In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles.

PubWeight™: 0.75^‹?›

🔗 View Article (PMID 28921841)

Published in Aging Cell on September 17, 2017

Authors

Erez Eitan¹, Valeria Tosti², Caitlin N Suire¹, Edda Cava², Sean Berkowitz¹, Beatrice Bertozzi², Sophia M Raefsky¹, Nicola Veronese²^,3, Ryan Spangler¹, Francesco Spelta²^,4, Maja Mustapic¹, Dimitrios Kapogiannis¹, Mark P Mattson¹^,5, Luigi Fontana²^,6^,7

Author Affiliations

1: Laboratory of Neurosciences, National Institute on Aging, NIH, 251 Bayview Boulevard, Baltimore, MD, 21224, USA.
2: Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St. Louis, MO, 63110, USA.
3: Department of Medicine (DIMED), Geriatrics Division, University of Padova, 35128, Padova, Italy.
4: Department of Medicine, University of Verona, 37129, Verona, Italy.
5: Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD, 21205, USA.
6: Department of Clinical and Experimental Sciences, Brescia University, 25121, Brescia, Italy.
7: CEINGE Biotecnologie Avanzate, 80122, Napoli, Italy.

Associated clinical trials:

Does Protein Restriction Inhibit Prostrate Cancer Growth | NCT01692587

Articles cited by this ↗

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest (2012) 3.65

Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials. JAMA Oncol (2015) 3.64

Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles (2015) 3.02

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma. Free Radic Biol Med (2006) 2.32

Sixteen years and counting: an update on leptin in energy balance. J Clin Invest (2011) 2.21

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05

Calorie restriction and cancer prevention: metabolic and molecular mechanisms. Trends Pharmacol Sci (2010) 1.82

The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women. Br J Nutr (2013) 1.56

Insulin and aging. Cell Cycle (2008) 1.55

Interventions to Slow Aging in Humans: Are We Ready? Aging Cell (2015) 1.46

Current treatment strategies for inhibiting mTOR in cancer. Trends Pharmacol Sci (2014) 1.26

Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB J (2014) 1.20

Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism (2014) 1.18

Dietary protein restriction inhibits tumor growth in human xenograft models. Oncotarget (2013) 1.02

Effects of aging on insulin secretion. Diabetes (1989) 0.87

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health. Cell Rep (2016) 0.78

Caloric restriction - A promising anti-cancer approach: From molecular mechanisms to clinical trials. Biochim Biophys Acta (2016) 0.78

Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance. J Chem Neuroanat (2014) 0.77

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes. Front Neurosci (2017) 0.76

Dietary protein, aging and nutritional geometry. Ageing Res Rev (2017) 0.76

Exosomal biomarkers of brain insulin resistance associated with regional atrophy in Alzheimer's disease. Hum Brain Mapp (2017) 0.75