Combinations of isoform-targeted histone deacetylase inhibitors and bryostatin analogues display remarkable potency to activate latent HIV without global T-cell activation.

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Published in Sci Rep on August 07, 2017

Authors

Brice J Albert1, Austin Niu2, Rashmi Ramani2, Garland R Marshall3, Paul A Wender4, Robert M Williams5,6, Lee Ratner2, Alexander B Barnes7, George B Kyei8

Author Affiliations

1: Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri, 63130, USA.
2: Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, 63110, USA.
3: Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, 63110, USA.
4: Departments of Chemistry and Chemical and Systems Biology, Stanford University, Stanford, California, 94305, USA.
5: Department of Chemistry, Colorado State University, Fort Collins, Colorado, 80523, USA.
6: University of Colorado Cancer Centre, Aurora, Colorado, 80045, USA.
7: Department of Chemistry, Washington University in St. Louis , St. Louis, Missouri 63130, United States.
8: Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, Missouri, 63110, USA. g.kyei@wustl.edu.

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