Arginine mutations in antibody complementarity-determining regions display context-dependent affinity/specificity trade-offs.

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Published in J Biol Chem on August 04, 2017

Authors

Kathryn E Tiller1, Lijuan Li1, Sandeep Kumar2, Mark C Julian1, Shekhar Garde1, Peter M Tessier3

Author Affiliations

1: From the Center for Biotechnology and Interdisciplinary Studies, Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 and.
2: Pharmaceutical Research and Development, Biotherapeutics Pharmaceutical Sciences, Pfizer Inc., Chesterfield, Missouri 63017.
3: From the Center for Biotechnology and Interdisciplinary Studies, Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York 12180 and ptessier@umich.edu.

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