Published in Oxid Med Cell Longev on August 08, 2017
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Autophagy: process and function. Genes Dev (2007) 15.21
The classical complement cascade mediates CNS synapse elimination. Cell (2007) 9.06
The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol (2000) 8.10
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
The ubiquitin system. Trends Biochem Sci (1997) 4.67
Molecular inflammation: underpinnings of aging and age-related diseases. Ageing Res Rev (2008) 4.14
A potential role for immune complex pathogenesis in drusen formation. Exp Eye Res (2000) 2.58
Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex. Mol Aspects Med (2012) 2.37
Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta (2008) 1.73
Age-related retinopathy in NRF2-deficient mice. PLoS One (2011) 1.71
The Molecular Signatures Database (MSigDB) hallmark gene set collection. Cell Syst (2015) 1.70
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study. J Neuroinflammation (2012) 1.57
Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J Biol Chem (2009) 1.45
For better or for worse: complexins regulate SNARE function and vesicle fusion. Traffic (2008) 1.45
Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. Exp Eye Res (2006) 1.36
Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration. Autophagy (2013) 1.34
The proteasome and its role in the degradation of oxidized proteins. IUBMB Life (2008) 1.32
Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci (2005) 1.25
Autophagy activation clears ELAVL1/HuR-mediated accumulation of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS One (2013) 1.20
Oxidative stress, hypoxia, and autophagy in the neovascular processes of age-related macular degeneration. Biomed Res Int (2014) 1.13
Autophagy, exosomes and drusen formation in age-related macular degeneration. Autophagy (2009) 1.12
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy (2014) 1.11
Aberrant function and structure of retinal ribbon synapses in the absence of complexin 3 and complexin 4. J Cell Sci (2009) 1.05
Deficiencies of vitamins E and A in the rat. Retinal damage and lipofuscin accumulation. Invest Ophthalmol Vis Sci (1980) 1.04
Low glutathione reductase and peroxidase activity in age-related macular degeneration. Br J Ophthalmol (1994) 0.96
Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci (2015) 0.95
Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol (2015) 0.94
A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci. PLoS One (2012) 0.92
Long-term neuroprotective effects of NT-4-engineered mesenchymal stem cells injected intravitreally in a mouse model of acute retinal injury. Invest Ophthalmol Vis Sci (2013) 0.89
Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea. Exp Gerontol (2004) 0.87
The loss of the PDE6 deactivating enzyme, RGS9, results in precocious light adaptation at low light levels. J Vis (2008) 0.85
Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiol Aging (2015) 0.84
Biomarkers of oxidative stress in patients with wet age related macular degeneration. J Nutr Health Aging (2013) 0.82
The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells. Autophagy (2015) 0.81
Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration. Cell Death Dis (2017) 0.80
Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration. Redox Biol (2015) 0.80
Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats. Int J Oncol (2006) 0.79
Protease nexin-1 regulates retinal vascular development. Cell Mol Life Sci (2015) 0.78
Autophagy regulates death of retinal pigment epithelium cells in age-related macular degeneration. Cell Biol Toxicol (2016) 0.78
Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms. Biol Open (2011) 0.78
Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and reactive aldehyde toxicity in V79-4 cells. Toxicol In Vitro (2014) 0.78
Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD). Adv Exp Med Biol (2016) 0.78
Sex-related gene expression profiles in the adrenal cortex in the mature rat: microarray analysis with emphasis on genes involved in steroidogenesis. Int J Mol Med (2015) 0.77