Potential Role of Thyroid Receptor β Agonists in the Treatment of Hyperlipidemia.

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Published in Drugs on September 02, 2017

Authors

Tomas Jakobsson1, Lise-Lotte Vedin1, Paolo Parini2,3,4

Author Affiliations

1: Division of Clinical Chemistry, C1:74, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden.
2: Division of Clinical Chemistry, C1:74, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. paolo.parini@ki.se.
3: Metabolism Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden. paolo.parini@ki.se.
4: Inflammation and Infection Theme, Karolinska University Hospital, Stockholm, Sweden. paolo.parini@ki.se.

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Identification of a thyroid hormone receptor that is pituitary-specific. Science (1989) 2.37

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Thyrotropin-releasing hormone. N Engl J Med (1982) 1.99

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Alternative splicing generates messages encoding rat c-erbA proteins that do not bind thyroid hormone. Proc Natl Acad Sci U S A (1988) 1.91

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Molecular basis of thyroid hormone-dependent brain development. Endocr Rev (1997) 1.66

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The coronary drug project. Findings leading to further modifications of its protocol with respect to dextrothyroxine. The coronary drug project research group. JAMA (1972) 1.03

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X-ray crystallographic and functional studies of thyroid hormone receptor. J Steroid Biochem Mol Biol (1998) 0.93

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Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev (2008) 0.90

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Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response. Biochim Biophys Acta (2012) 0.89

Long-term effect of dried thyroid on serum-lipoprotein and serum-cholesterol levels. Lancet (1957) 0.88

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Identification of the thyroid hormone-responsive messenger RNA spot 11 as apolipoprotein-A1 messenger RNA and effects of the hormone on the promoter. Mol Endocrinol (1992) 0.79

Effect of long-term administration of desiccated thyroid on serum lipoprotein and cholesterol levels. J Clin Endocrinol Metab (1955) 0.78

Effect of thyroid extract on serum lipoproteins and serum cholesterol. Metabolism (1954) 0.78

Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro. Mol Cell Endocrinol (2014) 0.78

Sobetirome: the past, present and questions about the future. Expert Opin Ther Targets (2015) 0.77

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Thyroid hormone receptor binds with unique properties to response elements that contain hexamer domains in an inverted palindrome arrangement. Endocrinology (1994) 0.77

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The effect of 1-thyroxine on serum lipoprotein and cholesterol concentrations. J Clin Endocrinol Metab (1959) 0.76

Thyroid hormone response to prolonged cold exposure in man. J Physiol (1974) 0.75