Published in Lancet on June 27, 1987
An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest (1990) 10.35
Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ (1992) 4.53
Erythroblastic islands: niches for erythropoiesis. Blood (2008) 2.93
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. Circ Cardiovasc Genet (2009) 1.51
Molecular genetics of common diseases. Br Med J (Clin Res Ed) (1987) 1.49
Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease. Acta Physiol (Oxf) (2009) 1.18
Fibrinogen in relation to personal history of prevalent hypertension, diabetes, stroke, intermittent claudication, coronary heart disease, and family history: the Scottish Heart Health Study. Br Heart J (1993) 1.09
Genetic Modulation of Plasma Fibrinogen Concentrations: Possible Importance of Interleukin-6. J Thromb Thrombolysis (1996) 0.82
The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers. J Med Genet (1995) 0.80
Genetic and environmental sources of fibrinogen variability in Israeli families: the Kibbutzim Family Study. Am J Hum Genet (1995) 0.80
Fibrinogen and cardiovascular disease. J Clin Pathol (1997) 0.80
Genetic variation at fibrinogen loci and plasma fibrinogen levels. J Med Genet (1992) 0.79
A genetic instrument for Mendelian randomization of fibrinogen. Eur J Epidemiol (2012) 0.78
The association between thrombophilic gene mutations and recurrent pregnancy loss. J Assist Reprod Genet (2013) 0.78
Fibrinogen and mechanisms of thrombosis. A difficult link. Eur J Epidemiol (1992) 0.77
Interactions among Candidate Genes Selected by Meta-Analyses Resulting in Higher Risk of Ischemic Stroke in a Chinese Population. PLoS One (2015) 0.76
Risk factors for thromboembolism: pathophysiology and detection. CMAJ (2000) 0.75
Prevalence of urinary incontinence. Br Med J (1980) 7.11
Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet (1986) 6.51
Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis. JAMA (2005) 5.60
Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2001) 5.17
The trouble with ethics committees. J R Coll Physicians Lond (1994) 5.07
Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis (2000) 4.88
Seasonal variations of plasma fibrinogen and factor VII activity in the elderly: winter infections and death from cardiovascular disease. Lancet (1994) 4.85
Relation of fetal and infant growth to plasma fibrinogen and factor VII concentrations in adult life. BMJ (1992) 4.53
Accuracy of diagnosis on death certificates compared with that in hospital records. Br J Prev Soc Med (1967) 4.17
The Emerging Risk Factors Collaboration: analysis of individual data on lipid, inflammatory and other markers in over 1.1 million participants in 104 prospective studies of cardiovascular diseases. Eur J Epidemiol (2007) 3.81
Strategies for prevention of osteoporosis and hip fracture. BMJ (1991) 3.78
Errors in the polymerase chain reaction. Nucleic Acids Res (1988) 3.52
Haemostatic function and cardiovascular death: early results of a prospective study. Lancet (1980) 3.25
Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet (1993) 3.03
Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. Br Med J (1979) 2.98
Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor. Nat Genet (1994) 2.91
The role of HLA class II genes in insulin-dependent diabetes mellitus: molecular analysis of 180 Caucasian, multiplex families. Am J Hum Genet (1996) 2.90
Population-based distributions of haemostatic variables. Br Med Bull (1977) 2.83
Cholesteryl ester transfer protein TaqIB variant, high-density lipoprotein cholesterol levels, cardiovascular risk, and efficacy of pravastatin treatment: individual patient meta-analysis of 13,677 subjects. Circulation (2005) 2.77
Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels. Thromb Haemost (2000) 2.74
Human CRP gene polymorphism influences CRP levels: implications for the prediction and pathogenesis of coronary heart disease. Arterioscler Thromb Vasc Biol (2003) 2.63
Multicentre trial of physiotherapy in the management of sciatic symptoms. Lancet (1981) 2.59
Apo B versus cholesterol in estimating cardiovascular risk and in guiding therapy: report of the thirty-person/ten-country panel. J Intern Med (2006) 2.55
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol (1997) 2.53
Fetal and infant growth and cardiovascular risk factors in women. BMJ (1995) 2.52
How common are polycystic ovaries in normal women and what is their significance for the fertility of the population? Clin Endocrinol (Oxf) (1992) 2.49
Extent of underdiagnosis of familial hypercholesterolaemia in routine practice: prospective registry study. BMJ (2000) 2.40
Faecal bile-acids and clostridia in patients with cancer of the large bowel. Lancet (1975) 2.40
The gastrointestinal toxicity of aspirin: an overview of randomised controlled trials. Br J Clin Pharmacol (1993) 2.39
Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose. Anal Biochem (1994) 2.38
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. J Biol Chem (1996) 2.36
Interleukin-6 (IL-6) and the prognosis of abdominal aortic aneurysms. Circulation (2001) 2.29
Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain. Nature (1989) 2.23
Revised U.K. guidelines for the management of cutaneous melanoma 2010. Br J Dermatol (2010) 2.22
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev (1991) 2.20
Hippocampal volume in first-episode psychoses and chronic schizophrenia: a high-resolution magnetic resonance imaging study. Arch Gen Psychiatry (1999) 2.14
Repeatability and validity of a modified activities of daily living (ADL) index in studies of chronic disability. Int Rehabil Med (1979) 2.14
