Published in Proc Natl Acad Sci U S A on March 01, 1987
A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1. EMBO J (1988) 1.79
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Negative regulation in correct tissue-specific expression of mouse mammary tumor virus in transgenic mice. Mol Cell Biol (1990) 1.23
Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. Proc Natl Acad Sci U S A (1989) 1.13
Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1. Proc Natl Acad Sci U S A (1988) 1.11
Transcriptional regulation of genes for ornithine cycle enzymes. Biochem J (1995) 0.98
Tse-2: a trans-dominant extinguisher of albumin gene expression in hepatoma hybrid cells. Mol Cell Biol (1989) 0.93
Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids. Nucleic Acids Res (1997) 0.90
Hormonal regulation of TSE1-repressed genes: evidence for multiple genetic controls in extinction. Mol Cell Biol (1989) 0.89
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. Mol Cell Biol (1994) 0.87
Extinction of JC virus tumor-antigen expression in glial cell--fibroblast hybrids. Proc Natl Acad Sci U S A (1988) 0.85
A mechanism generating heterogeneity in thyroid epithelial cells: suppression of the thyrotropin/cAMP-dependent mitogenic pathway after cell division induced by cAMP-independent factors. J Cell Biol (1992) 0.83
Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain. Mol Cell Biol (1990) 0.83
A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene. Nucleic Acids Res (1989) 0.80
Extinction and activation of the thyroglobulin promoter in hybrids of differentiated and transformed thyroid cells. Mol Cell Biol (1990) 0.79
Regulation of chimeric phosphoenolpyruvate carboxykinase genes by the trans-dominant locus TSE1. Mol Cell Biol (1990) 0.78
Differential activity of a tissue-specific extinguisher locus in hepatic and nonhepatic cells. Mol Cell Biol (1989) 0.76
Transactivation of pancreas-specific gene sequences in somatic cell hybrids. Mol Cell Biol (1991) 0.76
Extinction of retinol-binding protein gene expression in somatic cell-hybrids: identification of the target sequences. Nucleic Acids Res (1990) 0.76
The tissue-specific pathways regulating cell proliferation are inherited independently in somatic hybrid between thyroid and liver cells. J Cell Biol (1990) 0.76
Genomic sequencing. Proc Natl Acad Sci U S A (1984) 92.36
A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell (1983) 20.32
A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell (1983) 18.86
Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53
Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35
Cell-specific expression controlled by the 5'-flanking region of insulin and chymotrypsin genes. Nature (1984) 8.65
The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61
The rat serum albumin gene: analysis of cloned sequences. Proc Natl Acad Sci U S A (1979) 5.17
A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell (1984) 3.60
HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO. Natl Cancer Inst Monogr (1964) 3.53
Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A (1975) 3.05
Transcriptional "silencer" element in rat repetitive sequences associated with the rat insulin 1 gene locus. Proc Natl Acad Sci U S A (1986) 2.95
Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Mol Cell Biol (1983) 2.85
Regulation of rat insulin 1 gene expression: evidence for negative regulation in nonpancreatic cells. Proc Natl Acad Sci U S A (1986) 2.57
Regulation of pigment synthesis in mammalian cells, as studied by somatic hybridization. Proc Natl Acad Sci U S A (1966) 2.36
Cell-specific enhancers in the rat exocrine pancreas. Proc Natl Acad Sci U S A (1986) 2.02
Expression of differentiated functions in hepatoma cell hybrids: reappearance of tyrosine aminotransferase inducibility after the loss of chromosomes. Proc Natl Acad Sci U S A (1971) 2.01
Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Proc Natl Acad Sci U S A (1983) 1.99
Expression of differentiated functions in hepatoma cell hybrids. I. Tyrosine aminotransferase in hepatoma-fibroblast hybrids. Proc Natl Acad Sci U S A (1971) 1.80
