell Biol (2016) 0.75
Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure. Proc Natl Acad Sci U S A (2016) 0.75