Published in J Am Chem Soc on October 22, 2003
Deconstruction of iterative multidomain polyketide synthase function. Science (2008) 3.02
Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A (2008) 1.78
Biosynthesis of aromatic polyketides in bacteria. Acc Chem Res (2009) 1.34
Widespread occurrence of secondary lipid biosynthesis potential in microbial lineages. PLoS One (2011) 1.10
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol (2006) 1.08
In vivo and in vitro analysis of the hedamycin polyketide synthase. Chem Biol (2009) 1.08
Cyclization of aromatic polyketides from bacteria and fungi. Nat Prod Rep (2010) 1.05
Biosynthetic mechanism for sunscreens of the biocontrol agent Lysobacter enzymogenes. PLoS One (2013) 0.95
Structural enzymology of polyketide synthases. Methods Enzymol (2009) 0.93
PKMiner: a database for exploring type II polyketide synthases. BMC Microbiol (2012) 0.90
Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl Microbiol Biotechnol (2010) 0.88
Oxytetracycline biosynthesis. J Biol Chem (2010) 0.86
Structural analysis of protein-protein interactions in type I polyketide synthases. Crit Rev Biochem Mol Biol (2012) 0.85
Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry (2011) 0.84
Evolution of chemical diversity by coordinated gene swaps in type II polyketide gene clusters. Proc Natl Acad Sci U S A (2015) 0.84
The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chem Biol (2013) 0.83
Protein engineering towards natural product synthesis and diversification. J Ind Microbiol Biotechnol (2011) 0.83
Cracking the polyketide code. PLoS Biol (2004) 0.82
In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic. Synlett (2015) 0.81
Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo. Fungal Genet Biol (2010) 0.81
Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chem Biol (2011) 0.81
Functional replacement of the ketosynthase domain of FUM1 for the biosynthesis of fumonisins, a group of fungal reduced polyketides. J Ind Microbiol Biotechnol (2006) 0.76
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides. Beilstein J Org Chem (2016) 0.75
Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein. Chem Sci (2015) 0.75
Structural basis for gluten intolerance in celiac sprue. Science (2002) 8.16
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2006) 2.63
Transglutaminase 2 undergoes a large conformational change upon activation. PLoS Biol (2007) 2.53
Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci U S A (2004) 2.33
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science (2013) 2.31
The type I fatty acid and polyketide synthases: a tale of two megasynthases. Nat Prod Rep (2007) 2.28
Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chem Biol (2007) 2.02
Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chem Biol (2005) 2.00
Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metab Eng (2008) 1.97
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature (2009) 1.94
Intestinal digestive resistance of immunodominant gliadin peptides. Am J Physiol Gastrointest Liver Physiol (2002) 1.87
An antibiotic factory caught in action. Nat Struct Mol Biol (2004) 1.81
Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chem Biol (2003) 1.81
Evolution of polyketide synthases in bacteria. Proc Natl Acad Sci U S A (2008) 1.78
Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Sci (2007) 1.68
Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (2003) 1.67
Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. PLoS One (2008) 1.67
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry (2002) 1.66
Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. J Proteome Res (2005) 1.63
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2006) 1.63
Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. Biochem J (2004) 1.63
Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacol Ther (2007) 1.60
Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology (2007) 1.58
Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2007) 1.56
Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metab Eng (2010) 1.55
High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry (2002) 1.49
Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem Biol (2013) 1.47
Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry (2004) 1.47
Structure-based dissociation of a type I polyketide synthase module. Chem Biol (2007) 1.46
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry (2002) 1.45
In living color: bacterial pigments as an untapped resource in the classroom and beyond. PLoS Biol (2010) 1.44
Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2006) 1.42
The biochemical basis for stereochemical control in polyketide biosynthesis. J Am Chem Soc (2009) 1.39
Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clin Gastroenterol Hepatol (2005) 1.38
Redox regulation of transglutaminase 2 activity. J Biol Chem (2010) 1.38
Dietary gluten triggers concomitant activation of CD4+ and CD8+ αβ T cells and γδ T cells in celiac disease. Proc Natl Acad Sci U S A (2013) 1.36
Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Appl Environ Microbiol (2002) 1.35
Biosynthesis of aromatic polyketides in bacteria. Acc Chem Res (2009) 1.34
Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proc Natl Acad Sci U S A (2008) 1.34
Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry (2003) 1.34
Future therapeutic options for celiac disease. Nat Clin Pract Gastroenterol Hepatol (2005) 1.33
Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. J Am Chem Soc (2005) 1.33
Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. PLoS One (2008) 1.32
Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. J Bacteriol (2006) 1.29
Rational design of combination enzyme therapy for celiac sprue. Chem Biol (2006) 1.28
Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci U S A (2005) 1.27
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proc Natl Acad Sci U S A (2010) 1.27
Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry (2003) 1.27
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.25
Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. J Am Chem Soc (2003) 1.24
Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J Biol Chem (2002) 1.24
In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proc Natl Acad Sci U S A (2011) 1.23
Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. J Immunol (2004) 1.23
Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. J Am Chem Soc (2008) 1.22
Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (2002) 1.21
Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Mol Cancer Ther (2005) 1.20
Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo. J Pharmacol Exp Ther (2004) 1.19
Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proc Natl Acad Sci U S A (2012) 1.19
Combinatorial biosynthesis of polyketides--a perspective. Curr Opin Chem Biol (2012) 1.19
Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry (2011) 1.18
Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry (2004) 1.18
Crystal structure of the beta-subunit of acyl-CoA carboxylase: structure-based engineering of substrate specificity. Biochemistry (2004) 1.17
Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chem Biol (2006) 1.17
A non-human primate model for gluten sensitivity. PLoS One (2008) 1.17
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. J Biol Chem (2003) 1.17
Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses. Clin Gastroenterol Hepatol (2005) 1.16
Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization. J Pharmacol Exp Ther (2004) 1.15
Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry (2005) 1.14
Fatty acid biosynthesis in actinomycetes. FEMS Microbiol Rev (2011) 1.13
Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnol Bioeng (2005) 1.13
ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology (2009) 1.13
Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry (2005) 1.11
A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One (2009) 1.10
Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol (2003) 1.10
Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase. J Am Chem Soc (2010) 1.09
Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. PLoS One (2008) 1.09
Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Appl Environ Microbiol (2006) 1.08
In vivo and in vitro analysis of the hedamycin polyketide synthase. Chem Biol (2009) 1.08
Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat. J Pharmacol Exp Ther (2006) 1.08
Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. Biochemistry (2010) 1.07
Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology (2007) 1.07
Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. J Med Chem (2006) 1.07
Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. Chem Biol (2002) 1.06
Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. PLoS Biol (2004) 1.06
Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. J Am Chem Soc (2003) 1.06
In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. J Am Chem Soc (2013) 1.06
Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. J Am Chem Soc (2012) 1.06
Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry (2002) 1.05
Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry (2004) 1.04
Activation of extracellular transglutaminase 2 by thioredoxin. J Biol Chem (2011) 1.03
The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry (2004) 1.03
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Eng Des Sel (2008) 1.03
Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. J Mol Biol (2003) 1.03
Oral enzyme therapy for celiac sprue. Methods Enzymol (2012) 1.03
Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry (2002) 1.02
Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorg Med Chem Lett (2008) 1.02
Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angew Chem Int Ed Engl (2013) 1.02
Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. J Am Chem Soc (2003) 1.01