Notch signaling is essential for vascular morphogenesis in mice.

Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res (2004) 5.60

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev (2003) 4.89

The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc Natl Acad Sci U S A (2007) 4.52

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41

Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A (2007) 4.27

Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev (2004) 4.14

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06

Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med (2008) 3.64

Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol (2003) 3.51

Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med (2007) 3.05

Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00

Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood (2005) 2.91

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature (2014) 2.70

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A (2003) 2.69

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein. Proc Natl Acad Sci U S A (2004) 2.66

A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest (2007) 2.57

Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium. Proc Natl Acad Sci U S A (2001) 2.56

beta8 integrins are required for vascular morphogenesis in mouse embryos. Development (2002) 2.55

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55

Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53

Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28

The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev (2001) 2.15

NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. Circ Res (2009) 2.15

Transcriptional control of endothelial cell development. Dev Cell (2009) 2.12

Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07

Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling. Proc Natl Acad Sci U S A (2000) 2.05

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood (2007) 2.01

Epidermal Notch signalling: differentiation, cancer and adhesion. Curr Opin Cell Biol (2008) 1.99

Notch signaling regulates tumor angiogenesis by diverse mechanisms. Oncogene (2008) 1.95

Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. Development (2007) 1.94

Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91

Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice. Proc Natl Acad Sci U S A (2005) 1.90

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype. Blood (2008) 1.83

Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. Mol Cell Biol (2002) 1.81

A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev Biol (2007) 1.65

The Notch ligand Jagged1 is required for inner ear sensory development. Proc Natl Acad Sci U S A (2001) 1.64

Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62

Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol (2001) 1.61

Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol Cell Biol (2004) 1.61

Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J Clin Invest (2007) 1.60

Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner. Nat Med (2011) 1.55

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis. Br J Cancer (2008) 1.55

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest (2010) 1.54

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (2010) 1.53

Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation. Mol Cell Biol (2002) 1.52

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest (2011) 1.51

Notch1 deficiency results in decreased inflammation during wound healing and regulates vascular endothelial growth factor receptor-1 and inflammatory cytokine expression in macrophages. J Immunol (2010) 1.49

Regulation of the embryonic morphogen Nodal by Notch4 facilitates manifestation of the aggressive melanoma phenotype. Cancer Res (2010) 1.49

Notch and the skeleton. Mol Cell Biol (2009) 1.49

Physiological Notch signaling promotes gliogenesis in the developing peripheral and central nervous systems. Development (2007) 1.47

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood (2008) 1.47

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts. Mol Cell Biol (2005) 1.46

Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A (2003) 1.45

Artery and vein size is balanced by Notch and ephrin B2/EphB4 during angiogenesis. Development (2008) 1.43

Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42

Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes. Circ Res (2010) 1.42

Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development (2008) 1.40

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice. Proc Natl Acad Sci U S A (2009) 1.38

p38 MAP kinase negatively regulates endothelial cell survival, proliferation, and differentiation in FGF-2-stimulated angiogenesis. J Cell Biol (2002) 1.38

VEGF and Notch in tip and stalk cell selection. Cold Spring Harb Perspect Med (2013) 1.38

NOTCH1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Hum Mol Genet (2008) 1.37

Notch2 signaling induces apoptosis and inhibits human MDA-MB-231 xenograft growth. Am J Pathol (2007) 1.36

Involvement of notch signaling in wound healing. PLoS One (2007) 1.35

Nrarp is a novel intracellular component of the Notch signaling pathway. Genes Dev (2001) 1.35

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood (2006) 1.34

Endothelial cell plasticity: how to become and remain a lymphatic endothelial cell. Development (2010) 1.34

Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. Am J Pathol (2001) 1.34

Notch1 represses osteogenic pathways in aortic valve cells. J Mol Cell Cardiol (2009) 1.32

Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol Cell Biol (2001) 1.31

Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development (2008) 1.30

Molecular determinants of NOTCH4 transcription in vascular endothelium. Mol Cell Biol (2005) 1.27

A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol (2003) 1.27

Mutations in NOTCH1 cause Adams-Oliver syndrome. Am J Hum Genet (2014) 1.26

Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol (2010) 1.23

Signalling pathways that control vertebrate haematopoietic stem cell specification. Nat Rev Immunol (2013) 1.21

Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis (2010) 1.20

Regulation of endothelial cell differentiation and specification. Circ Res (2013) 1.20

Dll4-Notch signaling as a therapeutic target in tumor angiogenesis. Vasc Cell (2011) 1.20

A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet (2013) 1.19

Signal transduction in vasculogenesis and developmental angiogenesis. Int J Dev Biol (2011) 1.17

ETS factors regulate Vegf-dependent arterial specification. Dev Cell (2013) 1.16

Altered Notch ligand expression in human liver disease: further evidence for a role of the Notch signaling pathway in hepatic neovascularization and biliary ductular defects. Am J Pathol (2002) 1.16

Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16

Notch-1 signalling is activated in brain arteriovenous malformations in humans. Brain (2009) 1.15

Bmx tyrosine kinase has a redundant function downstream of angiopoietin and vascular endothelial growth factor receptors in arterial endothelium. Mol Cell Biol (2001) 1.15

Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns (2006) 1.15

The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14

Suppression of Notch signaling in the neonatal mouse ovary decreases primordial follicle formation. Endocrinology (2008) 1.14

Molecular control of arterial-venous blood vessel identity. J Anat (2003) 1.13

Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice. Am J Pathol (2009) 1.12

Specification of arterial, venous, and lymphatic endothelial cells during embryonic development. Histol Histopathol (2010) 1.12

ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci (2008) 1.12

Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. J Virol (2006) 1.11

The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg (2005) 1.11

Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells. Blood Cells Mol Dis (2013) 1.11

Linkage analysis of left ventricular outflow tract malformations (aortic valve stenosis, coarctation of the aorta, and hypoplastic left heart syndrome). Eur J Hum Genet (2009) 1.11

TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent. Gene (2009) 1.11

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia. Circ Res (2010) 1.10

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