Published in Chem Sci on December 10, 2015
Molecular cloning of the whole biosynthetic pathway of a Streptomyces antibiotic and its expression in a heterologous host. Nature (1984) 3.61
Automated assignment of ambiguous nuclear overhauser effects with ARIA. Methods Enzymol (2001) 2.55
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Biosynthesis of anthraquinones by interspecies cloning of actinorhodin biosynthesis genes in streptomycetes: clarification of actinorhodin gene functions. J Bacteriol (1990) 1.55
Structural studies of fatty acyl-(acyl carrier protein) thioesters reveal a hydrophobic binding cavity that can expand to fit longer substrates. J Mol Biol (2006) 1.48
X-ray crystallographic studies on butyryl-ACP reveal flexibility of the structure around a putative acyl chain binding site. Structure (2002) 1.41
Actinorhodin is a chromosomally-determined antibiotic in Streptomyces coelicolar A3(2). J Gen Microbiol (1976) 1.40
Polyketide chain length control by chain length factor. J Am Chem Soc (2003) 1.35
Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor. Chem Biol (1994) 1.19
Probing the Interactions of early polyketide intermediates with the Actinorhodin ACP from S. coelicolor A3(2). J Mol Biol (2009) 1.12
A mammalian type I fatty acid synthase acyl carrier protein domain does not sequester acyl chains. J Biol Chem (2007) 1.10
Recognition of intermediate functionality by acyl carrier protein over a complete cycle of fatty acid biosynthesis. Chem Biol (2010) 1.07
Binding and "pKa" modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. ACS Chem Biol (2011) 1.00
MCAT is not required for in vitro polyketide synthesis in a minimal actinorhodin polyketide synthase from Streptomyces coelicolor. Chem Biol (1998) 0.97
The chain-flipping mechanism of ACP (acyl carrier protein)-dependent enzymes appears universal. Biochem J (2014) 0.92
The length of the bound fatty acid influences the dynamics of the acyl carrier protein and the stability of the thioester bond. Biochemistry (2010) 0.90
Acylation of Streptomyces type II polyketide synthase acyl carrier proteins. FEBS Lett (1998) 0.88
Probing the phosphopantetheine arm conformations of acyl carrier proteins using vibrational spectroscopy. J Am Chem Soc (2014) 0.84
The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chem Biol (2013) 0.83
Modeling linear and cyclic PKS intermediates through atom replacement. J Am Chem Soc (2014) 0.83
Proposed arrangement of proteins forming a bacterial type II polyketide synthase. Chem Biol (2008) 0.79
Enantioselective carbohydrate recognition by synthetic lectins in water. Chem Sci (2017) 0.75
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics. Chem Sci (2017) 0.75