PubRank

R Grosschedl

Author PubWeight™ 198.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Identification of regulatory sequences in the prelude sequences of an H2A histone gene by the study of specific deletion mutants in vivo. Proc Natl Acad Sci U S A 1980 16.88
2 Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 1996 15.88
3 Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell 1985 8.16
4 Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo. Proc Natl Acad Sci U S A 1980 7.31
5 Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice. Cell 1988 6.48
6 Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev 1994 6.07
7 LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]. Genes Dev 1991 5.95
8 PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev 2001 5.79
9 The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures. Cell 1992 5.24
10 Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 1995 4.34
11 Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 1995 4.14
12 Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin. Mol Cell Biol 1998 3.79
13 LEF-1, a nuclear factor coordinating signaling inputs from wingless and decapentaplegic. Cell 1997 3.63
14 Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature 1995 3.58
15 Regulation of LEF-1/TCF transcription factors by Wnt and other signals. Curr Opin Cell Biol 1999 3.52
16 Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways. Proc Natl Acad Sci U S A 1998 3.35
17 Generation of authentic 3' termini of an H2A mRNA in vivo is dependent on a short inverted DNA repeat and on spacer sequences. Cell 1982 3.35
18 A tRNA gene of Xenopus laevis contains at least two sites promoting transcription. Nucleic Acids Res 1979 3.30
19 Introduction of a mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 1984 3.24
20 Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity 2000 3.19
21 Two regulatory elements for immunoglobulin kappa light chain gene expression. Proc Natl Acad Sci U S A 1984 2.98
22 Delimitation of a promoter for RNA polymerase III by means of a functional test. Proc Natl Acad Sci U S A 1979 2.97
23 Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev 1999 2.94
24 Delimitation of far upstream sequences required for maximal in vitro transcription of an H2A histone gene. Proc Natl Acad Sci U S A 1982 2.90
25 ALY, a context-dependent coactivator of LEF-1 and AML-1, is required for TCRalpha enhancer function. Genes Dev 1997 2.78
26 Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity 1998 2.57
27 DNA-binding properties of the HMG domain of the lymphoid-specific transcriptional regulator LEF-1. Genes Dev 1991 2.56
28 Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev 1996 2.42
29 Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 1999 2.35
30 ClaI. a new restriction endonuclease from Caryophanon latum L. Nucleic Acids Res 1981 2.21
31 Functional analysis of the replicator structure of lambdoid bacteriophage DNAs. Cold Spring Harb Symp Quant Biol 1979 2.18
32 DNA sequences and structural homologies of the replication origins of lambdoid bacteriophages. Nature 1979 2.13
33 Extension of chromatin accessibility by nuclear matrix attachment regions. Nature 1997 2.06
34 Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development 2000 2.01
35 LEF-1 contains an activation domain that stimulates transcription only in a specific context of factor-binding sites. EMBO J 1993 2.01
36 EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes. Immunity 1997 1.95
37 Dependence of enhancer-mediated transcription of the immunoglobulin mu gene on nuclear matrix attachment regions. Science 1994 1.91
38 Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression. Genes Dev 1993 1.84
39 An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc Natl Acad Sci U S A 1992 1.80
40 LEF-1/TCF proteins mediate wnt-inducible transcription from the Xenopus nodal-related 3 promoter. Dev Biol 1997 1.78
41 Nucleotide sequence of the cro-cII-oop region of bacteriophage 434 DNA. Nucleic Acids Res 1979 1.78
42 A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation. EMBO J 1991 1.65
43 The immunoglobulin mu enhancer core establishes local factor access in nuclear chromatin independent of transcriptional stimulation. Genes Dev 1993 1.57
44 EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains. EMBO J 1995 1.57
45 Ebf1 controls early cell differentiation in the embryonic striatum. Development 1999 1.53
46 Point mutation in the TATA box curtails expression of sea urchin H2A histone gene in vivo. Nature 1981 1.51
47 Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression. Proc Natl Acad Sci U S A 2001 1.35
48 Complex pattern of immunoglobulin mu gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev 1991 1.30
49 Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol Cell Biol 2001 1.28
50 Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors. Proc Natl Acad Sci U S A 1994 1.27
51 Transcriptional control of lymphoid development: lessons from gene targeting. Immunol Today 1996 1.27
52 Transcriptional regulation of B-cell differentiation. Curr Opin Immunol 1998 1.26
53 Purification of early-B-cell factor and characterization of its DNA-binding specificity. Mol Cell Biol 1993 1.24
54 TNF signaling via the ligand-receptor pair ectodysplasin and edar controls the function of epithelial signaling centers and is regulated by Wnt and activin during tooth organogenesis. Dev Biol 2001 1.24
55 Nuclear matrix attachment regions antagonize methylation-dependent repression of long-range enhancer-promoter interactions. Genes Dev 1999 1.24
56 Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Development 1999 1.24
57 Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences. Mol Cell Biol 1991 1.17
58 Depletion of the predominant B-cell population in immunoglobulin mu heavy-chain transgenic mice. Nature 1987 1.11
59 Regulation of gene expression at early stages of B-cell differentiation. Curr Opin Immunol 1994 1.00
60 Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1. Proc Natl Acad Sci U S A 1997 0.99
61 A functional component of the sea urchin H2A gene modulator contains an extended sequence homology to a viral enhancer. Nucleic Acids Res 1983 0.99
62 Gene for lymphoid enhancer-binding factor 1 (LEF1) mapped to human chromosome 4 (q23-q25) and mouse chromosome 3 near Egf. Genomics 1991 0.98
63 The membrane IgM-associated proteins MB-1 and Ig-beta are sufficient to promote surface expression of a partially functional B-cell antigen receptor in a nonlymphoid cell line. Proc Natl Acad Sci U S A 1992 0.97
64 Wnt signaling in lymphopoiesis. Curr Top Microbiol Immunol 2005 0.92
65 Transcriptional regulation of early B-lymphocyte differentiation. Immunol Rev 2000 0.92
66 Nuclear matrix attachment regions confer long-range function upon the immunoglobulin mu enhancer. Cold Spring Harb Symp Quant Biol 1998 0.90
67 Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11. Mamm Genome 1994 0.89
68 A mouse mandibular culture model permits the study of neural crest cell migration and tooth development. Int J Dev Biol 1998 0.85
69 Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors. Cold Spring Harb Symp Quant Biol 1999 0.79
70 Identification of the regions involved in DNA binding by the mouse PEBP2alpha protein. FEBS Lett 2000 0.78
71 Role of enhancer sequences in regulating accessibility of DNA in nuclear chromatin. Cold Spring Harb Symp Quant Biol 1993 0.76
72 Studies of immunodifferentiation using transgenic mice. Cold Spring Harb Symp Quant Biol 1985 0.75
73 Role of the OCTA site in regulation of IgH chain gene transcription during B cell activation. Int Immunol 1995 0.75