Published in Proc Natl Acad Sci U S A on July 08, 2005
Nuclear receptors: decoding metabolic disease. FEBS Lett (2007) 1.95
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov (2009) 1.92
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology (2012) 1.52
Targeting thyroid hormone receptor-beta agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index. Proc Natl Acad Sci U S A (2007) 1.50
American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models. Thyroid (2013) 1.41
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A (2007) 1.37
Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production. Neurobiol Dis (2007) 1.20
The liver-selective thyromimetic T-0681 influences reverse cholesterol transport and atherosclerosis development in mice. PLoS One (2010) 1.04
A TRbeta-selective agonist confers resistance to diet-induced obesity. J Endocrinol (2009) 1.01
Identical gene regulation patterns of T3 and selective thyroid hormone receptor modulator GC-1. Endocrinology (2011) 0.99
Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport. World J Gastroenterol (2010) 0.96
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways. Am J Physiol Endocrinol Metab (2013) 0.95
Thyroid function and lipid subparticle sizes in patients with short-term hypothyroidism and a population-based cohort. J Clin Endocrinol Metab (2007) 0.93
Thyroid hormone reduces cholesterol via a non-LDL receptor-mediated pathway. Endocrinology (2012) 0.92
The thyromimetic T-0681 protects from atherosclerosis. J Lipid Res (2008) 0.91
Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev (2008) 0.90
The resurgence of thyromimetics as lipid-modifying agents. Curr Opin Investig Drugs (2009) 0.88
Nuclear receptors reverse McGarry's vicious cycle to insulin resistance. Cell Metab (2012) 0.87
Thyroid hormone beta receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys. Br J Pharmacol (2009) 0.86
Reduced plasma high-density lipoprotein cholesterol in hyperthyroid mice coincides with decreased hepatic adenosine 5'-triphosphate-binding cassette transporter 1 expression. Endocrinology (2008) 0.84
Thyroid hormone analogues and derivatives: Actions in fatty liver. World J Hepatol (2014) 0.83
Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges. Curr Atheroscler Rep (2016) 0.81
Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms. BMC Struct Biol (2008) 0.81
Pleiotropic effects of thyroid hormones: learning from hypothyroidism. J Thyroid Res (2011) 0.80
New avenues for regulation of lipid metabolism by thyroid hormones and analogs. Front Physiol (2014) 0.80
Molecular functions of thyroid hormones and their clinical significance in liver-related diseases. Biomed Res Int (2013) 0.80
Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans. J Lipid Res (2014) 0.80
Selective thyroid hormone receptor modulators. Indian J Endocrinol Metab (2013) 0.80
The impact of acute hypothyroidism on lipid levels in athyreotic patients. J Res Med Sci (2012) 0.79
Thyromimetics: What does the future hold? Indian J Endocrinol Metab (2012) 0.79
Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology (2012) 0.79
Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro. Mol Cell Endocrinol (2014) 0.78
Structural modeling of high-affinity thyroid receptor-ligand complexes. Eur Biophys J (2010) 0.78
Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway. J Clin Invest (2014) 0.78
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse. Histochem Cell Biol (2007) 0.78
The thyroid receptor modulator KB3495 reduces atherosclerosis independently of total cholesterol in the circulation in ApoE deficient mice. PLoS One (2013) 0.77
Effect of thyroid hormone on the distribution and activity of Na, K-ATPase in ventricular myocardium. Arch Biochem Biophys (2008) 0.77
Thyroid hormone analogues for the treatment of metabolic disorders: new potential for unmet clinical needs? Endocr Pract (2012) 0.77
Targeting thyroid hormone receptor beta in triple-negative breast cancer. Breast Cancer Res Treat (2015) 0.76
Action of Thyroid Hormones, T3 and T2, on Hepatic Fatty Acids: Differences in Metabolic Effects and Molecular Mechanisms. Int J Mol Sci (2017) 0.75
3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats. PLoS One (2015) 0.75
Sustained zero-order delivery of GC-1 from a nanochannel membrane device alleviates metabolic syndrome. Int J Obes (Lond) (2016) 0.75
3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. Front Physiol (2016) 0.75
Thyroid hormone receptor-β1 signaling is critically involved in regulating secondary ossification via promoting transcription of the Ihh gene in the epiphysis. Am J Physiol Endocrinol Metab (2016) 0.75
Thyroid Hormone Receptor β Agonist Induces β-Catenin-Dependent Hepatocyte Proliferation in Mice: Implications in Hepatic Regeneration. Gene Expr (2016) 0.75
Potential Role of Thyroid Receptor β Agonists in the Treatment of Hyperlipidemia. Drugs (2017) 0.75
A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem (1957) 173.99
