Published in Stem Cell Reports on July 24, 2017
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 28.01
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol (1992) 11.03
Purification and characterization of hypoxia-inducible factor 1. J Biol Chem (1995) 8.53
Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors. Nature (2000) 7.15
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell (2002) 5.66
Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (2001) 5.46
Molecular biology of the Ets family of transcription factors. Gene (2003) 4.41
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell (1999) 4.17
Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14
Notch1 is essential for postimplantation development in mice. Genes Dev (1994) 4.06
Dll4, a novel Notch ligand expressed in arterial endothelium. Genes Dev (2000) 3.86
Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity. Nature (2005) 3.67
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq. Blood (2011) 3.00
Arterial-venous specification during development. Circ Res (2009) 2.49
ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell (2008) 2.46
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res (2007) 2.43
Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12
Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis. Biochim Biophys Acta (2007) 1.79
Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate. Exp Cell Res (2006) 1.77
Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation. Circ Res (2012) 1.74
Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci U S A (2009) 1.68
Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm. Blood (2011) 1.61
Role of nox2-based NADPH oxidase in bone marrow and progenitor cell function involved in neovascularization induced by hindlimb ischemia. Circ Res (2008) 1.52
Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20
ETS factors regulate Vegf-dependent arterial specification. Dev Cell (2013) 1.16
Hypoxia promotes efficient differentiation of human embryonic stem cells to functional endothelium. Stem Cells (2010) 1.11
Endothelial cell metabolism in normal and diseased vasculature. Circ Res (2015) 1.09
Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages. Dev Biol (2014) 1.05
Transcriptional regulation of endothelial cell and vascular development. Circ Res (2013) 1.03
Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells. PLoS One (2013) 0.95
Hypoxic priming of mESCs accelerates vascular-lineage differentiation through HIF1-mediated inverse regulation of Oct4 and VEGF. EMBO Mol Med (2012) 0.94
Low oxygen tension enhances endothelial fate of human pluripotent stem cells. Arterioscler Thromb Vasc Biol (2014) 0.94
Fli1 acts downstream of Etv2 to govern cell survival and vascular homeostasis via positive autoregulation. Circ Res (2014) 0.86
The E-domain region of mechano-growth factor inhibits cellular apoptosis and preserves cardiac function during myocardial infarction. Mol Cell Biochem (2013) 0.84
The molecular regulation of arteriovenous specification and maintenance. Dev Dyn (2015) 0.83
Integrin α6β1 Expressed in ESCs Instructs the Differentiation to Endothelial Cells. Stem Cells (2015) 0.83
Enhancement of differentiation efficiency of hESCs into vascular lineage cells in hypoxia via a paracrine mechanism. Stem Cell Res (2011) 0.78
Histone Demethylases KDM4A and KDM4C Regulate Differentiation of Embryonic Stem Cells to Endothelial Cells. Stem Cell Reports (2015) 0.78