Lef1-dependent hypothalamic neurogenesis inhibits anxiety.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 28837622)

Published in PLoS Biol on August 24, 2017

Authors

Yuanyuan Xie1, Dan Kaufmann2, Matthew J Moulton3, Samin Panahi1, John A Gaynes1, Harrison N Watters1, Dingxi Zhou1,4, Hai-Hui Xue5, Camille M Fung6, Edward M Levine7, Anthea Letsou3, K C Brennan2, Richard I Dorsky1

Author Affiliations

1: Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, United States of America.
2: Department of Neurology, University of Utah, Salt Lake City, Utah, United States of America.
3: Department of Human Genetics, University of Utah, Salt Lake City, Utah, United States of America.
4: School of Life Sciences, Peking University, Beijing, China.
5: Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.
6: Division of Neonatology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America.
7: Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, United States of America.

Articles cited by this

Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc (2008) 62.52

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat Neurosci (2009) 21.94

Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31

The Genotype-Tissue Expression (GTEx) project. Nat Genet (2013) 10.77

High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat Protoc (2008) 10.25

Human genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans. Science (2015) 9.92

Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics (2012) 8.61

Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell (1997) 8.23

A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes. Histochemistry (1993) 7.78

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice. Genes Dev (1994) 6.07

GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res (2004) 5.45

PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res (2009) 5.03

tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A (2005) 4.15

Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. Nature (2012) 3.81

A Drosophila full-length cDNA resource. Genome Biol (2002) 3.67

Human genomics. The human transcriptome across tissues and individuals. Science (2015) 3.53

Fate mapping Nkx2.1-lineage cells in the mouse telencephalon. J Comp Neurol (2008) 3.39

Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature (1998) 3.38

Cloning of the zebrafish krox-20 gene (krx-20) and its expression during hindbrain development. Nucleic Acids Res (1993) 3.31

Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci (1998) 3.17

pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila. Nature (1997) 3.15

Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters. Genome Res (2003) 2.57

A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Dev Biol (2002) 2.46

An anatomic gene expression atlas of the adult mouse brain. Nat Neurosci (2009) 2.30

A genomic atlas of mouse hypothalamic development. Nat Neurosci (2010) 2.25

The TCF-1 and LEF-1 transcription factors have cooperative and opposing roles in T cell development and malignancy. Immunity (2012) 2.15

Taming anxiety in laboratory mice. Nat Methods (2010) 2.15

The Sp1-related transcription factors sp5 and sp5-like act downstream of Wnt/beta-catenin signaling in mesoderm and neuroectoderm patterning. Curr Biol (2005) 2.09

Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development (2000) 2.01

A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse. BMC Dev Biol (2010) 1.92

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents. Trends Neurosci (2012) 1.90

A zebrafish histone variant H2A.F/Z and a transgenic H2A.F/Z:GFP fusion protein for in vivo studies of embryonic development. Dev Genes Evol (2001) 1.74

Order and coherence in the fate map of the zebrafish nervous system. Development (1995) 1.58

Simplex PCR assay for sex determination in mice. Biotechniques (2005) 1.46

Mice with MCH ablation resist diet-induced obesity through strain-specific mechanisms. Am J Physiol Regul Integr Comp Physiol (2005) 1.45

Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development (2006) 1.38

Zebrafish in endocrine systems: recent advances and implications for human disease. Annu Rev Physiol (2011) 1.36

Comparative anatomy of the histaminergic and other aminergic systems in zebrafish (Danio rerio). J Comp Neurol (2001) 1.35

Evolution of transcription factor binding in metazoans - mechanisms and functional implications. Nat Rev Genet (2014) 1.33

Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience (2008) 1.31

Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification. J Vis Exp (2012) 1.31

A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron (2014) 1.23

Late-onset leanness in mice with targeted ablation of melanin concentrating hormone neurons. J Neurosci (2006) 1.22

β-catenin mediates stress resilience through Dicer1/microRNA regulation. Nature (2014) 1.21

The neuroendocrine system of invertebrates: a developmental and evolutionary perspective. J Endocrinol (2006) 1.19

Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development (2011) 1.13

The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol (2012) 1.09

Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell (2012) 1.09

Sex differences and stress across the lifespan. Nat Neurosci (2015) 1.07

Altered anxiety and weight gain in corticotropin-releasing hormone-binding protein-deficient mice. Proc Natl Acad Sci U S A (1999) 1.04

Enhanced running wheel activity of both Mch1r- and Pmch-deficient mice. Regul Pept (2005) 1.03

Ontogenetic development of the diencephalic MCH neurons: a hypothalamic 'MCH area' hypothesis. Eur J Neurosci (2001) 1.01

Maternal and embryonic expression of zebrafish lef1. Mech Dev (1999) 1.00

Synthesis of cRNA probes from PCR-generated DNA. Biotechniques (1992) 0.99

Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists. J Mol Neurosci (2010) 0.98

Ablation of neurons expressing melanin-concentrating hormone (MCH) in adult mice improves glucose tolerance independent of MCH signaling. J Neurosci (2013) 0.97

Genetic basis of anxiety-like behaviour: a critical review. Brain Res Bull (2002) 0.96

Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system. J Comp Neurol (2009) 0.94

Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol Metab (2009) 0.92

Cell and molecular cell biology of melanin-concentrating hormone. Int Rev Cytol (2002) 0.92

Identification of Wnt-responsive cells in the zebrafish hypothalamus. Zebrafish (2009) 0.92

Structured evaluation of rodent behavioral tests used in drug discovery research. Front Behav Neurosci (2014) 0.89

The dorsal-open group gene raw is required for restricted DJNK signaling during closure. Development (1999) 0.89

Vgll2a is required for neural crest cell survival during zebrafish craniofacial development. Dev Biol (2011) 0.88

SALL4 is directly activated by TCF/LEF in the canonical Wnt signaling pathway. Biochem Biophys Res Commun (2006) 0.86

Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks. Nat Commun (2016) 0.84

Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol (2016) 0.83

Stress, neuropeptides, and feeding behavior: a comparative perspective. Integr Comp Biol (2002) 0.82

The remarkable conservation of corticotropin-releasing hormone (CRH)-binding protein in the honeybee (Apis mellifera) dates the CRH system to a common ancestor of insects and vertebrates. Endocrinology (2005) 0.82

The vertebrate diencephalic MCH system: a versatile neuronal population in an evolving brain. Front Neuroendocrinol (2012) 0.81

Anatomy, function and regulation of neuropeptide EI (NEI). Peptides (2008) 0.80

Specification of select hypothalamic circuits and innate behaviors by the embryonic patterning gene dbx1. Neuron (2015) 0.80

Lineage Tracing Using Cux2-Cre and Cux2-CreERT2 Mice. Neuron (2015) 0.79

Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development. Int J Dev Neurosci (2011) 0.79

Hypothalamic radial glia function as self-renewing neural progenitors in the absence of Wnt/β-catenin signaling. Development (2015) 0.79

How Transcription Networks Evolve and Produce Biological Novelty. Cold Spring Harb Symp Quant Biol (2015) 0.79

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell (2017) 0.78

Melanin-concentrating hormone: a general vertebrate neuropeptide. Int Rev Cytol (1991) 0.77

Motor Behavior Mediated by Continuously Generated Dopaminergic Neurons in the Zebrafish Hypothalamus Recovers after Cell Ablation. Curr Biol (2016) 0.77

Development of the hypothalamus: conservation, modification and innovation. Development (2017) 0.76

GeneNetwork: A Toolbox for Systems Genetics. Methods Mol Biol (2017) 0.75