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell (1997) 17.78
The c-erb-A gene encodes a thyroid hormone receptor. Nature (1987) 10.53
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Genes Dev (2000) 9.09
The c-erb-A protein is a high-affinity receptor for thyroid hormone. Nature (1987) 7.06
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors. Mol Cell (2000) 6.48
Physiological and molecular basis of thyroid hormone action. Physiol Rev (2001) 5.69
Thyroid hormone and the cardiovascular system. N Engl J Med (2001) 5.56
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Invest (2004) 4.65
QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL FECAL BILE ACIDS. J Lipid Res (1965) 3.43
Hypothyroidism. Lancet (2004) 3.26
QUANTITATIVE ISOLATION AND GAS--LIQUID CHROMATOGRAPHIC ANALYSIS OF TOTAL DIETARY AND FECAL NEUTRAL STEROIDS. J Lipid Res (1965) 3.22
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter. Mol Cell Biol (2001) 2.68
The thyroid hormone receptor-beta-selective agonist GC-1 differentially affects plasma lipids and cardiac activity. Endocrinology (2000) 2.26
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. J Clin Invest (2001) 1.95
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans (2002) 1.82
Effects of thyroid hormone on the cardiovascular system. Recent Prog Horm Res (2004) 1.67
Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice. Endocrinology (1998) 1.60
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. J Lipid Res (2003) 1.52
Selective thyroid hormone receptor-beta activation: a strategy for reduction of weight, cholesterol, and lipoprotein (a) with reduced cardiovascular liability. Proc Natl Acad Sci U S A (2003) 1.46
Lipids, risk factors and ischaemic heart disease. Atherosclerosis (1996) 1.44
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study). J Clin Endocrinol Metab (2001) 1.37
Accumulation of foam cells in liver X receptor-deficient mice. Circulation (2002) 1.34
Importance of growth hormone for the induction of hepatic low density lipoprotein receptors. Proc Natl Acad Sci U S A (1992) 1.34
Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice. Mol Endocrinol (2002) 1.32
European guidelines on cardiovascular disease and prevention in clinical practice. Atherosclerosis (2003) 1.31
Plasma triglyceride metabolism in thyroid disease. J Clin Invest (1972) 1.28
Thyroid hormone receptor beta-deficient mice show complete loss of the normal cholesterol 7alpha-hydroxylase (CYP7A) response to thyroid hormone but display enhanced resistance to dietary cholesterol. Mol Endocrinol (2000) 1.22
Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol (2003) 1.15
Decreased selective uptake of high density lipoprotein cholesteryl esters in apolipoprotein E knock-out mice. Proc Natl Acad Sci U S A (1999) 1.13
Feedback and hormonal regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase: the concept of cholesterol buffering capacity. Proc Soc Exp Biol Med (2000) 1.13
Transcriptional regulation of rat hepatic low-density lipoprotein receptor and cholesterol 7 alpha hydroxylase by thyroid hormone. Arch Biochem Biophys (1995) 1.10
Fibrates down-regulate hepatic scavenger receptor class B type I protein expression in mice. J Biol Chem (2003) 1.10
Effects of L-triiodothyronine and the thyromimetic L-94901 on serum lipoprotein levels and hepatic low-density lipoprotein receptor, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and apo A-I gene expression. Biochem Pharmacol (1998) 1.05
Regulation of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) by thyroid hormone in transgenic mice. Endocrinology (2003) 1.04
Thyroid hormone rapidly induces hepatic LDL receptor mRNA levels in hypophysectomized rats. Arch Biochem Biophys (1994) 1.04
Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats. Biochem Biophys Res Commun (1990) 1.00
Quantitation of rat tissue thyroid hormone binding receptor isoforms by immunoprecipitation of nuclear triiodothyronine binding capacity. J Biol Chem (1992) 0.98
Changes in plasma low-density lipoprotein (LDL)- and high-density lipoprotein cholesterol in hypo- and hyperthyroid patients are related to changes in free thyroxine, not to polymorphisms in LDL receptor or cholesterol ester transfer protein genes. J Clin Endocrinol Metab (2000) 0.98
Metabolism of plasma triglycerides in hypothyroidism and hyperthyroidism in man. J Lipid Res (1981) 0.97
Gas-liquid chromatographic determination of fecal neutral sterols using a capillary column. Clin Chim Acta (1982) 0.97
Regulation of adipose tissue lipoprotein lipase gene expression by thyroid hormone in rats. J Lipid Res (1992) 0.96
Beneficial effects of a novel thyromimetic on lipoprotein metabolism. Mol Pharmacol (1997) 0.95
Hormonal regulation of cholesterol 7alpha-hydroxylase specific activity, mRNA levels, and transcriptional activity in vivo in the rat. J Lipid Res (1997) 0.94
Improved synthesis of the iodine-free thyromimetic GC-1. Bioorg Med Chem Lett (2000) 0.93