Long-term effects of hemostatic variables on fatal coronary heart disease: 30-year results from the first prospective Northwick Park Heart Study (NPHS-I). J Thromb Haemost (2006) 2.11
Effects of changes in smoking and other characteristics on clotting factors and the risk of ischaemic heart disease. Lancet (1987) 2.10
Update and analysis of the University College London low density lipoprotein receptor familial hypercholesterolemia database. Ann Hum Genet (2008) 2.05
Hormone replacement therapy in general practice: a survey of doctors in the MRC's general practice research framework. BMJ (1991) 2.02
Antithrombin III and arterial disease. Lancet (1991) 1.98
Interleukin-6 gene -174g>c and -572g>c promoter polymorphisms are strong predictors of plasma interleukin-6 levels after coronary artery bypass surgery. Arterioscler Thromb Vasc Biol (2001) 1.96
Linkage studies of X-linked recessive spastic paraplegia using DNA probes. Hum Genet (1986) 1.92
Increased incidence of neoplasia of the digestive tract in men with persistent activation of the coagulant pathway. J Thromb Haemost (2004) 1.91
Plasma concentrations of fibrinogen and factor VII in adult life and their relation to intra-uterine growth. Br J Haematol (1995) 1.91
Haemostatic variables associated with diabetes and its complications. Br Med J (1979) 1.90
Ischaemic heart disease mortality risks for smokers and non-smokers. J Epidemiol Community Health (1979) 1.85
Harvesting the genome's bounty: integrative genomics. Cold Spring Harb Symp Quant Biol (2003) 1.84
Remedial therapy after stroke: a randomised controlled trial. Br Med J (Clin Res Ed) (1981) 1.84
Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6. Eur Heart J (2000) 1.83
Screening for hypercholesterolaemia versus case finding for familial hypercholesterolaemia: a systematic review and cost-effectiveness analysis. Health Technol Assess (2000) 1.80
Human gene for physical performance. Nature (1998) 1.78
Is recruitment more difficult with a placebo arm in randomised controlled trials? A quasirandomised, interview based study. BMJ (1999) 1.76
Genetic causes of familial hypercholesterolaemia in patients in the UK: relation to plasma lipid levels and coronary heart disease risk. J Med Genet (2006) 1.76
Changes in haemostatic system after application of a tourniquet. Lancet (1977) 1.70
A distinct Hox code for the branchial region of the vertebrate head. Nature (1991) 1.70
Fibrinogen: a possible link between social class and coronary heart disease. Br Med J (Clin Res Ed) (1985) 1.67
Relationship between markers of activated coagulation, their correlation with inflammation, and association with coronary heart disease (NPHSII). J Thromb Haemost (2007) 1.67
Effects of anesthesia on functional activation of cerebral blood flow and metabolism. Proc Natl Acad Sci U S A (2001) 1.67
Relationship of air temperature to various chemical, haematological, and haemostatic variables. J Clin Pathol (1979) 1.65
Reduction in hospital readmission stay of elderly patients by a community based hospital discharge scheme: a randomised controlled trial. BMJ (1988) 1.65
A common DNA polymorphism of the low-density lipoprotein (LDL) receptor gene and its use in diagnosis. Lancet (1985) 1.64
Ethnic group comparisons of variables associated with ischaemic heart disease. Br Heart J (1978) 1.63
Epidemiological and clinical picture of Addison's disease. Lancet (1968) 1.63
The isolation of a clone for human alpha 1-antitrypsin and the detection of alpha 1-antitrypsin in mRNA from liver and leukocytes. Biochem Biophys Res Commun (1983) 1.62
A study of DNA polymorphisms around the human apolipoprotein AI gene in hyperlipidaemic and normal individuals. Clin Genet (1985) 1.62
Progestogens and cardiovascular reactions associated with oral contraceptives and a comparison of the safety of 50- and 30-microgram oestrogen preparations. Br Med J (1980) 1.61
Dietary and other characteristics relevant for coronary heart disease in men of Indian, West Indian and European descent in London. Atherosclerosis (1988) 1.58
Lead exposure in a firing range. Am J Public Health (1987) 1.58
Haemostatic, lipid, and blood-pressure profiles of women on oral contraceptives containing 50 microgram or 30 microgram oestrogen. Lancet (1977) 1.58
There are approximately 20 actin gene in the human genome. Nucleic Acids Res (1981) 1.58
Risk of fatal stroke in patients with treated familial hypercholesterolemia: a prospective registry study. Stroke (2003) 1.57
Factor VII in an industrial population. Br J Haematol (1974) 1.55
Variation in the PPARalpha gene is associated with altered function in vitro and plasma lipid concentrations in Type II diabetic subjects. Diabetologia (2000) 1.54
Lead absorption in indoor firing range users. Am J Public Health (1989) 1.54
Antithrombotic agents in coronary artery disease. Chest (2001) 1.53
Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19. Hum Genet (1985) 1.53
Observer variability in recording the peripheral pulses. Br Heart J (1968) 1.51
Haemostatic changes that constitute the hypercoagulable state. Lancet (1991) 1.47
Antithrombin III and procoagulant activity: sex differences and effects of the menopause. Br J Haematol (1990) 1.47
Our lives and hard times. Lancet (1975) 1.47
Factor VIII, ABO blood group and the incidence of ischaemic heart disease. Br J Haematol (1994) 1.47
Effects of sample handling on the stability of interleukin 6, tumour necrosis factor-alpha and leptin. Cytokine (2000) 1.46
Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res (2002) 1.46
Management of urinary incontinence in patients with multiple sclerosis. J R Coll Gen Pract (1981) 1.45