Isolation of cDNA clones coding for rat tyrosine aminotransferase. Proc Natl Acad Sci U S A (1982) 1.65
Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids. J Cell Biol (1981) 1.55
Expression of tyrosine aminotransferase activity in somatic-cell heterokaryons: evidence for negative control of enzyme expression. Proc Natl Acad Sci U S A (1971) 1.42
Cloning and sequencing of a full length cDNA coding for human retinol-binding protein. Nucleic Acids Res (1983) 1.36
Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids. Proc Natl Acad Sci U S A (1986) 1.36
Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones. Proc Natl Acad Sci U S A (1984) 1.30
Expression of the albumin gene in rat hepatoma cells and their dedifferentiated variants. Cell (1981) 1.30
Cloning and sequencing of cDNA encoding the complete mouse liver alcohol dehydrogenase. Proc Natl Acad Sci U S A (1985) 1.13
Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement. Proc Natl Acad Sci U S A (1982) 1.09
Expression of differentiated functions in hepatoma cell hybrids: high frequency of induction of mouse albumin production in rat hepatoma-mouse lymphoblast hybrids. Proc Natl Acad Sci U S A (1974) 1.08
Expression of differentiated functions in hepatoma cell hybrids: IX extinction and reexpression of liver-specific enzymes in rat hepatoma-Chinese hamster fibroblast hybrids. Somatic Cell Genet (1975) 1.04
Molecular cloning of cDNA for rat and human carbamyl phosphate synthetase I. J Biol Chem (1984) 1.02
Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells. Mol Cell Biol (1985) 1.00
Extinction of muscle-specific properties in somatic cell heterokaryons. Dev Biol (1984) 0.92
A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell (1984) 3.60
Identification of a cAMP regulatory region in the gene for rat cytosolic phosphoenolpyruvate carboxykinase (GTP). Use of chimeric genes transfected into hepatoma cells. J Biol Chem (1984) 2.27
Participation of the human beta-globin locus control region in initiation of DNA replication. Science (1995) 2.18
Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells. Proc Natl Acad Sci U S A (1977) 1.97
Multigene family for sarcomeric myosin heavy chain in mouse and human DNA: localization on a single chromosome. Science (1983) 1.74
Characterization of cDNAs encoding human leukosialin and localization of the leukosialin gene to chromosome 16. Proc Natl Acad Sci U S A (1989) 1.68
A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell (1990) 1.67
Physical mapping of the von Recklinghausen neurofibromatosis region on chromosome 17. Am J Hum Genet (1989) 1.54
Stable association of the human transgenome and host murine chromosomes demonstrated with trispecific microcell hybrids. Proc Natl Acad Sci U S A (1977) 1.45
Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Sci U S A (1988) 1.43
Identification and characterization of Drosophila genes for synaptic vesicle proteins. J Neurosci (1993) 1.40
Assignment of the human and mouse prion protein genes to homologous chromosomes. Proc Natl Acad Sci U S A (1986) 1.33
Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell (1990) 1.30
Isolation of microcell hybrid clones containing retroviral vector insertions into specific human chromosomes. Mol Cell Biol (1987) 1.30
Subtractive hybridization cloning of a tissue-specific extinguisher: TSE1 encodes a regulatory subunit of protein kinase A. Cell (1991) 1.28
Position-independent transgene expression mediated by boundary elements from the apolipoprotein B chromatin domain. Mol Cell Biol (1995) 1.26
Large scrotal hernia: a complicated case of mesh migration, ascites, and bowel strangulation. Hernia (2004) 1.23
A general high-efficiency procedure for production of microcell hybrids. Proc Natl Acad Sci U S A (1981) 1.22
Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. J Antimicrob Chemother (2000) 1.20
Clustering of cytokine genes on mouse chromosome 11. J Exp Med (1990) 1.15
Assignment of the gene governing cellular ouabain resistance to Mus musculus chromosome 3 using human/mouse microcell hybrids. Biochem Genet (1979) 1.12
Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1. Proc Natl Acad Sci U S A (1988) 1.11
Complementation mapping in microcell hybrids: localization of Fpgs and Ak-1 on Mus musculus chromosome 2. Somatic Cell Genet (1983) 1.10
Human matrix attachment regions insulate transgene expression from chromosomal position effects in Drosophila melanogaster. Mol Cell Biol (1998) 1.10
Efficient modification of human chromosomal alleles using recombination-proficient chicken/human microcell hybrids. Nat Genet (1996) 1.07
Construction of microcell hybrid clones containing specific mouse chromosomes: application to autosomes 8 and 17. Mol Cell Biol (1982) 1.06
Two NF1 translocations map within a 600-kilobase segment of 17q11.2. Science (1989) 1.05
Cell cycle studies of mononucleate and cytochalasin-B--nduced binucleate fibroblasts. Proc Natl Acad Sci U S A (1975) 1.05
Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells. Mol Cell Biol (1985) 1.00
The 5' boundary of the human apolipoprotein B chromatin domain in intestinal cells. Biochemistry (2001) 0.99
Genetic analysis of mammalian cell differentiation. Annu Rev Cell Biol (1990) 0.97
The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1. Proc Natl Acad Sci U S A (1999) 0.95
Physical mapping of human chromosome 17 using fragment-containing microcell hybrids. Genomics (1989) 0.95
Transport of dicarboxylic acids in Bacillus subtilis. Inducible uptake of L-malate. J Biol Chem (1972) 0.95
Monoclonal antibodies specific to porin of Haemophilus influenzae type b: localization of their cognate epitopes and tests of their biological activities. Mol Microbiol (1992) 0.94
Cellular homologs of the avian erythroblastosis virus erb-A and erb-B genes are syntenic in mouse but asyntenic in man. Proc Natl Acad Sci U S A (1984) 0.94
Extinction of alpha 1-antitrypsin gene expression in somatic cell hybrids: evidence for multiple controls. Genes Dev (1992) 0.94
Assignment of the gene encoding cytosolic phosphoenolpyruvate carboxykinase (GTP) to Mus musculus chromosome 2. Somat Cell Mol Genet (1985) 0.94
Isolation of thymidine kinase-deficient rat hepatoma cells by selection with bromodeoxyuridine, Hoechst 33258, and visible light. Biochem Genet (1984) 0.93
Tse-2: a trans-dominant extinguisher of albumin gene expression in hepatoma hybrid cells. Mol Cell Biol (1989) 0.93
Evidence for inducible, L-malate binding proteins in the membrane of Bacillus subtilis. Identification of presumptive components of the C4-dicarboxylate transport systems. J Biol Chem (1974) 0.92
Value of helical computed tomography, angiography, and endoscopic ultrasound in determining resectability of periampullary carcinoma. Am J Surg (1997) 0.90
Multiple elements regulate phosphoenolpyruvate carboxykinase gene expression in hepatoma hybrid cells. Somat Cell Mol Genet (1992) 0.89
Identification and characterization of nuclear matrix-attachment regions in the human serpin gene cluster at 14q32.1. Nucleic Acids Res (1999) 0.89
Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogenet Cell Genet (1978) 0.89
Hormonal regulation of TSE1-repressed genes: evidence for multiple genetic controls in extinction. Mol Cell Biol (1989) 0.89
Long-range chromatin reorganization of the human serpin gene cluster at 14q32.1 accompanies gene activation and extinction in microcell hybrids. Genomics (1999) 0.89
Regional assignment of ADA and ITPA to mouse chromosome 2 (C1----ter). A demonstration of the conserved linkage of enzyme and proto-oncogene loci. J Hered (1984) 0.87
Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. Mol Cell Biol (1994) 0.87
Somatic cell genetic analysis of transgenome integration. Somatic Cell Genet (1979) 0.87
Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol (1987) 0.87
Assignment of the Ly-6--Ril-1--Sis--H-30--Pol-5/Xmmv-72--Ins-3--Krt-1--Int-1 --Gdc-1 region to mouse chromosome 15. Immunogenetics (1987) 0.87
Microcell fusion. Methods Enzymol (1995) 0.86
Differential regulation of gene activity and chromatin structure within the human serpin gene cluster at 14q32.1 in macrophage microcell hybrids. Nucleic Acids Res (2000) 0.86