Lipolytic and ketogenic fluxes in human hyperthyroidism. J Clin Endocrinol Metab (1991) 0.92
Management of dyslipidemia. Am J Med (2002) 0.92
Orphan nuclear receptors find a home in the arterial wall. Curr Atheroscler Rep (2002) 0.91
Hormonal regulation of apolipoprotein AI. J Mol Endocrinol (1999) 0.87
Regulation by vitamin E of the scavenger receptor BI in rat liver and HepG2 cells. J Lipid Res (2000) 0.86
Prolonged stimulation of the adrenals by corticotropin suppresses hepatic low-density lipoprotein and high-density lipoprotein receptors and increases plasma cholesterol. Endocrinology (2002) 0.85
Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells. Biochem Biophys Res Commun (1994) 0.83
Interaction between growth hormone and insulin in the regulation of lipoprotein metabolism in the rat. Am J Physiol Endocrinol Metab (2002) 0.82
Growth hormone reduces plasma cholesterol in LDL receptor-deficient mice. FASEB J (2001) 0.82
Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. Metabolism (2004) 0.80
Plasma levels of lipoproteins and apolipoproteins in congenital hypothyroidism: effects of L-thyroxine substitution therapy. Metabolism (1995) 0.80
Is triiodothyronine capable of ameliorating pyrethroid-induced thyroid dysfunction and lipid peroxidation? J Appl Toxicol (1998) 0.79
Importance of estrogen receptors in hepatic LDL receptor regulation. Arterioscler Thromb Vasc Biol (1997) 0.79
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab (2013) 4.88
Interleukin-6-deficient mice develop mature-onset obesity. Nat Med (2002) 4.47
The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man. Cell Metab (2008) 3.34
Use of the thyroid hormone analogue eprotirome in statin-treated dyslipidemia. N Engl J Med (2010) 3.17
Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab (2013) 3.00
PPARalpha is a key regulator of hepatic FGF21. Biochem Biophys Res Commun (2007) 2.77
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res (2008) 2.76
Prevalent abnormal prion protein in human appendixes after bovine spongiform encephalopathy epizootic: large scale survey. BMJ (2013) 2.74
Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C. J Neurosci (2003) 2.73
Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res (2003) 2.44
A G-protein-coupled estrogen receptor is involved in hypothalamic control of energy homeostasis. J Neurosci (2006) 2.40
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Identification of a structural determinant necessary for the localization and function of estrogen receptor alpha at the plasma membrane. Mol Cell Biol (2003) 2.19
Effects of n-6 PUFAs compared with SFAs on liver fat, lipoproteins, and inflammation in abdominal obesity: a randomized controlled trial. Am J Clin Nutr (2012) 2.10
Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease. Hepatology (2007) 2.05
Angiogenesis inhibitor, TNP-470, prevents diet-induced and genetic obesity in mice. Circ Res (2004) 2.04
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet (2003) 1.99
Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J Clin Invest (2003) 1.98
A surface on the androgen receptor that allosterically regulates coactivator binding. Proc Natl Acad Sci U S A (2007) 1.97
Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med (2003) 1.95
Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression. J Biol Chem (2002) 1.95
T cell-mediated inflammation in adipose tissue does not cause insulin resistance in hyperlipidemic mice. Circ Res (2009) 1.93
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov (2009) 1.92
Thyronamines inhibit plasma membrane and vesicular monoamine transport. ACS Chem Biol (2007) 1.91
CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med (2004) 1.80
Rapid nongenomic actions of thyroid hormone. Proc Natl Acad Sci U S A (2006) 1.79
ACAT2 is localized to hepatocytes and is the major cholesterol-esterifying enzyme in human liver. Circulation (2004) 1.76
Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect (2010) 1.75
Prevention of spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice by intestinal-specific farnesoid X receptor reactivation. Hepatology (2014) 1.68
4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer. J Med Chem (2007) 1.67
Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res (2005) 1.67
Circulating fibroblast growth factors as metabolic regulators--a critical appraisal. Cell Metab (2012) 1.67
The molecular mechanisms of coactivator utilization in ligand-dependent transactivation by the androgen receptor. J Biol Chem (2004) 1.66
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation (2008) 1.64
Estimating changes in mean body temperature for humans during exercise using core and skin temperatures is inaccurate even with a correction factor. J Appl Physiol (1985) (2007) 1.62
Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest (2013) 1.61
Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administration. Clin Chem (2012) 1.57
Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis. Gastroenterology (2005) 1.53
Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J Med Chem (2006) 1.52
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response. Genes Dev (2010) 1.52
Thyroid hormone receptor agonists reduce serum cholesterol independent of the LDL receptor. Endocrinology (2012) 1.52
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. J Lipid Res (2003) 1.52
Amphioxus postembryonic development reveals the homology of chordate metamorphosis. Curr Biol (2008) 1.51
In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23 on rat liver, heart, and brain. Endocrinology (2011) 1.50
The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Cell Metab (2014) 1.47
Effects of cholesteryl ester transfer protein inhibition on high-density lipoprotein subspecies, apolipoprotein A-I metabolism, and fecal sterol excretion. Arterioscler Thromb Vasc Biol (2005) 1.43
Decreased fat storage by Lactobacillus paracasei is associated with increased levels of angiopoietin-like 4 protein (ANGPTL4). PLoS One (2010) 1.43
Effects of the thyroid hormone receptor agonist GC-1 on metabolic rate and cholesterol in rats and primates: selective actions relative to 3,5,3'-triiodo-L-thyronine. Endocrinology (2003) 1.42
Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res (2009) 1.39
[The apoB/apoA-I ratio is better myocardial infarction marker than lipids]. Lakartidningen (2006) 1.39
Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations. Proc Natl Acad Sci U S A (2011) 1.39
The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proc Natl Acad Sci U S A (2007) 1.37
p300 Modulates the BRCA1 inhibition of estrogen receptor activity. Cancer Res (2002) 1.36
Accumulation of foam cells in liver X receptor-deficient mice. Circulation (2002) 1.34
Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity. Genes Dev (2006) 1.34
Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function. FASEB J (2007) 1.34
Requirement for thyroid hormone receptor beta in T3 regulation of cholesterol metabolism in mice. Mol Endocrinol (2002) 1.32
Discovery of small molecule inhibitors of the interaction of the thyroid hormone receptor with transcriptional coregulators. J Biol Chem (2005) 1.32
Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis. Arterioscler Thromb Vasc Biol (2010) 1.31
Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem (2002) 1.28
ACAT2 is a target for treatment of coronary heart disease associated with hypercholesterolemia. Arterioscler Thromb Vasc Biol (2005) 1.28
Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol Metab (2004) 1.28
Rosiglitazone attenuates age- and diet-associated nonalcoholic steatohepatitis in male low-density lipoprotein receptor knockout mice. Hepatology (2010) 1.27
Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7alpha-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice. J Biol Chem (2003) 1.26
Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia. Proc Natl Acad Sci U S A (2008) 1.26
Monitoring for bovine spongiform encephalopathy in sheep in Great Britain, 1998-2004. J Gen Virol (2006) 1.25
The oxysterol receptor LXR inhibits proliferation of human breast cancer cells. Carcinogenesis (2009) 1.24
Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke (2007) 1.23
Tissue distribution and cardiac metabolism of 3-iodothyronamine. Endocrinology (2010) 1.22
Structural rearrangements in the thyroid hormone receptor hinge domain and their putative role in the receptor function. J Mol Biol (2006) 1.22
Intestinal specific LXR activation stimulates reverse cholesterol transport and protects from atherosclerosis. Cell Metab (2010) 1.20
Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis. Proc Natl Acad Sci U S A (2007) 1.20
Anti-obesity, anti-diabetic, and lipid lowering effects of the thyroid receptor beta subtype selective agonist KB-141. J Steroid Biochem Mol Biol (2008) 1.19
Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE). Am J Gastroenterol (2010) 1.17
Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor. Proc Natl Acad Sci U S A (2003) 1.17
Thyroxine-thyroid hormone receptor interactions. J Biol Chem (2004) 1.17
Effectiveness and cost-effectiveness of a stepped care intervention for alcohol use disorders in primary care: pilot study. Br J Psychiatry (2009) 1.17
Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone. J Med Chem (2009) 1.17
Toward deciphering the code to aminergic G protein-coupled receptor drug design. Chem Biol (2008) 1.16
Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res (2007) 1.11
Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-L-thyronine and inhibit homodimer formation. J Biol Chem (2005) 1.10
Structural insight into the mode of action of a direct inhibitor of coregulator binding to the thyroid hormone receptor. Mol Endocrinol (2007) 1.10
Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity. FASEB J (2010) 1.10
Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes. Hepatology (2010) 1.09