Published in Sci Rep on September 21, 2017
Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87
UniProt: a hub for protein information. Nucleic Acids Res (2014) 16.72
Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer (2006) 11.48
STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res (2014) 10.79
Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell (1993) 10.15
IUPred: web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics (2005) 9.02
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins. Nat Biotechnol (2004) 7.02
Cell-free formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell (2012) 6.83
Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron (2004) 6.71
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20
Stress granule assembly is mediated by prion-like aggregation of TIA-1. Mol Biol Cell (2004) 6.04
FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded. Bioinformatics (2005) 5.44
A census of glutamine/asparagine-rich regions: implications for their conserved function and the prediction of novel prions. Proc Natl Acad Sci U S A (2000) 4.19
RONN: the bio-basis function neural network technique applied to the detection of natively disordered regions in proteins. Bioinformatics (2005) 4.18
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature (2013) 4.03
PONDR-FIT: a meta-predictor of intrinsically disordered amino acids. Biochim Biophys Acta (2010) 3.62
Quantitative evaluation of congo red binding to amyloid-like proteins with a beta-pleated sheet conformation. J Histochem Cytochem (1989) 3.26
Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol Endocrinol (2003) 3.04
AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides. BMC Bioinformatics (2007) 3.02
The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res (2012) 3.00
Prions: protein aggregation and infectious diseases. Physiol Rev (2009) 2.73
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation. Cold Spring Harb Perspect Biol (2012) 2.19
Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization. Cell (2015) 2.17
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation. Cell (2015) 2.15
Characterization of an RNA granule from developing brain. Mol Cell Proteomics (2005) 2.07
Prions in yeast. Genetics (2012) 2.04
How evolutionary pressure against protein aggregation shaped chaperone specificity. J Mol Biol (2005) 1.91
Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case. Proc Natl Acad Sci U S A (2004) 1.83
The Zyggregator method for predicting protein aggregation propensities. Chem Soc Rev (2008) 1.81
Phosphorylation-regulated binding of RNA polymerase II to fibrous polymers of low-complexity domains. Cell (2013) 1.81
Prevention of amyloid-like aggregation as a driving force of protein evolution. EMBO Rep (2007) 1.78
Mouse Eya genes are expressed during limb tendon development and encode a transcriptional activation function. Proc Natl Acad Sci U S A (1997) 1.61
A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes. Genome Biol (2003) 1.61
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49
Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Hum Mol Genet (2001) 1.46
Hyper-expansion of asparagines correlates with an abundance of proteins with prion-like domains in Plasmodium falciparum. Mol Biochem Parasitol (2004) 1.39
De novo design of synthetic prion domains. Proc Natl Acad Sci U S A (2012) 1.30
The DEAD box proteins DDX5 (p68) and DDX17 (p72): multi-tasking transcriptional regulators. Biochim Biophys Acta (2013) 1.23
Multi-talented DEAD-box proteins and potential tumor promoters: p68 RNA helicase (DDX5) and its paralog, p72 RNA helicase (DDX17). Am J Transl Res (2010) 1.15
EYA1 phosphatase function is essential to drive breast cancer cell proliferation through cyclin D1. Cancer Res (2013) 1.10
Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits. Cell (2016) 1.04
Redefining the modular organization of the core Mediator complex. Cell Res (2014) 1.02
DDX5 regulates DNA replication and is required for cell proliferation in a subset of breast cancer cells. Cancer Discov (2012) 1.02
Eya1 interacts with Six2 and Myc to regulate expansion of the nephron progenitor pool during nephrogenesis. Dev Cell (2014) 0.95
PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition. Bioinformatics (2014) 0.95
Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC Genomics (2013) 0.95
Hacking the code of amyloid formation: the amyloid stretch hypothesis. Prion (2007) 0.93
Dictyostelium discoideum has a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation. Proc Natl Acad Sci U S A (2015) 0.93
Ile-phe dipeptide self-assembly: clues to amyloid formation. Biophys J (2006) 0.93
What makes a protein sequence a prion? PLoS Comput Biol (2015) 0.92
Functional role of Tia1/Pub1 and Sup35 prion domains: directing protein synthesis machinery to the tubulin cytoskeleton. Mol Cell (2014) 0.92
Yeast prions act as genes composed of self-propagating protein amyloids. Adv Protein Chem (2001) 0.92
Mutation in PHC1 implicates chromatin remodeling in primary microcephaly pathogenesis. Hum Mol Genet (2013) 0.92
Luminidependens (LD) is an Arabidopsis protein with prion behavior. Proc Natl Acad Sci U S A (2016) 0.90
PrionScan: an online database of predicted prion domains in complete proteomes. BMC Genomics (2014) 0.90
A bacterial global regulator forms a prion. Science (2017) 0.89
Human prion diseases: from Kuru to variant Creutzfeldt-Jakob disease. Subcell Biochem (2012) 0.85
Prions: What Are They Good For? Annu Rev Cell Dev Biol (2015) 0.83
Thioflavin-T excimer formation upon interaction with amyloid fibers. Chem Commun (Camb) (2013) 0.83
Native structure protects SUMO proteins from aggregation into amyloid fibrils. Biomacromolecules (2012) 0.83
PrionW: a server to identify proteins containing glutamine/asparagine rich prion-like domains and their amyloid cores. Nucleic Acids Res (2015) 0.83
Characterization of Amyloid Cores in Prion Domains. Sci Rep (2016) 0.81
RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45. J Biol Chem (2014) 0.81
Amyloids or prions? That is the question. Prion (2015) 0.80
Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast. Nucleic Acids Res (2015) 0.80
Ilf3 and NF90 functions in RNA biology. Wiley Interdiscip Rev RNA (2014) 0.79
The evolutionary scope and neurological disease linkage of yeast-prion-like proteins in humans. Biol Direct (2016) 0.78
The Rho Termination Factor of Clostridium botulinum Contains a Prion-Like Domain with a Highly Amyloidogenic Core. Front Microbiol (2016) 0.78
MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search. Nucleic Acids Res (2016) 0.77
SRC-2 orchestrates polygenic inputs for fine-tuning glucose homeostasis. Proc Natl Acad Sci U S A (2015) 0.77
NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer. Genes Chromosomes Cancer (2016) 0.76
Prion-like proteins and their computational identification in proteomes. Expert Rev Proteomics (2017) 0.75
Amyloid cores in prion domains: Key regulators for prion conformational conversion. Prion (2017) 0.75
SRC-2-mediated coactivation of anti-tumorigenic target genes suppresses MYC-induced liver cancer. PLoS Genet (2017) 0.75