Recombinant porin of Haemophilus influenzae type b. J Infect Dis (1992) 0.85
Extinction of phosphoenolpyruvate carboxykinase gene expression is associated with loss of a specific chromatin-binding protein from a far upstream domain. Mol Cell Biol (1990) 0.83
The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes. Genomics (1995) 0.82
Identification of the human beta A2 crystallin gene (CRYBA2): localization of the gene on human chromosome 2 and of the homologous gene on mouse chromosome 1. Genomics (1995) 0.82
Molecular linkage of the human alpha 1-antitrypsin and corticosteroid-binding globulin genes on chromosome 14q32.1. Mamm Genome (1997) 0.81
Direct selection of hepatoma cell variants deficient in alpha 1-antitrypsin gene expression. Somat Cell Mol Genet (1992) 0.81
Tissue-specific extinguisher loci in the human genome: a screening study based on random marking and transfer of human chromosomes. Somat Cell Mol Genet (1994) 0.80
Extinction of albumin gene expression in a panel of human chromosome 2 microcell hybrids. Genomics (1996) 0.80
The angiotensinogen gene is located on mouse chromosome 8. FEBS Lett (1989) 0.80
Construction of a panel of canine-rodent hybrid cell lines for use in partitioning of the canine genome. Genomics (1997) 0.79
Somatic cell genetic analysis of gene transfer in mammalian cells. Brookhaven Symp Biol (1979) 0.79
Regulation of chimeric phosphoenolpyruvate carboxykinase genes by the trans-dominant locus TSE1. Mol Cell Biol (1990) 0.78
Genetic and probability aspects of cell transformation by chemical carcinogens. Prog Nucleic Acid Res Mol Biol (1983) 0.78
Stable expression and cell-specific chromatin structure of human alpha1-antitrypsin cosmid transgenes in rat hepatoma cells. Nucleic Acids Res (2000) 0.78
Microcell-mediated transfer of carcinogen-induced ouabain resistance from C3H/10T1/2 Cl 8 mouse fibroblasts to human cells. Mutat Res (1983) 0.77
Partial activation of gene activity and chromatin remodeling of the human 14q32.1 serpin gene cluster by HNF-1 alpha and HNF-4 in fibroblast microcell hybrids. Somat Cell Mol Genet (1999) 0.77
Isolation and characterization of human hepatoma cells with targeted insertions of a gpt selectable marker in the alpha 1-antitrypsin locus. Somat Cell Mol Genet (1996) 0.77
Assignment of genes encoding dihydrofolate reductase and hexosaminidase B to Mus musculus chromosome 13. Somat Cell Mol Genet (1986) 0.77
Differential activity of a tissue-specific extinguisher locus in hepatic and nonhepatic cells. Mol Cell Biol (1989) 0.76
Isolation and characterization of HPRT-deficient human hepatoma cells. Somat Cell Mol Genet (1996) 0.76
Tissue-specific extinguisher loci in the murine genome: a screening study based on a rat/mouse microcell hybrid panel. Somat Cell Mol Genet (1994) 0.76
Giant hepatic adenoma with atypical features in a patient on oxcarbazepine therapy. J Pediatr Surg (2008) 0.76
Cloning mammary cell cDNAs from 17q12-q23 using interspecific somatic cell hybrids and subtractive hybridization. Genomics (1995) 0.76
Parasexual approaches to the study of human genetic disease. Ann N Y Acad Sci (1986) 0.75
The relaxin gene is located on chromosome 19 in the mouse. FEBS Lett (1991) 0.75
An isozyme-specific selective system for the recovery of mammalian cells deficient in hepatic alcohol dehydrogenase activity. Exp Cell Res (1984) 0.75
Cloning and functional promoter mapping of the rat serotonin-2 receptor gene. Mol Cell Neurosci (1994) 0.75
Generation of region- and species-specific expressed gene probes from somatic cell hybrids. Nat Genet (1992) 0.75
Genetic activity of a trans-regulatory locus in hepatoma hybrid cells. Mol Biol Med (1989) 0.75
Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker. DNA (1987) 0.75
Tissue-specific expression of hepatic functions. Genetic aspects. Ann N Y Acad Sci (1986) 0.75
Assignment of matrix metalloproteinase 9 (Mmp9) to mouse chromosome 2 bands H1-H2. Cytogenet Cell Genet (1996) 0.75
Cytokeratin gene expression in hepatoma hybrid cells: evidence for regulation in cis. Somat Cell Mol Genet (1989) 0.75